ENOX2 target for the anticancer isoflavone ME-143.
West Lafayette, United States. In Oncol Res, 2013
ME-143 (NV-143), a synthetic isoflavone under clinical evaluation for efficacy in the management of ovarian and other forms of human cancer, blocked the activity of a cancer-specific and growth-related cell surface ECTO-NOX protein with both oxidative (hydroquinone) and protein disulfide-thiol interchange activity designated ENOX2 (tNOX) and inhibited the growth of cultured cancer cells with EC50s in the range of 20-50 nM.
X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.
Davis, United States. In Clin Exp Immunol, 2012
Identified genes include transcription factors (ARX, HSFX1, ZBED1, ZNF41) and surface antigens (IL1RAPL2, PGRMC1), and pathway analysis suggests their involvement in cell proliferation (PGK1, SMS, UTP14A, SSR4), apoptosis (MTM1), inflammation (ARAF) and oxidative stress (ENOX2).
Cell membrane redox systems and transformation.
West Lafayette, United States. In Antioxid Redox Signal, 1999
In addition, information on a unique tumor-associated nicotinamide adenine dinucleotide (NADH) oxidase (tNOX) protein is reviewed.