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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Tropomyosin 3

TM3, Tropomyosin, TM5, TPM3
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Actin, ACID, HAD, Tropomyosin
Papers using TM3 antibodies
Oxidative stress-induced posttranslational modification of proteins as a target of functional food
Yoshikawa Toshikazu et al., In Journal of Clinical Biochemistry and Nutrition, 2008
... Tropomyosin-1 (TPM1) monoclonal antibody (D12H4, XP Rabbit) and Horseradish peroxidase (HRP)-linked anti-rabbit IgG were purchased from Cell Signaling (Beverly, MA) ...
Follicular cells acquire sertoli cell characteristics after oocyte loss
Tremblay Jacques J et al., In BMC Developmental Biology, 2004
... Total RNA from MA-10, mLTC-1, TM3 and R2C Leydig cell lines was extracted using the RNeasy Plus extraction kit (Qiagen, Mississauga, Ontario, Canada) and ...
Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy
Hardeman Edna C. et al., In The Journal of Cell Biology, 1984
... Generation of the Tropomyosin-3 (Tm3) transgenic mouse ...
Papers on TM3
Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition.
Schirrmacher et al., Edmonton, Canada. In Expert Opin Ther Pat, 11 Dec 2015
UNASSIGNED: Tropomyosin receptor kinases (TrkA/B/C) are involved in the development and maintenance of the nervous system.
Cloning and characterization of tropomyosin from the mite Chortoglyphus arcuatus.
Carnés et al., Tres Cantos, Spain. In Mol Immunol, 29 Nov 2015
UNASSIGNED: Tropomyosin is a pan-allergen that shares a high homology among species.
Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity.
Furnham et al., Cambridge, United Kingdom. In Plos Comput Biol, 31 Oct 2015
Nearly half of these parasite proteins from 31 species fall within the 10 most abundant allergenic protein domain families (EF-hand, Tropomyosin, CAP, Profilin, Lipocalin, Trypsin-like serine protease, Cupin, BetV1, Expansin and Prolamin).
Phylogenetic conservation of protein-lipid motifs in pentameric ligand-gated ion channels.
Barrantes, Buenos Aires, Argentina. In Biochim Biophys Acta, Sep 2015
The evolutionarily conserved design is manifested in: 1) the concentric three-ring architecture of the transmembrane region, 2) the occurrence in this region of distinct lipid consensus motifs in prokaryotic and eukaryotic pLGIC and 3) the key participation of the outer TM4 ring in conveying the influence of the lipid membrane environment to the middle TM1-TM3 ring and this, in turn, to the inner TM2 channel-lining ring, which determines the ion selectivity of the channel.
Propagation of conformational changes during μ-opioid receptor activation.
Granier et al., Montpellier, France. In Nature, Sep 2015
Our results show that conformational changes in transmembrane segments 5 and 6 (TM5 and TM6), which are required for the full engagement of a G protein, are almost completely dependent on the presence of both the agonist and the G protein mimetic nanobody, revealing a weak allosteric coupling between the agonist-binding pocket and the G-protein-coupling interface (TM5 and TM6), similar to that observed for the β2-adrenergic receptor.
Tropomyosin - master regulator of actin filament function in the cytoskeleton.
Mulvihill et al., Sydney, Australia. In J Cell Sci, Sep 2015
Tropomyosin (Tpm) isoforms are the master regulators of the functions of individual actin filaments in fungi and metazoans.
PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.
Yan et al., Beijing, China. In Science, Aug 2015
Each protomer comprises six transmembrane segments (TMs), with TM3 and TM4 contributing to homotrimerization.
Structure of the F-actin-tropomyosin complex.
Raunser et al., Dortmund, Germany. In Nature, Apr 2015
In striated muscle fibres, the binding of myosin motors to actin filaments is mainly regulated by tropomyosin and troponin.
TRKing down an old oncogene in a new era of targeted therapy.
Doebele et al., Aurora, United States. In Cancer Discov, Jan 2015
These recent developments have led us to revisit an old oncogene, Trk (originally identified as OncD), which encodes the TPM3-NTRK1 gene fusion and was one of the first transforming chromosomal rearrangements identified 32 years ago.
Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
MacKinnon et al., New York City, United States. In Nature, Jan 2015
Additional rotation of a membrane interacting TM2-TM3 segment, unique to mechanosensitive K2Ps, against TM4 may further stabilize the conductive conformation.
Tropomyosin, the major tropical oyster Crassostrea belcheri allergen and effect of cooking on its allergenicity.
Murad et al., Kuala Lumpur, Malaysia. In Allergy Asthma Clin Immunol, Dec 2014
Mass spectrometry analysis of the 37 kDa major allergen identified this spot as tropomyosin.
Anchored multiplex PCR for targeted next-generation sequencing.
Le et al., Boston, United States. In Nat Med, Dec 2014
On the basis of our experience with performing AMP on 986 clinical FFPE samples, we show its potential as both a robust clinical assay and a powerful discovery tool, which we used to identify new therapeutically important gene fusions: ARHGEF2-NTRK1 and CHTOP-NTRK1 in glioblastoma, MSN-ROS1, TRIM4-BRAF, VAMP2-NRG1, TPM3-NTRK1 and RUFY2-RET in lung cancer, FGFR2-CREB5 in cholangiocarcinoma and PPL-NTRK1 in thyroid carcinoma.
Molecular Insights into the Transmembrane Domain of the Thyrotropin Receptor.
Chabbert et al., Angers, France. In Plos One, Dec 2014
Evolutionary analysis of the LGR family revealed a deletion in TM5 but provided no information on TM2.
Congenital myopathy with cap-like structures and nemaline rods: case report and literature review.
MacKenzie et al., Kingston, Canada. In Pediatr Neurol, Aug 2014
Molecular genetic testing was performed for NEB, TPM2, TPM3, ACTA1, TNNT1, SEPN1, SMN1, DMPK, FSHMD1A, and mtDNA.
Expression of tropomyosin in relation to myofibrillogenesis in axolotl hearts.
Dube et al., Syracuse, United States. In Regen Med Res, 2013
Studies have shown a differential expression of tropomyosin between the conus and the ventricle indicating two different cardiac segments.
Identification and validation of novel serum markers for early diagnosis of endometriosis.
Khole et al., Mumbai, India. In Hum Reprod, 2012
investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TPM3, stomatin-like protein 2, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified.
Molecular diagnosis and targeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion.
Tse et al., Xiamen, China. In Pediatr Blood Cancer, 2011
High TPM3-PDGFRB fusion protein expression is associated with chronic eosinophilic leukemia.
Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.
Solaro et al., Chicago, United States. In J Muscle Res Cell Motil, 2011
The results identify a novel mode of myofilament desensitization to Ca(2+) associated with a DCM linked switch in TPM1-kappa.
Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments.
Stehn et al., Westmead, Australia. In Exp Cell Res, 2011
variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations
Congenital fibre type disproportion associated with mutations in the tropomyosin 3 (TPM3) gene mimicking congenital myasthenia.
Muntoni et al., London, United Kingdom. In Neuromuscul Disord, 2010
study reports clinico-pathological and electrophysiological features of 2 unrelated cases with heterozygous TPM3 mutation; cases highlight neuromuscular transmission defect in congenital myopathy with fibre type disproportion secondary to TPM3 mutations
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