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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Toll-like receptor 9

TLR9, Toll-Like Receptor 9
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TLR4, TLR2, TLR7, CAN, V1a
Papers using TLR9 antibodies
Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome.
Supplier
Ratner Adam J., In PLoS ONE, 1999
... Anti-human TLR4 and TLR9 antibodies were obtained from Imgenex (San Diego, CA) ...
Papers on TLR9
Self-reactive IgE exacerbates interferon responses associated with autoimmunity.
New
Impact
Sanjuan et al., Gaithersburg, United States. In Nat Immunol, Feb 2016
The concentration of dsDNA-specific IgE found in patient serum correlated with disease severity and greatly potentiated pDC function by triggering phagocytosis via the high-affinity FcɛRI receptor for IgE, followed by Toll-like receptor 9 (TLR9)-mediated sensing of DNA in phagosomes.
Telomeric G-quadruplex-forming DNA fragments induce TLR9-mediated and LL-37-regulated invasion in breast cancer cells in vitro.
New
Selander et al., Birmingham, United States. In Breast Cancer Res Treat, Feb 2016
UNASSIGNED: Toll-like receptor 9 (TLR9) is a cellular DNA-receptor widely expressed in cancers.
Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress.
New
Tsung et al., Pittsburgh, United States. In Cancer Res, Feb 2016
Mechanistic investigations in vitro indicated that mouse neutrophil-derived NET triggered HMGB1 release and activated TLR9-dependent pathways in cancer cells to promote their adhesion, proliferation, migration and invasion.
Association between toll-like receptor polymorphisms and systemic lupus erythematosus: a meta-analysis update.
New
Song et al., Seoul, South Korea. In Lupus, Feb 2016
The meta-analysis showed no association between the two alleles of the rs352140, rs5743836, and rs352139 polymorphisms of TLR9 and SLE, but indicated an association between the two alleles of the rs187084 polymorphism (TLR9) and SLE in the overall population (OR = 0.869, 95% CI = 0.762-0.992,
Endosomal Toll-like receptors in clinically overt and silent autoimmunity.
Review
New
Buyon et al., New York City, United States. In Immunol Rev, Jan 2016
TLR7 and TLR9 function as innate sensors of viral infection as their ligands are ssRNA and dsDNA, respectively.
Age-associated B cells: key mediators of both protective and autoreactive humoral responses.
Review
New
Cancro et al., Philadelphia, United States. In Immunol Rev, Jan 2016
These cells are characterized by a T-BET driven transcriptional program, robust responsiveness to TLR7 and TLR9 ligands, and a propensity for IgG2a/c production.
Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition.
New
Impact
Lai et al., Kunming, China. In Immunity, Jan 2016
The complex was resistant to DNase II degradation and escaped from autophagic recognition, leading to activation of Toll-like receptor 9 (TLR9)-mediated inflammatory responses.
Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection.
New
Impact
Sigal et al., Philadelphia, United States. In Immunity, Jan 2016
Toll-like receptor 9 (TLR9), its adaptor MyD88, the downstream transcription factor interferon regulatory factor 7 (IRF7), and type I interferons (IFN-I) are all required for resistance to infection with ectromelia virus (ECTV).
Overexpression of TLR2 and TLR9 on monocyte subsets of active rheumatoid arthritis patients contributes to enhance responsiveness to TLR agonists.
New
Gosselin et al., Québec, Canada. In Arthritis Res Ther, Dec 2015
We assessed the expression levels of TLR2 and TLR9 in monocyte subsets of active RA patients and characterized their cytokine profiles in response to synthetic and viral TLR2 and TLR9 agonists, including Epstein-Barr virus (EBV) which is suspected to contribute to RA symptoms.
The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways.
New
Salzet et al., Lille, France. In Sci Rep, Dec 2015
Endosomal TLR9 is considered as a potent anti-tumoral therapeutic target.
Effects of Sequence Variations in Innate Immune Response Genes on Infectious Outcome in Trauma Patients: A Comprehensive Review.
Review
New
Van Lieshout et al., Rotterdam, Netherlands. In Shock, Nov 2015
The following genes have been studied in populations of trauma patients: CD14, HMGB1, IFNG, IL1A, IL1B, IL1RN, IL4, IL6, IL8, IL10, IL17F, IL18, MBL2, MASP2, FCN2, TLR1, TLR2, TLR4, TLR9, TNF, LTA, GR, MYLK, NLRP3, PRDX6, RAGE, HSPA1B, HSPA1L, HSP90, SERPINE1, IRAK1, IRAK3, VEGFA, LY96, ANGPT2, LBP, MicroRNA, and mtDNA.
Liquid-crystalline ordering of antimicrobial peptide-DNA complexes controls TLR9 activation.
New
Impact
Wong et al., Los Angeles, United States. In Nat Mater, Jul 2015
Double-stranded DNA (dsDNA) can trigger the production of type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by binding to endosomal Toll-like receptor-9 (TLR9; refs 1-5).
Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.
New
Impact
Shimizu et al., Tokyo, Japan. In Nature, May 2015
TLR9 recognizes bacterial and viral DNA containing the cytosine-phosphate-guanine (CpG) dideoxynucleotide motif.
Synthetic self-adjuvanting glycopeptide cancer vaccines.
Review
Payne et al., Sydney, Australia. In Front Chem, 2014
The adjuvants used in these vaccines predominantly include lipopeptide- or lipoamino acid-based TLR2 agonists, although studies investigating stimulation of TLR9 and TLR4 are also discussed.
Hepatitis B Virus-Related Hepatocellular Carcinoma: Pathogenic Mechanisms and Novel Therapeutic Interventions.
Review
Ren et al., Xiamen, China. In Gastrointest Tumors, 2014
Stimulation of the Toll-like receptors (TLRs), particularly TLR9, provides another means of boosting the antiviral response.
Leucine-rich repeat 11 of Toll-like receptor 9 can tightly bind to CpG-containing oligodeoxynucleotides, and the positively charged residues are critical for the high affinity.
GeneRIF
Zhou et al., Chongqing, China. In J Biol Chem, 2012
Leucine-rich repeat 11 of Toll-like receptor 9 can tightly bind to CpG-containing oligodeoxynucleotides, and the positively charged residues are critical for the high affinity.
T granules in human platelets function in TLR9 organization and signaling.
GeneRIF
Italiano et al., Boston, United States. In J Cell Biol, 2012
The TLR9 transcript is specifically up-regulated during pro-platelet (PLT)production and is distributed to a novel electron-dense tubular system-related PLT cell compartment.
Involvement of Toll-like Receptor 9 polymorphism in cervical cancer development.
GeneRIF
Jagodziński et al., Poznań, Poland. In Mol Biol Rep, 2012
Our studies suggest that the TLR9 -1486 T/C and C2848T polymorphisms may be a genetic risk factor for cervical cancer.
HHV-6B induces IFN-lambda1 responses in cord plasmacytoid dendritic cells through TLR9.
GeneRIF
Eriksson et al., Göteborg, Sweden. In Plos One, 2011
Inactivated HHV-6B is a strong inducer of IFN-lambda1 in plasmacytoid dendritic cells and this induction is TLR9-dependent.
DNase Sda1 allows invasive M1T1 Group A Streptococcus to prevent TLR9-dependent recognition.
GeneRIF
Zinkernagel et al., Zürich, Switzerland. In Plos Pathog, 2011
Group A Streptococcus Sda1 suppressed both the TLR9-mediated innate immune response and macrophage bactericidal activity
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