ALK-Rearranged Renal Cell Carcinomas in Children.
Omaha, United States. In Genes Chromosomes Cancer, Feb 2016
Further investigation revealed ALK rearrangements in all cases, manifested molecularly by fusion transcripts of either VCL-ALK (3 patients all with sickle cell trait which had been previously reported) or TPM3-ALK (3 patients, none with sickle cell trait).
Phylogenetic conservation of protein-lipid motifs in pentameric ligand-gated ion channels.
Buenos Aires, Argentina. In Biochim Biophys Acta, Sep 2015
The evolutionarily conserved design is manifested in: 1) the concentric three-ring architecture of the transmembrane region, 2) the occurrence in this region of distinct lipid consensus motifs in prokaryotic and eukaryotic pLGIC and 3) the key participation of the outer TM4 ring in conveying the influence of the lipid membrane environment to the middle TM1-TM3 ring and this, in turn, to the inner TM2 channel-lining ring, which determines the ion selectivity of the channel.
Propagation of conformational changes during μ-opioid receptor activation.
Montpellier, France. In Nature, Sep 2015
Our results show that conformational changes in transmembrane segments 5 and 6 (TM5 and TM6), which are required for the full engagement of a G protein, are almost completely dependent on the presence of both the agonist and the G protein mimetic nanobody, revealing a weak allosteric coupling between the agonist-binding pocket and the G-protein-coupling interface (TM5 and TM6), similar to that observed for the β2-adrenergic receptor.
TRKing down an old oncogene in a new era of targeted therapy.
Aurora, United States. In Cancer Discov, 2015
These recent developments have led us to revisit an old oncogene, Trk (originally identified as OncD), which encodes the TPM3-NTRK1 gene fusion and was one of the first transforming chromosomal rearrangements identified 32 years ago.