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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Feb 2015.

Tropomyosin 3

TM3, Tropomyosin, TM5, TPM3
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Actin, ACID, HAD, Tropomyosin
Papers using TM3 antibodies
Oxidative stress-induced posttranslational modification of proteins as a target of functional food
Supplier
Yoshikawa Toshikazu et al., In Journal of Clinical Biochemistry and Nutrition, 2008
... Tropomyosin-1 (TPM1) monoclonal antibody (D12H4, XP Rabbit) and Horseradish peroxidase (HRP)-linked anti-rabbit IgG were purchased from Cell Signaling (Beverly, MA) ...
Follicular cells acquire sertoli cell characteristics after oocyte loss
Supplier
Tremblay Jacques J et al., In BMC Developmental Biology, 2004
... Total RNA from MA-10, mLTC-1, TM3 and R2C Leydig cell lines was extracted using the RNeasy Plus extraction kit (Qiagen, Mississauga, Ontario, Canada) and ...
Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy
Supplier
Hardeman Edna C. et al., In The Journal of Cell Biology, 1984
... Generation of the Tropomyosin-3 (Tm3) transgenic mouse ...
Papers on TM3
Cysteine Substitution of Transmembrane Domain Amino Acids Alters the Ethanol Inhibition of GluN1/GluN2A N-Methyl-d-Aspartate Receptors.
New
Woodward et al., Charleston, United States. In J Pharmacol Exp Ther, 30 Apr 2015
N-Methyl-d-aspartate receptors (NMDARs) are inhibited by behaviorally relevant concentrations of ethanol, and residues within transmembrane (TM) domains of NMDARs, including TM3 GluN1 phenylalanine 639 (F639), regulate this sensitivity.
Identification of cholesterol gallstone with two-dimensional gel electrophoresis and mass spectrometry.
New
Liu et al., Shanghai, China. In Ann Hepatol, 31 Mar 2015
Total 19 protein spots were found to be different between two groups and 11 proteins were identified, among which 4 ones (such as Peroxiredoxin 3/Prdx3) were down-regulated and 7 (such as Tropomyosin 4/TPM4, Transgelin/SM22, Transthyretin/ TTR) were up-regulated in gallstone group.
Phylogenomics reveals surprising sets of essential and dispensable clades of MIKC(c) -group MADS-box genes in flowering plants.
New
Theißen et al., Jena, Germany. In J Exp Zool B Mol Dev Evol, 11 Mar 2015
The clades of MIKC(C) -group genes that have never been wiped out in any of the investigated species comprises, in addition to the expected floral organ identity genes, also TM3-like (SOC1-like), StMADS11-like (SVP-like), AGL17-like and GGM13-like (Bsister ) genes, suggesting that these genes are more important for angiosperm development and evolution than has previously been appreciated.
Structural characterization of triple transmembrane domain containing fragments of a yeast G protein-coupled receptor in an organic : aqueous environment by solution-state NMR spectroscopy.
New
Naider et al., New York City, United States. In J Pept Sci, 02 Mar 2015
The 131-residue polypeptide Ste2p(G31-R161), TM1-TM3, was investigated by solution NMR in trifluoroethanol/water.
TRKing Down an Old Oncogene in a New Era of Targeted Therapy.
Review
New
Doebele et al., Aurora, United States. In Cancer Discov, 19 Jan 2015
These recent developments have led us to revisit an old oncogene, Trk (originally identified as OncD), which encodes the TPM3-NTRK1 gene fusion and was one of the first transforming chromosomal rearrangements identified 32 years ago.
Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
New
Impact
MacKinnon et al., New York City, United States. In Nature, 04 Jan 2015
Additional rotation of a membrane interacting TM2-TM3 segment, unique to mechanosensitive K2Ps, against TM4 may further stabilize the conductive conformation.
Structure of the F-actin--tropomyosin complex.
New
Impact
Raunser et al., Dortmund, Germany. In Nature, Jan 2015
In striated muscle fibres, the binding of myosin motors to actin filaments is mainly regulated by tropomyosin and troponin.
Anchored multiplex PCR for targeted next-generation sequencing.
New
Impact
Le et al., Boston, United States. In Nat Med, Dec 2014
On the basis of our experience with performing AMP on 986 clinical FFPE samples, we show its potential as both a robust clinical assay and a powerful discovery tool, which we used to identify new therapeutically important gene fusions: ARHGEF2-NTRK1 and CHTOP-NTRK1 in glioblastoma, MSN-ROS1, TRIM4-BRAF, VAMP2-NRG1, TPM3-NTRK1 and RUFY2-RET in lung cancer, FGFR2-CREB5 in cholangiocarcinoma and PPL-NTRK1 in thyroid carcinoma.
Label-free quantitative mass spectrometry reveals a panel of differentially expressed proteins in colorectal cancer.
New
Gao et al., Luoyang, China. In Biomed Res Int, Dec 2014
Among the differentially expressed proteins, tropomyosin-3 (TPM3), endoplasmic reticulum resident protein 29 (ERp29), 18 kDa cationic antimicrobial protein (CAMP), and heat shock 70 kDa protein 8 (HSPA8) were verified to be upregulated in CRC tissue and seven cell lines through western blot analysis.
Processing properties of ON and OFF pathways for Drosophila motion detection.
New
Impact
Desplan et al., New York City, United States. In Nature, Sep 2014
We propose that Mi1 and Tm3 perform critical processing of the delayed and non-delayed input channels of the correlator responsible for the detection of light edges, while Tm1 and Tm2 play analogous roles in the detection of moving dark edges.
Tropomyosin receptor kinase inhibitors: a patent update 2009 - 2013.
Review
New
Walker et al., Abingdon, United Kingdom. In Expert Opin Ther Pat, Jul 2014
Scifinder and Google were used to find relevant patents and clinical information using Trk or Tropomyosin as the search term.
Targeting tropomyosin-receptor kinase fused gene in cancer.
Review
New
Tseng et al., Taipei, Taiwan. In Anticancer Res, Apr 2014
Tropomyosin-receptor kinase fused gene (TRK-fused gene, TFG) encodes a protein which is a conserved regulator of protein secretion that localizes in the endoplasmic reticulum exit sites and controls the export of materials from the endoplasmic reticulum.
Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.
Review
Turnley et al., Melbourne, Australia. In Front Mol Neurosci, 2013
They do this by binding to their cognate receptors, members of the Tropomyosin-related kinase (Trk) receptor tyrosine kinase family, namely TrkA, TrkB, and TrkC.
TRPV1.
Review
Andersson et al., London, United Kingdom. In Handb Exp Pharmacol, 2013
Structurally, TRPV1 subunits have six transmembrane (TM) domains with intracellular N- (containing 6 ankyrin-like repeats) and C-termini and a pore region between TM5 and TM6 containing sites that are important for channel activation and ion selectivity.
Structural basis for action by diverse antidepressants on biogenic amine transporters.
Impact
Gouaux et al., Portland, United States. In Nature, 2013
The chemically diverse inhibitors have a remarkably similar mode of binding in which they straddle transmembrane helix (TM) 3, wedge between TM3/TM8 and TM1/TM6, and lock the transporter in a sodium- and chloride-bound outward-facing open conformation.
Identification and validation of novel serum markers for early diagnosis of endometriosis.
GeneRIF
Khole et al., Mumbai, India. In Hum Reprod, 2012
investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TPM3, stomatin-like protein 2, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified.
Molecular diagnosis and targeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion.
GeneRIF
Tse et al., Xiamen, China. In Pediatr Blood Cancer, 2011
High TPM3-PDGFRB fusion protein expression is associated with chronic eosinophilic leukemia.
Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.
GeneRIF
Solaro et al., Chicago, United States. In J Muscle Res Cell Motil, 2011
The results identify a novel mode of myofilament desensitization to Ca(2+) associated with a DCM linked switch in TPM1-kappa.
Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments.
GeneRIF
Stehn et al., Westmead, Australia. In Exp Cell Res, 2011
variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations
Congenital fibre type disproportion associated with mutations in the tropomyosin 3 (TPM3) gene mimicking congenital myasthenia.
GeneRIF
Muntoni et al., London, United Kingdom. In Neuromuscul Disord, 2010
study reports clinico-pathological and electrophysiological features of 2 unrelated cases with heterozygous TPM3 mutation; cases highlight neuromuscular transmission defect in congenital myopathy with fibre type disproportion secondary to TPM3 mutations
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