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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

TRAF2 and NCK interacting kinase

TNIK
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Nck, TRAF2, CAN, Rap2, PAK1
Papers on TNIK
Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK.
New
Ehlers et al., Worcester, United States. In J Pharmacol Exp Ther, Feb 2016
Traf2- and Nck-interacting kinase (TNIK) is a serine/threonine kinase highly expressed in the brain and enriched in the postsynaptic density of glutamatergic synapses in the mammalian brain.
Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade.
New
Peng et al., Taipei, Taiwan. In J Neurosci, Jan 2016
Here, we report that the abundance of tumor necrosis factor receptor-associated factor 2 and NcK-interacting kinase (TNIK), a kinase that is presumed to regulate neural plasticity, was specifically enhanced in ipsilateral dorsal horn neurons after spinal nerve ligation (SNL; left L5 and L6).
From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
New
Ratti et al., Milano, Italy. In Biochim Biophys Acta, Dec 2015
In particular, TDP-43 and FUS were found to regulate splicing and expression of genes related to neuronal (SEPT6, SULT4A1, TNIK) and RNA metabolism (DICER, ELAVL3/HuC, POLDIP3).
Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer.
Review
New
Yamada et al., Tokyo, Japan. In Pharmacol Ther, Dec 2015
Traf2- and Nck-interacting protein kinase (TNIK) has been identified as a regulatory component of the T-cell factor-4 and β-catenin transcriptional complex independently by two research groups.
Targeting the Wnt signaling pathway in colorectal cancer.
New
Yamada et al., Kōbe, Japan. In Expert Opin Ther Targets, Nov 2015
TRAF2 and NCK-interacting protein kinase (TNIK) was identified as the most downstream regulator of Wnt signaling by two independent research groups, and several classes of small-molecule inhibitors targeting this protein kinase have been developed.
Organization of TNIK in dendritic spines.
New
Weinberg et al., Chapel Hill, United States. In J Comp Neurol, Oct 2015
Tumor necrosis factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1).
TNIK serves as a novel biomarker associated with poor prognosis in patients with pancreatic cancer.
New
Wang et al., Hohhot, China. In Tumour Biol, Sep 2015
UNASSIGNED: Traf-2 and Nck interacting kinase (TNIK) is one of the STE20/MAP4K family members implicated in carcinogenesis and progression of several human malignancies.
Silencing of STRN4 suppresses the malignant characteristics of cancer cells.
Senga et al., Nagoya, Japan. In Cancer Sci, 2014
We previously reported that STRN4 directly associated with protein kinases, such as MINK1, TNIK and MAP4K4, which are associated with tumor suppression or tumor progression.
Epigenetic regulation of traf2- and Nck-interacting kinase (TNIK) in polycystic ovary syndrome.
Wang et al., Shenyang, China. In Am J Transl Res, 2014
Emerging evidence has led to considerable interest in the role of Traf2- and Nck-interacting kinase (TNIK) in polycystic ovary syndrome (PCOS) development.
Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer.
Sugihara et al., Tokyo, Japan. In Bmc Cancer, 2014
Thus, we identified seventeen candidate genes, and selected Traf2- and Nck-interacting kinase (TNIK), which was known to be associated with progression in CRC through Wnt signaling pathways.
A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells.
Kim et al., Taejŏn, South Korea. In Plos One, 2013
Traf2- and Nck-interacting kinase (TNIK) has recently been considered as a first-in-class anti-cancer target molecule to regulate Wnt signaling pathway, but pharmacologic inhibition of its EMT activity has not yet been studied.
Rap2A links intestinal cell polarity to brush border formation.
Impact
Bos et al., Utrecht, Netherlands. In Nat Cell Biol, 2012
The subsequent recruitment of phospholipase D1 allows polarized accumulation of phosphatidic acid, which provides a local cue for successive signalling by the guanine nucleotide exchange factor PDZGEF, the small G protein Rap2A, its effector TNIK, the kinase MST4 and, ultimately, the actin-binding protein Ezrin.
DISC1-binding proteins in neural development, signalling and schizophrenia.
Review
Porteous et al., Edinburgh, United Kingdom. In Neuropharmacology, 2012
APP, Dixdc1, LIS1, NDE1, NDEL1), neural progenitor proliferation (GSK3β), neurosignalling (Girdin, GSK3β, PDE4) and synaptic function (Kal7, TNIK).
The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.
GeneRIF
Brandon et al., Princeton, United States. In Mol Psychiatry, 2011
TNIK maintains levels of glutamate receptors and other key postsynaptic density (PSD) proteins at the synapse, with loss of TNIK protein or inhibition of TNIK activity causing rapid degradation of PSD constituents.
Enormous influence of TNIK knockdown on intracellular signals and cell survival.
GeneRIF
Zhou et al., Hangzhou, China. In Hum Cell, 2011
TNIK is essential for the activation of both the canonical Wnt pathway and the JNK pathway, and serves as a pro-survival factor.
Identifying gene regulatory networks in schizophrenia.
Review
Xie et al., Irvine, United States. In Neuroimage, 2010
Several of these genes (RSRC1, ARHGAP18, ROBO1-ROBO2, GPC1, TNIK, and CTXN3-SLC12A2) have functions related to progenitor cell proliferation, migration, and differentiation, cytoskeleton reorganization, axonal connectivity, and development of forebrain structures.
Psychiatric disorders: The risk of DISC — at the synapse.
Impact
Danovi, In Nat Rev Neurosci, 2010
DISC1 negatively regulates synaptic strength by inhibiting the TNIK-dependent stabilization of postsynaptic proteins.
The kinase TNIK is an essential activator of Wnt target genes.
GeneRIF
Clevers et al., Utrecht, Netherlands. In Embo J, 2009
siRNA depletion of TNIK followed by expression array analysis showed that TNIK is an essential, specific activator of Wnt transcriptional programme.
The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.
GeneRIF
Kariya et al., Okinawa, Japan. In J Biol Chem, 2004
TNIK is a specific effector of Rap2 to regulate actin cytoskeleton
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