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Tyrosine kinase, non-receptor, 1

TNK1, tyrosine kinase, non-receptor 1
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: CAN, apolipoprotein E, Clusterin, Grb2, Bin1
Papers on TNK1
CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease.
Zerr et al., Göttingen, Germany. In J Clin Neurosci, 2014
IL8, LDLR, PICALM, and TNK1 were determined in 40 Alzheimer's disease patients who were observed for 2 to 3 years.
Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.
Saito et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2014
In this study, comprehensive genome-wide, high-throughput cDNA screening for genes regulating ISG expression identified a tyrosine kinase nonreceptor 1 (TNK1) as a unique player in the ISG induction pathway.
Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity.
Kuster et al., Freising, Germany. In J Proteome Res, 2013
Our data confirmed Aurora A, B, and BCR-ABL as the main targets of tozasertib and identified TNK1, STK2, RPS6KA1, and RPS6KA3 as submicromolar off targets.
Testosterone-induced persistent susceptibility to Plasmodium chabaudi malaria: long-term changes of lincRNA and mRNA expression in the spleen.
Wunderlich et al., Riyadh, Saudi Arabia. In Steroids, 2013
The only exception is the Tnk1-mRNA encoding the non-receptor tyrosine kinase 1 that is persistently downregulated by 0.34-fold after T-withdrawal and that becomes upregulated by 5.9-fold upon infection at peak parasitemia, suggesting an involvement of tyrosine phosphorylation by Tnk1 in mediating long-term effects of T in the spleen.
Comparative analysis of gene transcripts for cell signaling receptors in bone marrow-derived hematopoietic stem/progenitor cell and mesenchymal stromal cell populations.
Davis et al., In Stem Cell Res Ther, 2012
Eleven transcripts were equally expressed (<2-fold upregulation) in HSPCs and BMMSCs (Flt1, Insr, Kdr, Jak1, Agtrl1, Ccr3, Ednrb, Il3ra, Hoxb4, Tnfrsf1a, and Abcb1b), whilst another seven transcripts (Epha6, Epha8, Musk, Ntrk2, Ros1, Srms, and Tnk1) were not expressed in either cell population.
Global tyrosine kinome profiling of human thyroid tumors identifies Src as a promising target for invasive cancers.
Ruan et al., Boston, United States. In Biochem Biophys Res Commun, 2012
RESULTS: Tyrosine kinome profiling demonstrated upregulation of nine tyrosine kinases in tumors relative to matched normal thyroid tissue: EGFR, PTK6, BTK, HCK, ABL1, TNK1, GRB2, ERK, and SRC.
Alzheimer's disease: genetic polymorphisms and rate of decline.
Zerr et al., Göttingen, Germany. In Dement Geriatr Cogn Disord, 2011
IL8, LDLR, PICALM, TNK1) of 40 Alzheimer's disease patients from a longitudinal study were analyzed.
High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells.
GeneRIF
Azorsa et al., Scottsdale, United States. In Mol Cancer Res, 2011
The application of functional genomics by using high-throughput-RNAi screens has allowed us to identify TNK1 as a growth-associated kinase in pancreatic cancer cells.
RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5.
Stewart et al., Scottsdale, United States. In Blood, 2011
When suppressed, the strongest bortezomib sensitizers were the proteasome subunits PSMA5, PSMB2, PSMB3, and PSMB7 providing internal validation, but others included BAZ1B, CDK5, CDC42SE2, MDM4, NME7, RAB8B, TFE3, TNFAIP3, TNK1, TOP1, VAMP2, and YY1.
Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease.
Younkin et al., Jacksonville, United States. In Hum Genet, 2011
To evaluate other promising LOAD candidate genes, we have added data from our large, case-control series (n=5,043) to meta-analyses of all published follow-up case-control association studies for six LOAD candidate genes that have shown significant association across multiple studies (TNK1, GAB2, LOC651924, GWA_14q32.13,
Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways.
Serretti et al., Bologna, Italy. In Int J Alzheimers Dis, 2010
This produced a list of 15 top-rated genes: APOE, CLU, PICALM, EXOC3L2, BIN1, CR1, SORL1, TNK1, IL8, LDLR, CST3, CHRNB2, SORCS1, TNF, and CCR2.
Identification of activated Tnk1 kinase in Hodgkin's lymphoma.
GeneRIF
Polakiewicz et al., In Leukemia, 2010
Activated Tnk1 kinase is associated with Hodgkin's lymphoma.
Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.
Lambert et al., Lille, France. In J Alzheimers Dis, 2009
In the remaining ten genes/loci (TNK1, ACE, CST3, IL1B, hCG2039140, PRNP, GAB2, LOC651924, IL1A, and TF), no single nucleotide polymorphisms were associated in our dataset.
Tnk1/Kos1: a novel tumor suppressor.
Review
Oh et al., Gainesville, United States. In Trans Am Clin Climatol Assoc, 2009
Tnk1/Kos1 is a non-receptor protein tyrosine kinase implicated in negative regulation of cell growth by a mechanism involving inhibition of Ras activation and requiring Tnk1/Kos1's intrinsic catalytic activity.
Genome-wide association studies in Alzheimer's disease.
Review
Tanzi et al., Berlin, Germany. In Hum Mol Genet, 2009
On the basis of the data available at the time of this writing, the most compelling novel GWAS signal has been observed in GAB2 (GRB2-associated binding protein 2), followed by less consistently replicated signals in galanin-like peptide (GALP), piggyBac transposable element derived 1 (PGBD1), tyrosine kinase, non-receptor 1 (TNK1).
Identification of protein tyrosine kinases with oncogenic potential using a retroviral insertion mutagenesis screen.
Cools et al., Leuven, Belgium. In Haematologica, 2009
Using this strategy with the IL3 dependent Ba/F3 cell line, we identified 8 different protein tyrosine kinases (Abl1, Fgfr1, Hck, Jak2, Lck, Mertk, Mst1r, Tnk1) that transformed the cells.
Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation.
GeneRIF
Seufferlein et al., Ulm, Germany. In Oncogene, 2007
TNK1 therefore acts as a novel molecular switch that can determine the properties of TNFalpha signaling and therefore cell death.
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