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TOX high mobility group box family member 3

TNRC9, TOX3, trinucleotide repeat containing 9
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009] (from NCBI)
Papers on TNRC9
Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers.
GeneRIF
Belinsky et al., Albuquerque, United States. In Plos One, 2011
Compared with TOX4, expression of TOX1, TOX2 and TOX3 in normal lung was 25, 44, and 88%lower, respectively, supporting the premise that reduced promoter activity confers increased susceptibility to methylation during lung carcinogenesis.
Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects.
GeneRIF
Lu et al., Kunshan, China. In Breast Cancer Res Treat, 2011
Polymorphisms of trinucleotide repeat containing 9 gene is associated with breast cancer.
TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex.
GeneRIF
Methner et al., Düsseldorf, Germany. In J Cell Sci, 2011
TOX3 induces transcription in neuron depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex.
Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci.
Impact
GeneRIF
Million Women Study Collaborators et al., Oxford, United Kingdom. In Jama, 2010
findings strengthen the existing evidence that FGFR2-rs2981582 and TNRC9-rs3803662 are predominantly associated with ER-positive breast cancer
Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American women.
GeneRIF
Palmer et al., Boston, United States. In Cancer Epidemiol Biomarkers Prev, 2010
Single nucleotide polymorphism in TOX3 is associated with breast cancer.
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