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Tropomyosin 3

TM3, Tropomyosin, TM5, TPM3
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Actin, ACID, HAD, Tropomyosin
Papers using TM3 antibodies
Oxidative stress-induced posttranslational modification of proteins as a target of functional food
Yoshikawa Toshikazu et al., In Journal of Clinical Biochemistry and Nutrition, 2008
... Tropomyosin-1 (TPM1) monoclonal antibody (D12H4, XP Rabbit) and Horseradish peroxidase (HRP)-linked anti-rabbit IgG were purchased from Cell Signaling (Beverly, MA) ...
Follicular cells acquire sertoli cell characteristics after oocyte loss
Tremblay Jacques J et al., In BMC Developmental Biology, 2004
... Total RNA from MA-10, mLTC-1, TM3 and R2C Leydig cell lines was extracted using the RNeasy Plus extraction kit (Qiagen, Mississauga, Ontario, Canada) and ...
Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy
Hardeman Edna C. et al., In The Journal of Cell Biology, 1984
... Generation of the Tropomyosin-3 (Tm3) transgenic mouse ...
Papers on TM3
In silico study of the structurally similar ORL1 receptor agonist and antagonist pairs reveal possible mechanism of receptor activation.
Dosen-Mićović et al., In Protein J, Jun 2014
It was established that agonists and antagonists bound to the same, relatively large, binding site in the receptor, created by residues from transmembrane helices TM2, TM3, TM5, TM6 and TM7 and close to the extra cellular end of the receptor bundle.The key difference between these two types of ligands is interaction with residue Val283(6.55)
Congenital fiber type disproportion myopathy caused by LMNA mutations.
Hayashi et al., Tokyo, Japan. In J Neurol Sci, Jun 2014
Importantly, all FTD associated with LMNA-myopathy were caused by hypertrophy of type 2 fibers as compared with age-matched controls, whereas CFTD with mutations in ACTA1 or TPM3 showed selective type 1 fiber atrophy but no type 2 fiber hypertrophy.
Toward activated homology models of the human M1 muscarinic acetylcholine receptor.
Doughty et al., Kuala Lumpur, Malaysia. In J Mol Graph Model, Apr 2014
Virtual screening experiments showed that all three refined models could efficiently differentiate agonists from decoy molecules, with the TM5-modified models also giving good agonist/antagonist selectivity.
Getting myosin-V on the right track: tropomyosin sorts transport in yeast.
Lord et al., Burlington, United States. In Bioarchitecture, Jan 2014
Recent studies have revealed a novel mechanism of myosin regulation in which the actin-binding protein tropomyosin converts atypical type-V myosins into processive cargo transporters.
Sex-dependent genetic effects on immune responses to a parasitic nematode.
Grencis et al., Manchester, United Kingdom. In Bmc Genomics, Dec 2013
A significant QTL on chromosome 5 (TM5) associated with IFN-γ production was found in male mice but not in female mice.
Differential stability of the crystallographic interfaces of mu- and kappa-opioid receptors.
Filizola et al., New York City, United States. In Plos One, Dec 2013
The recent mu-opioid receptor (MOPr) and kappa-opioid receptor (KOPr) crystal structures have inspired hypotheses of physiologically relevant dimerization contacts, specifically: a closely packed interface involving transmembrane (TM) helices TM5 and TM6, and a less compact interface, involving TM1, TM2, and helix 8 (H8).
Structural basis for action by diverse antidepressants on biogenic amine transporters.
Gouaux et al., Portland, United States. In Nature, Dec 2013
The chemically diverse inhibitors have a remarkably similar mode of binding in which they straddle transmembrane helix (TM) 3, wedge between TM3/TM8 and TM1/TM6, and lock the transporter in a sodium- and chloride-bound outward-facing open conformation.
Novel small molecule activators of the Trk family of receptor tyrosine kinases.
Ye et al., Atlanta, United States. In Biochim Biophys Acta, Oct 2013
The Tropomyosin-related kinase (Trk) receptors are a subset of the receptor tyrosine kinase family with an important functionality in the regulation of neurotrophic signaling in the peripheral and central nervous system.
Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor.
Handa et al., Phoenix, United States. In Neuroscience, Jul 2013
Additional studies have also documented regulation of the expression of the high-affinity BDNF receptor Tropomyosin-Related Kinase B by estradiol, thus implicating sex steroids not only in the regulation of BDNF expression, but also in mechanisms of signaling associated with it.
Periodicities designed in the tropomyosin sequence and structure define its functions.
Barua, United States. In Bioarchitecture, May 2013
Tropomyosin is an actin binding protein that regulates actin filament dynamics and its interactions with actin binding proteins such as myosin, tropomodulin, formin, Arp2/3 and ADF-cofilin in most eukaryotic cells.
Tropomyosin-receptor-kinases signaling in the nervous system.
Purcaru et al., Craiova, Romania. In Maedica (buchar), Mar 2013
Tropomyosin-receptor-kinase receptor family controls synaptic strength and plasticity in the mammalian nervous system.
Identification and validation of novel serum markers for early diagnosis of endometriosis.
Khole et al., Mumbai, India. In Hum Reprod, 2012
investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TPM3, stomatin-like protein 2, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified.
Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Kobilka et al., Stanford, United States. In Nature, 2011
The largest conformational changes in the β(2)AR include a 14 Å outward movement at the cytoplasmic end of transmembrane segment 6 (TM6) and an α-helical extension of the cytoplasmic end of TM5.
Structure and mechanism of the uracil transporter UraA.
Yan et al., Beijing, China. In Nature, 2011
A pair of antiparallel β-strands is located between TM3 and TM10 and has an important role in structural organization and substrate recognition.
Molecular diagnosis and targeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion.
Tse et al., Xiamen, China. In Pediatr Blood Cancer, 2011
High TPM3-PDGFRB fusion protein expression is associated with chronic eosinophilic leukemia.
Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.
Solaro et al., Chicago, United States. In J Muscle Res Cell Motil, 2011
The results identify a novel mode of myofilament desensitization to Ca(2+) associated with a DCM linked switch in TPM1-kappa.
Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments.
Stehn et al., Westmead, Australia. In Exp Cell Res, 2011
variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations
Congenital fibre type disproportion associated with mutations in the tropomyosin 3 (TPM3) gene mimicking congenital myasthenia.
Muntoni et al., London, United Kingdom. In Neuromuscul Disord, 2010
study reports clinico-pathological and electrophysiological features of 2 unrelated cases with heterozygous TPM3 mutation; cases highlight neuromuscular transmission defect in congenital myopathy with fibre type disproportion secondary to TPM3 mutations
Assembly of endogenous oskar mRNA particles for motor-dependent transport in the Drosophila oocyte.
Ephrussi et al., Heidelberg, Germany. In Cell, 2009
Our analysis uncovers a role for the EJC component Barentsz in recruiting Tropomyosin II (TmII) to oskar particles in the ooplasm and reveals that TmII is required for kinesin binding to the RNPs.
Crystal structure of opsin in its G-protein-interacting conformation.
Ernst et al., Berlin, Germany. In Nature, 2008
GalphaCT binds to a site in opsin that is opened by an outward tilt of transmembrane helix (TM) 6, a pairing of TM5 and TM6, and a restructured TM7-helix 8 kink.
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