[Negative regulation of Toll-like receptor signalling].
Lublin, Poland. In Postepy Hig Med Dosw (online), 2012
They include soluble receptors (sTLR), transmembrane proteins (ST2, SIGIRR, RP105, TRAIL-R) and intracellular inhibitors (SOCS-1, SOCS-3, sMyD88, TOLLIP, IRAK-M, SARM, A20, β-arrestin, CYLD, SHP).
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
Biel, Switzerland. In Nat Cell Biol, 2000
Binding of IL-1 to its receptor results in rapid assembly of a membrane-proximal signalling complex that consists of two different receptor chains (IL-1Rs), IL-1RI and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein, which we have named Tollip.