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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Toll-like receptor 8

TLR8, Toll-Like Receptor 8
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TLR7, TLR3, TLR9, TLR4, TLR2
Papers using TLR8 antibodies
Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
Supplier
Gay Nick, In PLoS ONE, 2009
... Canada), anti-p115 pAb (Calbiochem, Darmstadt, Germany), anti-LAMP-1 mAb (Biolegend), anti-MPR pAb (Abcam, Cambridge, UK), anti-human TLR8 mAb (Dendritics, LYON, France) and anti-human ...
Papers on TLR8
Association between toll-like receptor polymorphisms and systemic lupus erythematosus: a meta-analysis update.
New
Song et al., Seoul, South Korea. In Lupus, Feb 2016
No association was detected between rs3764880 (TLR8) and SLE; however, our meta-analysis indicated an association between rs3764879 (TLR8) and SLE in Caucasians (OR = 1.414, 95% CI = 1.139-1.756,
Microbial Nucleic Acid Sensing in Oral and Systemic Diseases.
Review
New
Sahingur et al., Richmond, United States. In J Dent Res, Jan 2016
The discovery of innate immune activation through nucleic acid recognition by intracellular PRRs such as endosomal TLRs (TLR3, TLR7, TLR8, and TLR9) and cytoplasmic proteins (absent in melanoma 2 and DNA-dependent activator of interferon regulatory factor) opened a new paradigm: Nucleic acid sensing is now implicated in multiple immune and inflammatory conditions (e.g., atherosclerosis, cancer), viral (e.g., human papillomavirus, herpes virus) and bacterial (e.g., Helicobacter pylori, pneumonia) diseases, and autoimmune disorders (e.g., systemic lupus erythematosus, rheumatoid arthritis).
Evidence for adaptation of porcine Toll-like receptors.
New
Schook et al., Champaign, United States. In Immunogenetics, Jan 2016
The genomic sequence encoding the ectodomain, responsible for interacting with pathogen ligands of bacterial (TLR1, TLR2 and TLR6) and viral (TLR3, TLR7 and TLR8) receptors, was obtained.
Toll-like receptor 4 ligands down-regulate FcγRIIb via MARCH3-mediated ubiquitination.
New
Butchar et al., United States. In J Biol Chem, Jan 2016
Here, we screened a panel of Toll-like receptor (TLR) agonists and found that those selective for TLR4 and TLR8 could significantly down-regulate the expression of FcγRIIb.
Genotypic distribution of common variants of endosomal toll like receptors in healthy Spanish women. A comparative study with other populations.
New
Citores et al., Majadahonda, Spain. In Gene, Jan 2016
Nine substitutions were analysed in 150 DNA samples from 150 Spanish, non-related healthy females: TLR3 rs3775291 and rs5743305; TLR7 rs179008 and rs5743781; TLR8 rs3764880 and TLR9 rs187084, rs5743836, rs352139 and rs352140.
Gene Polymorphism of Toll-Like Receptors and Lung Function at Five to Seven Years of Age after Infant Bronchiolitis.
New
Korppi et al., Tampere, Finland. In Plos One, Dec 2015
Data on single nucleotide polymorphisms (SNP) of TLR1 rs5743618, TLR2 rs5743708, TLR6 rs5743810 and TLR10 rs4129009 (TLR2 subfamily) and TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992 and TLR 9 rs187084 were available for analyses.
Role of innate immune system in systemic sclerosis.
Review
New
O'Reilly et al., Durham, United Kingdom. In Semin Immunopathol, Sep 2015
Further, stimulation of TLR8 with single-stranded RNA leads to increased expression of TIMP-1.
Comparative Geometrical Analysis of Leucine-Rich Repeat Structures in the Nod-Like and Toll-Like Receptors in Vertebrate Innate Immunity.
Review
Kretsinger et al., Sapporo, Japan. In Biomolecules, 2014
The structures of the LRR domains of NLRC4, NLRP1, and NLRX1 in NLRs and of TLR1-5, TLR6, TLR8, TLR9 in TLRs have been determined.
Toll-like receptors in Alzheimer's disease: a therapeutic perspective.
Review
Bramanti et al., Messina, Italy. In Cns Neurol Disord Drug Targets, 2013
Similarly, TLR7, TLR8 and TLR9 can enhance microglial Aβ uptake in the early stage, but over time they contribute to neuroinflammation.
Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.
Impact
Shimizu et al., Tokyo, Japan. In Science, 2013
Toll-like receptor 7 (TLR7) and TLR8 recognize single-stranded RNA and initiate innate immune responses.
Epigenetic regulation of tumor necrosis factor α (TNFα) release in human macrophages by HIV-1 single-stranded RNA (ssRNA) is dependent on TLR8 signaling.
GeneRIF
Tachado et al., Boston, United States. In J Biol Chem, 2012
Epigenetic regulation of tumor necrosis factor alpha (TNFalpha) release in human macrophages by HIV-1 single-stranded RNA (ssRNA) is dependent on TLR8 signaling
[Toll-like receptor 8: the awkward TLR].
GeneRIF
Demaria et al., Marseille, France. In Med Sci (paris), 2012
TLR8 plays an important role in the regulation of TLR7-mediated autoimmunity in the mouse. Review.
R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes.
GeneRIF
Shang et al., Shenyang, China. In Bmc Infect Dis, 2011
The study provides evidence that the TLR7 and TLR8 triggering can suppress HIV replication in monocytes and lead to postpone HIV disease progression.
A comparative study of human TLR 7/8 stimulatory trimer compositions in influenza A viral genomes.
GeneRIF
Chen et al., Taipei, Taiwan. In Plos One, 2011
Segments 1, 2, 3 and 4 may be major determinants of the stimulatory activity exerted on human TLRs 7 and 8.
Quantitative imaging of lineage-specific Toll-like receptor-mediated signaling in monocytes and dendritic cells from small samples of human blood.
GeneRIF
Montgomery et al., United States. In J Vis Exp, 2011
Authors demonstrate the use of ImageStream in DCs to assess TLR7/8 activation-mediated increases in phosphorylation and nuclear translocation of a key transcription factor.
Toll-like receptors play a crucial part in the pathophysiological activity of antiphospholipid antibodies.
Review
von Landenberg, Mainz, Germany. In Auto Immun Highlights, 2011
The investigation of some of those mechanisms in more detail enlightens the involvement of the intracellular receptors TLR7 and TLR8 in a central point.
Expression of therapeutic proteins after delivery of chemically modified mRNA in mice.
Impact
Rudolph et al., München, Germany. In Nat Biotechnol, 2011
A combination of nucleotide modifications abrogates mRNA interaction with Toll-like receptor (TLR)3, TLR7, TLR8 and retinoid-inducible gene I (RIG-I), resulting in low immunogenicity and higher stability in mice.
Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors.
Impact
GeneRIF
Geissmann et al., Paris, France. In Immunity, 2010
Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors.
HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells.
Impact
GeneRIF
Geijtenbeek et al., Amsterdam, Netherlands. In Nat Immunol, 2010
exploited by in HIV-1virus for productive infection of dendritic cells
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
Impact
Hornung et al., Bonn, Germany. In Nat Immunol, 2009
RNA is sensed by Toll-like receptor 7 (TLR7) and TLR8 or by the RNA helicases LGP2, Mda5 and RIG-I to trigger antiviral responses.
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