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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Oct 2014.

Tropomyosin 3

TM3, Tropomyosin, TM5, TPM3
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Actin, ACID, HAD, Tropomyosin
Papers using TM3 antibodies
Oxidative stress-induced posttranslational modification of proteins as a target of functional food
Supplier
Yoshikawa Toshikazu et al., In Journal of Clinical Biochemistry and Nutrition, 2008
... Tropomyosin-1 (TPM1) monoclonal antibody (D12H4, XP Rabbit) and Horseradish peroxidase (HRP)-linked anti-rabbit IgG were purchased from Cell Signaling (Beverly, MA) ...
Follicular cells acquire sertoli cell characteristics after oocyte loss
Supplier
Tremblay Jacques J et al., In BMC Developmental Biology, 2004
... Total RNA from MA-10, mLTC-1, TM3 and R2C Leydig cell lines was extracted using the RNeasy Plus extraction kit (Qiagen, Mississauga, Ontario, Canada) and ...
Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy
Supplier
Hardeman Edna C. et al., In The Journal of Cell Biology, 1984
... Generation of the Tropomyosin-3 (Tm3) transgenic mouse ...
Papers on TM3
Understanding the effects on constitutive activation and drug binding of a D130N mutation in the β2 adrenergic receptor via molecular dynamics simulation.
New
Pu et al., Chengdu, China. In J Mol Model, 30 Nov 2014
In particular, the mutation leads to the departure of transmembrane 3 (TM3) from transmembrane 6 (TM6) and marked changes in the NPxxY region as well as the complete disruption of a key ionic lock, all of which contribute to the observed constitutive activation.
A helical conformation in the large intracellular domain is required for modulation of the alpha 1 glycine receptor by ethanol and Gβγ
New
Aguayo et al., Concepción, Chile. In J Pharmacol Exp Ther, 22 Nov 2014
The data suggest existence of an alpha-helical conformation in the regions near TM3 and TM4 of the large intracellular domain, in agreement with data obtained from CD.
Development of a Highly Selective Allosteric Antagonist Radioligand for the Type 1 Cholecystokinin Receptor and Elucidation of its Molecular Basis of Binding.
New
Miller et al., United States. In Mol Pharmacol, 15 Nov 2014
Exchanging exonic regions revealed functional importance of CCK1R exon 3, extending from bottom of TM3 to top of TM5, including portions of the intramembranous pocket as well as ECL2.
Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma.
New
Zhang et al., In J Hematol Oncol, 10 Nov 2014
UNLABELLED: BackgroundThe identification of fusion genes such as SYT-SSX1/SSX2, PAX3-FOXO1, TPM3/TPM4-ALK and EWS-FLI1 in human sarcomas has provided important insight into the diagnosis and targeted therapy of sarcomas.
Regulation of a TrkB Alternative Transcript by microRNAs.
New
Wong, Wollongong, Australia. In Dement Geriatr Cogn Dis Extra, 30 Sep 2014
BACKGROUND/AIMS: Tropomyosin-related kinase B receptor (TrkB)-mediated signaling is vital for neuronal differentiation, survival, plasticity, and cognition.
Processing properties of ON and OFF pathways for Drosophila motion detection.
New
Impact
Desplan et al., New York City, United States. In Nature, 28 Sep 2014
We propose that Mi1 and Tm3 perform critical processing of the delayed and non-delayed input channels of the correlator responsible for the detection of light edges, while Tm1 and Tm2 play analogous roles in the detection of moving dark edges.
Targeting tropomyosin-receptor kinase fused gene in cancer.
Review
New
Tseng et al., Taipei, Taiwan. In Anticancer Res, Apr 2014
Tropomyosin-receptor kinase fused gene (TRK-fused gene, TFG) encodes a protein which is a conserved regulator of protein secretion that localizes in the endoplasmic reticulum exit sites and controls the export of materials from the endoplasmic reticulum.
TRPV1.
Review
New
Andersson et al., London, United Kingdom. In Handb Exp Pharmacol, Dec 2013
Structurally, TRPV1 subunits have six transmembrane (TM) domains with intracellular N- (containing 6 ankyrin-like repeats) and C-termini and a pore region between TM5 and TM6 containing sites that are important for channel activation and ion selectivity.
Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.
Review
New
Turnley et al., Melbourne, Australia. In Front Mol Neurosci, Dec 2013
They do this by binding to their cognate receptors, members of the Tropomyosin-related kinase (Trk) receptor tyrosine kinase family, namely TrkA, TrkB, and TrkC.
Structural basis for action by diverse antidepressants on biogenic amine transporters.
New
Impact
Gouaux et al., Portland, United States. In Nature, Dec 2013
The chemically diverse inhibitors have a remarkably similar mode of binding in which they straddle transmembrane helix (TM) 3, wedge between TM3/TM8 and TM1/TM6, and lock the transporter in a sodium- and chloride-bound outward-facing open conformation.
Nuclear tropomyosin and troponin in striated muscle: new roles in a new locale?
Review
New
Soto et al., Tallahassee, United States. In J Muscle Res Cell Motil, Aug 2013
Tropomyosin and troponin have well known Ca(2+)-regulatory functions in the striated muscle sarcomere.
Tropomyosin-receptor-kinases signaling in the nervous system.
Review
New
Purcaru et al., Craiova, Romania. In Maedica (buchar), Mar 2013
Tropomyosin-receptor-kinase receptor family controls synaptic strength and plasticity in the mammalian nervous system.
Identification and validation of novel serum markers for early diagnosis of endometriosis.
GeneRIF
Khole et al., Mumbai, India. In Hum Reprod, 2012
investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TPM3, stomatin-like protein 2, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified.
Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Impact
Kobilka et al., Stanford, United States. In Nature, 2011
The largest conformational changes in the β(2)AR include a 14 Å outward movement at the cytoplasmic end of transmembrane segment 6 (TM6) and an α-helical extension of the cytoplasmic end of TM5.
Structure and mechanism of the uracil transporter UraA.
Impact
Yan et al., Beijing, China. In Nature, 2011
A pair of antiparallel β-strands is located between TM3 and TM10 and has an important role in structural organization and substrate recognition.
Molecular diagnosis and targeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion.
GeneRIF
Tse et al., Xiamen, China. In Pediatr Blood Cancer, 2011
High TPM3-PDGFRB fusion protein expression is associated with chronic eosinophilic leukemia.
Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.
GeneRIF
Solaro et al., Chicago, United States. In J Muscle Res Cell Motil, 2011
The results identify a novel mode of myofilament desensitization to Ca(2+) associated with a DCM linked switch in TPM1-kappa.
Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments.
GeneRIF
Stehn et al., Westmead, Australia. In Exp Cell Res, 2011
variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations
Congenital fibre type disproportion associated with mutations in the tropomyosin 3 (TPM3) gene mimicking congenital myasthenia.
GeneRIF
Muntoni et al., London, United Kingdom. In Neuromuscul Disord, 2010
study reports clinico-pathological and electrophysiological features of 2 unrelated cases with heterozygous TPM3 mutation; cases highlight neuromuscular transmission defect in congenital myopathy with fibre type disproportion secondary to TPM3 mutations
Assembly of endogenous oskar mRNA particles for motor-dependent transport in the Drosophila oocyte.
Impact
Ephrussi et al., Heidelberg, Germany. In Cell, 2009
Our analysis uncovers a role for the EJC component Barentsz in recruiting Tropomyosin II (TmII) to oskar particles in the ooplasm and reveals that TmII is required for kinesin binding to the RNPs.
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