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TNF receptor-associated factor 1

TNF Receptor-Associated Factor 1, TRAF1
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: NF-kappaB, TRAF2, CAN, IgM, PTPN22
Papers using TNF Receptor-Associated Factor 1 antibodies
NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
Supplier
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2002
... Antibodies against p65, pan-IκBα, Bcl-2, Bcl-xL and TNF-α receptor-associated factor 1 (TRAF1) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kB activation prevents cell death
Supplier
Choi Yongwon et al., In The Journal of Experimental Medicine, 1995
... Generation of TRAF1 Transgenic Mice.
Papers on TNF Receptor-Associated Factor 1
Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks.
New
Furlong et al., Heidelberg, Germany. In Curr Biol, Feb 2016
Second, over 70% of loci do not follow the simple situation of having only two shadow enhancers-often there are three (rols), four (CadN and ade5), or five (Traf1), at least one of which can be deleted with no obvious phenotypic effects.
Tumor necrosis factor receptor-associated factor 1 (TRAF1) polymorphisms and susceptibility to autoimmune thyroid disease.
New
Xu et al., Shanghai, China. In Autoimmunity, Jan 2016
UNASSIGNED: Former studies have revealed the link between the tumor necrosis factor (TNF) receptor-associated factor 1 (TRAF1) polymorphisms and autoimmunity.
A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels.
New
Kurreeman et al., Leiden, Netherlands. In Genes Immun, Jan 2016
The TRAF1 and C5 risk locus shows evidence of multiple eQTLs and transcription of intergenic non-coding sequences.
Single nucleotide polymorphisms in AGTR1, TFAP2B, and TRAF1 are not associated with the incidence of patent ductus arteriosus in Japanese preterm infants.
New
Saitoh et al., Nagoya, Japan. In Pediatr Int, Dec 2015
Single nucleotide polymorphisms (SNPs) in several genes, including angiotensin II receptor, type 1 (AGTR1), transcription factor AP-2 beta (TFAP2B) and TNF receptor-associated factor 1 (TRAF1), have been reported to be associated with the incidence of patent ductus arteriosus in preterm infants.
[Progress of molecular genetics research on rheumatoid arthritis].
Review
New
Zhang et al., Nanchong, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Oct 2015
In addition to genes from human leukocyte antigen (HLA) region, such as HLA-DRB, genes from non-HLA region, such as TIM-3, PTPN22, TRAF1/C5, STAT4, CCR5, PADI4 and FCGR2A may also contribute to its susceptibility.
Epstein-Barr virus latency: current and future perspectives.
Review
New
Robertson et al., München, Germany. In Curr Opin Virol, Oct 2015
We broadly describe the transcription, epigenetic, signaling and super-enhancer functions of the latent nuclear antigens in regulating cellular transcription; the role of LMP2 in utilization of the autophagosome to control cell death, and the association between LMP1, the linear ubiquitin chain assembly complex and TRAF1 which are important for transformation.
Fitting Proportional Odds Model to Case-Control data with Incorporating Hardy-Weinberg Equilibrium.
Li et al., Beijing, China. In Sci Rep, 2014
Application to 45 single nucleotide polymorphisms located in the region of TRAF1-C5 genes for the association with four-level anticyclic citrullinated protein antibody from Genetic Analysis Workshop 16 further demonstrates its performance.
TNF Receptor-Associated Factor (TRAF) Signaling Network in CD4(+) T-Lymphocytes.
Review
Ishii et al., In Tohoku J Exp Med, 2014
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs), which are composed of six TRAF proteins (TRAF1-TRAF6) with a conserved C-terminal TRAF domain, are intracellular signaling adaptors that mediate the link between receptor-proximal activation events and intracellular signaling proteins.
TRAF4 mediates activation of TGF-β signaling and is a biomarker for oncogenesis in breast cancer.
Review
Zhang et al., Hangzhou, China. In Sci China Life Sci, 2014
In mammals, there are six distinct members in the tumor-necrosis factor receptor (TNFR)-associated factor (TRAF) family (TRAF1-TRAF6), with the function of TRAF4 not being extensively studied in the past decade.
Genetics of rheumatoid arthritis - a comprehensive review.
Review
Szekanecz et al., Debrecen, Hungary. In Clin Rev Allergy Immunol, 2013
The most relevant non-HLA gene single nucleotide polymorphisms (SNPs) associated with RA include PTPN22, IL23R, TRAF1, CTLA4, IRF5, STAT4, CCR6, PADI4.
Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts.
GeneRIF
van der Helm-van Mil et al., In Ann Rheum Dis, 2012
the present data do not support the initial findings that single-nucleotide polymorphisms of TRAF1-C5 and TNFAIP3-OLIG3 rare associated with the severity of joint destruction in RA.
Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells.
GeneRIF
Watts et al., Toronto, Canada. In J Biol Chem, 2012
TRAF1 plays a critical role in regulating T cell activation both through restricting the costimulation independent activation of NIK in activated T cells and by promoting the 4-1BB-induced classical NF-kappaB pathway.
Association study of TRAF1-C5 polymorphism with susceptibility to rheumatoid arthritis in Tunisian population.
GeneRIF
Hamzaoui et al., In Joint Bone Spine, 2012
We confirmed the positive association of rs10818488 A allele with rheimatoid arthritis in Tunisia.
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.
GeneRIF
Watts et al., Toronto, Canada. In J Exp Med, 2012
These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 T cell fitness during the chronic phase of disease and a target for therapy.
Influence of TRAF1/C5 and STAT4 genes polymorphisms on susceptibility and severity of rheumatoid arthritis in Egyptian population.
GeneRIF
El-Shahawy et al., Az Zaqāzīq, Egypt. In Cell Immunol, 2011
TRAF1 polymorphisms contribute to rheumatoid arthritis susceptibility, activity, and severity in an Egyption population.
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
Impact
Siminovitch et al., Long Beach, United States. In Nat Genet, 2009
c-Rel is an NF-kappaB family member with distinct functional properties in hematopoietic cells, and its association with rheumatoid arthritis suggests disease pathways that involve other recently identified rheumatoid arthritis susceptibility genes including CD40, TRAF1, TNFAIP3 and PRKCQ.
The immunopathogenesis of rheumatoid arthritis.
Review
Impact
Imboden, San Francisco, United States. In Annu Rev Pathol, 2008
Five risk loci have been identified and validated: HLA-DRB1, PTPN22, STAT4, a region in 6q23, and the TRAF1/C5 locus.
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
Impact
Plenge et al., Cambridge, United States. In Nat Genet, 2008
Along with other associations near TRAF1 (refs.
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
Impact
GeneRIF
Gregersen et al., Cambridge, United States. In N Engl J Med, 2007
A common genetic variant at the TRAF1-C5 locus on chromosome 9 is associated with an increased risk of anti-CCP-positive rheumatoid arthritis.
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer.
Impact
Hung et al., Houston, United States. In Cancer Cell, 2002
Importantly, activated beta-catenin was found to inhibit the expression of NF-kappa B target genes, including Fas and TRAF1.
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