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Tropomyosin 3

TM3, Tropomyosin, TM5, TPM3
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Actin, ACID, HAD, Tropomyosin
Papers using TM3 antibodies
Oxidative stress-induced posttranslational modification of proteins as a target of functional food
Yoshikawa Toshikazu et al., In Journal of Clinical Biochemistry and Nutrition, 2008
... Tropomyosin-1 (TPM1) monoclonal antibody (D12H4, XP Rabbit) and Horseradish peroxidase (HRP)-linked anti-rabbit IgG were purchased from Cell Signaling (Beverly, MA) ...
Follicular cells acquire sertoli cell characteristics after oocyte loss
Tremblay Jacques J et al., In BMC Developmental Biology, 2004
... Total RNA from MA-10, mLTC-1, TM3 and R2C Leydig cell lines was extracted using the RNeasy Plus extraction kit (Qiagen, Mississauga, Ontario, Canada) and ...
Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy
Hardeman Edna C. et al., In The Journal of Cell Biology, 1984
... Generation of the Tropomyosin-3 (Tm3) transgenic mouse ...
Papers on TM3
Shellfish and House Dust Mite Allergies: Is the Link Tropomyosin?
Lee et al., Singapore, Singapore. In Allergy Asthma Immunol Res, Mar 2016
The major allergen in shellfish allergy is tropomyosin, a pan-allergen that is also found in house dust mites and cockroaches.
ALK-Rearranged Renal Cell Carcinomas in Children.
Perlman et al., Omaha, United States. In Genes Chromosomes Cancer, Feb 2016
Further investigation revealed ALK rearrangements in all cases, manifested molecularly by fusion transcripts of either VCL-ALK (3 patients all with sickle cell trait which had been previously reported) or TPM3-ALK (3 patients, none with sickle cell trait).
Limited dispersal in an ectoparasitic mite, Laelaps giganteus, contributes to significant phylogeographic congruence with their rodent hosts, Rhabdomys.
Matthee et al., Stellenbosch, South Africa. In Mol Ecol, Feb 2016
Analysis of the less variable nuclear intron Tropomyosin was in part consistent with these results.
Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices.
Sheetz et al., New York City, United States. In Nat Cell Biol, Jan 2016
When we removed actomyosin restriction by depleting tropomyosin 2.1, we observed larger steps and higher forces that resulted in aberrant rigidity sensing and growth of non-transformed cells on soft matrices.
Involvement of hypoxia-inducible factor-1α in the oxidative stress induced by advanced glycation end products in murine Leydig cells.
Sun et al., Chongqing, China. In Toxicol In Vitro, Jan 2016
The aim of the study was to investigate the role of HIF-1α in oxidative stress induced by AGEs in murine Leydig TM3 cells.
Comparative MD Simulations Indicate a Dual Role for Arg1323.50 in Dopamine-Dependent D2R Activation.
Gmeiner et al., Erlangen, Germany. In Plos One, Dec 2015
Residue Arg3.50 belongs to the highly conserved DRY-motif of class A GPCRs, which is located at the bottom of TM3.
Detection of lung adenocarcinoma with ROS1 rearrangement by IHC, FISH, and RT-PCR and analysis of its clinicopathologic features.
Zhou et al., Shanghai, China. In Onco Targets Ther, Dec 2015
The fusion patterns were CD74 e6-ROS1 e32, CD74 e6-ROS1 e34, and TPM3 e8-ROS1 e35, respectively.
Phylogenetic conservation of protein-lipid motifs in pentameric ligand-gated ion channels.
Barrantes, Buenos Aires, Argentina. In Biochim Biophys Acta, Sep 2015
The evolutionarily conserved design is manifested in: 1) the concentric three-ring architecture of the transmembrane region, 2) the occurrence in this region of distinct lipid consensus motifs in prokaryotic and eukaryotic pLGIC and 3) the key participation of the outer TM4 ring in conveying the influence of the lipid membrane environment to the middle TM1-TM3 ring and this, in turn, to the inner TM2 channel-lining ring, which determines the ion selectivity of the channel.
Propagation of conformational changes during μ-opioid receptor activation.
Granier et al., Montpellier, France. In Nature, Sep 2015
Our results show that conformational changes in transmembrane segments 5 and 6 (TM5 and TM6), which are required for the full engagement of a G protein, are almost completely dependent on the presence of both the agonist and the G protein mimetic nanobody, revealing a weak allosteric coupling between the agonist-binding pocket and the G-protein-coupling interface (TM5 and TM6), similar to that observed for the β2-adrenergic receptor.
Tropomyosin - master regulator of actin filament function in the cytoskeleton.
Mulvihill et al., Sydney, Australia. In J Cell Sci, Sep 2015
Tropomyosin (Tpm) isoforms are the master regulators of the functions of individual actin filaments in fungi and metazoans.
PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.
Yan et al., Beijing, China. In Science, Aug 2015
Each protomer comprises six transmembrane segments (TMs), with TM3 and TM4 contributing to homotrimerization.
Structure of the F-actin-tropomyosin complex.
Raunser et al., Dortmund, Germany. In Nature, Apr 2015
In striated muscle fibres, the binding of myosin motors to actin filaments is mainly regulated by tropomyosin and troponin.
Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
MacKinnon et al., New York City, United States. In Nature, 2015
Additional rotation of a membrane interacting TM2-TM3 segment, unique to mechanosensitive K2Ps, against TM4 may further stabilize the conductive conformation.
Tropomyosin as a Regulator of Actin Dynamics.
Khaitlina, Saint Petersburg, Russia. In Int Rev Cell Mol Biol, 2014
Tropomyosin is a major regulatory protein of contractile systems and cytoskeleton, an actin-binding protein that positions laterally along actin filaments and modulates actin-myosin interaction.
Expression of tropomyosin in relation to myofibrillogenesis in axolotl hearts.
Dube et al., Syracuse, United States. In Regen Med Res, 2013
Studies have shown a differential expression of tropomyosin between the conus and the ventricle indicating two different cardiac segments.
Identification and validation of novel serum markers for early diagnosis of endometriosis.
Khole et al., Mumbai, India. In Hum Reprod, 2012
investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TPM3, stomatin-like protein 2, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified.
Molecular diagnosis and targeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion.
Tse et al., Xiamen, China. In Pediatr Blood Cancer, 2011
High TPM3-PDGFRB fusion protein expression is associated with chronic eosinophilic leukemia.
Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.
Solaro et al., Chicago, United States. In J Muscle Res Cell Motil, 2011
The results identify a novel mode of myofilament desensitization to Ca(2+) associated with a DCM linked switch in TPM1-kappa.
Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments.
Stehn et al., Westmead, Australia. In Exp Cell Res, 2011
variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations
Congenital fibre type disproportion associated with mutations in the tropomyosin 3 (TPM3) gene mimicking congenital myasthenia.
Muntoni et al., London, United Kingdom. In Neuromuscul Disord, 2010
study reports clinico-pathological and electrophysiological features of 2 unrelated cases with heterozygous TPM3 mutation; cases highlight neuromuscular transmission defect in congenital myopathy with fibre type disproportion secondary to TPM3 mutations
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