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TNF receptor-associated factor 1

TNF Receptor-Associated Factor 1, TRAF1
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Papers using TNF Receptor-Associated Factor 1 antibodies
NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2002
... Antibodies against p65, pan-IκBα, Bcl-2, Bcl-xL and TNF-α receptor-associated factor 1 (TRAF1) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kB activation prevents cell death
Choi Yongwon et al., In The Journal of Experimental Medicine, 1995
... Generation of TRAF1 Transgenic Mice.
Papers on TNF Receptor-Associated Factor 1
Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts.
van der Helm-van Mil et al., In Ann Rheum Dis, 2012
the present data do not support the initial findings that single-nucleotide polymorphisms of TRAF1-C5 and TNFAIP3-OLIG3 rare associated with the severity of joint destruction in RA.
Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells.
Watts et al., Toronto, Canada. In J Biol Chem, 2012
TRAF1 plays a critical role in regulating T cell activation both through restricting the costimulation independent activation of NIK in activated T cells and by promoting the 4-1BB-induced classical NF-kappaB pathway.
Association study of TRAF1-C5 polymorphism with susceptibility to rheumatoid arthritis in Tunisian population.
Hamzaoui et al., In Joint Bone Spine, 2012
We confirmed the positive association of rs10818488 A allele with rheimatoid arthritis in Tunisia.
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.
Watts et al., Toronto, Canada. In J Exp Med, 2012
These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 T cell fitness during the chronic phase of disease and a target for therapy.
Influence of TRAF1/C5 and STAT4 genes polymorphisms on susceptibility and severity of rheumatoid arthritis in Egyptian population.
El-Shahawy et al., Az Zaqāzīq, Egypt. In Cell Immunol, 2011
TRAF1 polymorphisms contribute to rheumatoid arthritis susceptibility, activity, and severity in an Egyption population.
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