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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Target of myb1

TOM1, SSR2, target of Myb 1
This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: ACID, Ubiquitin, CAN, HAD, somatostatin
Papers on TOM1
The Phytosiderophore Efflux Transporter TOM2 Is Involved in Metal Transport in Rice.
Nishizawa et al., Tokyo, Japan. In J Biol Chem, Dec 2015
In this study, we analyzed TOM2 and TOM3, rice homologs of transporter of mugineic acid family phytosiderophores 1 (TOM1), a crucial efflux transporter directly involved in phytosiderophore secretion into the soil.
Transcriptomic analyses of maize ys1 and ys3 mutants reveal maize iron homeostasis.
Nishizawa et al., Yokohama, Japan. In Genom Data, Sep 2015
To acquire iron (Fe), graminaceous plants secrete mugineic acid family phytosiderophores (MAs) (Takagi, 1976 [1]) through the MAs efflux transporter TOM1 (Nozoye et al., 2011 [2]) and take up Fe in the form of Fe(III)-MAs complexes through the Fe(III)-MAs transporter YS1 (Curie et al., 2001 [3]).
Comparative proteomic analyses of two reovirus T3D subtypes and comparison to T1L identifies multiple novel proteins in key cellular pathogenic pathways.
Coombs et al., Winnipeg, Canada. In Proteomics, Jun 2015
We also identified several proteins not previously identified in any virus infection; branched chain amino-acid transaminase 2 (BCAT), paternally expressed 10 (PEG10), target of myb1 (TOM1), histone cluster 2 H4b (HIST2H4B) and tubulin beta 4B (TUBB4B).
Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism.
Tu et al., Taipei, Taiwan. In Autophagy, May 2015
UbBD mutants exhibited a weakened interaction with MYO6 (myosin VI) and TOM1 (target of myb1 homolog [chicken]), important for autophagosome maturation, in cells or sorted 109QmHtt IBs.
TOM1 is a PI5P effector involved in the regulation of endosomal maturation.
Tronchère et al., Toulouse, France. In J Cell Sci, Mar 2015
Here, we show that the adaptor protein TOM1 is a new direct binding partner of PI5P.
Iron deficiency responses in rice roots.
Nishizawa et al., Kawaguchi, Japan. In Rice (n Y), 2014
Key components in this response include enzymes involved in the biosynthesis of deoxymugineic acid (OsNAS1, OsNAS2, OsNAAT1, and OsDMAS1), the deoxymugineic acid efflux transporter (TOM1), the Fe(III)-deoxymugineic acid transporter (OsYSL15), and Fe(2+) transporters (OsIRT1, OsIRT2, and OsNRAMP1).
Molecular Cloning, Carbohydrate Specificity and the Crystal Structure of Two Sclerotium rolfsii Lectin Variants.
Leonidas et al., Lárisa, Greece. In Molecules, 2014
SSR1 and SSR2 are two different recombinant variants of SRL, both of which recognize TF antigen but only SSR1 binds to Tn antigen (GalNAcα-Ser/Thr).
Sterol side chain reductase 2 is a key enzyme in the biosynthesis of cholesterol, the common precursor of toxic steroidal glycoalkaloids in potato.
Umemoto et al., Chiba, Japan. In Plant Cell, 2014
Here, we identify sterol side chain reductase 2 (SSR2) from potato as a key enzyme in the biosynthesis of cholesterol and related SGAs.
Hepatic somatostatin receptor 2 expression during premalignant stages of hepatocellular carcinoma.
Thabet et al., Egypt. In Tumour Biol, 2014
Both liver tissue SSR2 protein and mRNA, liver AFP, and caspase-3 mRNA expression, concomitant to tissue malondialdehyde (MDA), were significantly elevated with depressed reduced glutathione (GSH).
Arabidopsis TOL proteins act as gatekeepers for vacuolar sorting of PIN2 plasma membrane protein.
Luschnig et al., Vienna, Austria. In Curr Biol, 2014
Here, we describe members of an Arabidopsis TOL (TOM1-LIKE) family as ubiquitin binding proteins that act redundantly in control of plant morphogenesis.
Expression of Arabidopsis TOL genes.
Korbei et al., Vienna, Austria. In Plant Signal Behav, 2013
(2) Recently, we have identified a family of proteins in higher plants, which function in vacuolar targeting and subsequent degradation of ubiquitinated plasma membrane proteins (3,4) termed TOM1-like (TOL) proteins.
Expression of Arabidopsis TOL genes.
Korbei et al., Vienna, Austria. In Plant Signal Behav, 2013
(2) Recently, we have identified a family of proteins in higher plants, which function in vacuolar targeting and subsequent degradation of ubiquitinated plasma membrane proteins (3) (,) (4) termed TOM1-like (TOL) proteins.
miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression.
Greene et al., Ireland. In J Immunol, 2010
TOM1 is a microRNA-126 target that may have an important role in regulating innate immune responses in the cystic fibrosis lung.
Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis.
Gunjan et al., Tallahassee, United States. In Nat Cell Biol, 2009
Data demonstrated that excess histones associate with Rad53, and also identified Ubc4 and Ubc5, as well as Tom1 as enzymes involved in the ubiquitylation of excess histones.
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Barber et al., Miami, United States. In Nature, 2008
Yeast two-hybrid and co-immunoprecipitation studies indicated that STING interacts with RIG-I and with SSR2 (also known as TRAPbeta), which is a member of the translocon-associated protein (TRAP) complex required for protein translocation across the endoplasmic reticulum membrane following translation.
Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation.
Walker et al., Ottawa, Canada. In J Neurosci Res, 2008
SOX2 enhancers SRR1 and SRR2 are each differentially methylated and acetylated, on a temporal basis, contributing to the generation of neuron- and astrocyte-specific epigenomes from a common progenitor cell.
Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1.
NIMH Genetics Initiative Bipolar Disorder Consortium et al., Baltimore, United States. In Am J Med Genet B Neuropsychiatr Genet, 2008
A 3-marker haplotype of SNPs within TOM1 was associated with psychotic bipolar affective disorder linkage
Recruitment of clathrin onto endosomes by the Tom1-Tollip complex.
Nakayama et al., Kyoto, Japan. In Biochem Biophys Res Commun, 2006
These results indicate that, in conjunction with Tollip, Tom1 family proteins play an important role in recruiting clathrin onto endosomes and suggest that they modulate endosomal functions.
Ubiquitin-binding proteins: similar, but different.
Hartmann-Petersen et al., Copenhagen, Denmark. In Essays Biochem, 2004
The smaller groups of UIM (ubiquitin-interacting motif), GAT [GGA (Golgi-associated gamma-adaptin homologous) and Tom1 (target of Myb 1)], CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation), UEV [ubiquitin E2 (ubiquitin-conjugating enzyme) variant] and NZF (nuclear protein localization gene 4 zinc finger) domain-containing proteins appear to have more specialized functions.
Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.
Wakatsuki et al., Tsukuba, Japan. In Nature, 2002
The VHS domain forms a super helix with eight alpha-helices, similar to the VHS domains of TOM1 and Hrs.
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