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Transmembrane protease, serine 3

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: CAN, Cx26, HAD, POLYMERASE, E-cadherin
Papers on TMPRSS3
TMPRSS4 induces cancer stem cell-like properties in lung cancer cells and correlates with ALDH expression in NSCLC patients.
Calvo et al., Pamplona, Spain. In Cancer Lett, Feb 2016
The type II transmembrane serine protease TMPRSS4 is highly expressed in some solid tumors, promotes metastasis and confers EMT features to cancer cells.
TMPRSS4 Expression as a Marker of Recurrence in Patients with Lung Cancer.
Tanaka et al., Kitakyūshū, Japan. In Anticancer Res, Jan 2016
Among them, we selected transmembrane protease, serine 4 (TMPRSS4) and identified positive expression of TMPRSS4 in 93 (57.8%) patients.
TMPRSS3 modulates ovarian cancer cell proliferation, invasion and metastasis.
Zheng et al., Harbin, China. In Oncol Rep, Jan 2016
Overexpression of transmembrane protease, serine 3 (TMPRSS3) has been detected in ovarian cancer.
Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.
Becker-Pauly et al., Kiel, Germany. In Biochem J, Sep 2015
We show that MT2, but not TMPRSS4 or pancreatic trypsin, is capable of activating full-length meprin β at the cell surface, analysed by specific fluorogenic peptide cleavage assay, Western blotting and confocal laser scanning microscopy (CLSM).
Molecular Distribution of Deafness Loci in Various Ethnic Groups of the Punjab, Pakistan.
Rasheed et al., Lahore, Pakistan. In J Coll Physicians Surg Pak, Aug 2015
Three families (SAPun-03, SAPun-10 and SAPun-15) were found linked to DFNB12; two families (SAPun-05 and SAPun-17) were found linked to DFNB8/10, while three families (SAPun-06, SAPun-13 and SAPun-19) were found linked to DFNB29, DFNB36 and DFNB37 respectively.
Comprehensive analysis via exome sequencing uncovers genetic etiology in autosomal recessive nonsyndromic deafness in a large multiethnic cohort.
Tekin et al., Miami, United States. In Genet Med, Aug 2015
The most common genes with mutations were MYO15A (13%), MYO7A (11%), SLC26A4 (10%), TMPRSS3 (9%), TMC1 (8%), ILDR1 (6%), and CDH23 (4%).
Survival of Cochlear Spiral Ganglion Neurons Improved In Vivo by Anti-miR204 via TMPRSS3.
Liu et al., Taiwan. In West Indian Med J, Jun 2015
Moreover, expression of TMPRSS3 in SGNs was saved by anti-miR204 treatment.
TMPRSS4: an emerging potential therapeutic target in cancer.
Calvo et al., Pamplona, Spain. In Br J Cancer, Feb 2015
The transmembrane protease, serine 4 (TMPRSS4) is closely related to other cancer-associated proteases, such as hepsin, TMPRSS2 and matriptase.
TMPRSS3 is a novel poor prognostic factor for breast cancer.
Li et al., Shenyang, China. In Int J Clin Exp Pathol, 2014
It has recently been reported that transmembrane protease, serine 3 (TMPRSS3) is overexpressed in cancer.
TMPRSS4 facilitates epithelial-mesenchymal transition of hepatocellular carcinoma and is a predictive marker for poor prognosis of patients after curative resection.
Li et al., Jinan, China. In Sci Rep, 2014
TMPRSS4 (Transmembrane protease serine 4) is up-regulated in a broad spectrum of cancers.
Function and clinical relevance of kallikrein-related peptidases and other serine proteases in gynecological cancers.
Magdolen et al., München, Germany. In Crit Rev Clin Lab Sci, 2014
Expression/activity levels of other Ser-proteases, including the type II transmembrane Ser-proteases (TTSPs) matriptase, hepsin (TMPRSS1), and the hepsin-related protease (TMPRSS3), as well as the glycosyl-phosphatidylinositol (GPI)-anchored Ser-proteases prostasin and testisin, may be of clinical relevance in gynecological cancers.
Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5.
Lee et al., Taejŏn, South Korea. In Genomics Inform, 2014
The epithelial-mesenchymal transition (EMT) is one mechanism by which cells with mesenchymal features can be generated and is a fundamental event in morphogenesis.
TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections.
Becker-Pauly et al., Mainz, Germany. In Biol Chem, 2012
This minireview summarizes the up-to-date knowledge about the still growing TTSPs, particularly focusing on the pathophysiological functions of the family member type II transmembrane serine protease (TMPRSS) 4. Recent studies provided important data on TMPRSS4 activity associated with the spreading of influenza viruses, mediated by the cleavage of hemagglutinin.
A novel genome-based approach correlates TMPRSS3 overexpression in ovarian cancer with DNA hypomethylation.
Bachvarov et al., Québec, Canada. In Gynecol Oncol, 2012
Data imply that TMPRSS3-A/D overexpression in EOC is probably due to hypomethylation of their control region.
Molecular analysis of the TMPRSS3 gene in Moroccan families with non-syndromic hearing loss.
Barakat et al., Casablanca, Morocco. In Biochem Biophys Res Commun, 2012
TMPRSS3 gene is not a major contributor to non-syndromic deafness in the Moroccan population.
Genotype-phenotype correlation in DFNB8/10 families with TMPRSS3 mutations.
Kunst et al., Nijmegen, Netherlands. In J Assoc Res Otolaryngol, 2011
Our data suggest that not only the protein truncating mutation p.T70fs has a severe effect but also the amino acid substitutions p.Ala306Thr and p.Val199Met.
Autosomal recessive nonsyndromic deafness genes: a review.
Tekin et al., Ankara, Turkey. In Front Biosci, 2011
Other relatively common deafness genes include SLC26A4, MYO15A, OTOF, TMC1, CDH23, and TMPRSS3.
Overexpression of TMPRSS4 in non-small cell lung cancer is associated with poor prognosis in patients with squamous histology.
Calvo et al., Pamplona, Spain. In Br J Cancer, 2011
Kaplan-Meier curves demonstrated that high levels of TMPRSS4 were significantly associated (P=0.017) with reduced overall survival in the patients with SCC histology, whereas no correlation was found for the AC histology
[Expression of proteinase TMPRSS3 in mouse cochlea].
Xie et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011
The distribution of TMPRSS3 was observed in many regions of the mouse cochlea, but mainly in the spiral ganglion neurons.
Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness.
Antonarakis et al., Genève, Switzerland. In Nat Genet, 2001
Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.
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