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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Toll-like receptor 7

TLR7, Toll-Like Receptor 7
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TLR9, TLR3, CAN, TLR4, TLR8
Papers using TLR7 antibodies
Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells.
Darlix Jean-Luc E. P. H., In PLoS ONE, 2006
... The plasmids for TLR3 and TLR7 (pUNO-hTLR3-HA and pUNO-hTLR7-HA) were purchased from Invivogen (San Diego, CA) and the siRNAs targeting those genes were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on TLR7
S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells.
Weigert et al., Frankfurt am Main, Germany. In J Immunol, Feb 2016
UNASSIGNED: Plasmacytoid dendritic cells (pDCs) produce large amounts of type I IFN in response to TLR7/9 ligands.
C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus.
Botto et al., London, United Kingdom. In J Immunol, Feb 2016
Intraperitoneal injection of pristane induces a lupus-like syndrome whose pathogenesis implicates the secretion of type I IFN by CD11b(+) Ly6C(high) inflammatory monocytes in a TLR7-dependent fashion.
Age-associated B cells: key mediators of both protective and autoreactive humoral responses.
Cancro et al., Philadelphia, United States. In Immunol Rev, Jan 2016
These cells are characterized by a T-BET driven transcriptional program, robust responsiveness to TLR7 and TLR9 ligands, and a propensity for IgG2a/c production.
Endosomal Toll-like receptors in clinically overt and silent autoimmunity.
Buyon et al., New York City, United States. In Immunol Rev, Jan 2016
TLR7 and TLR9 function as innate sensors of viral infection as their ligands are ssRNA and dsDNA, respectively.
Human Milk Components Modulate Toll-Like Receptor-Mediated Inflammation.
Newburg et al., Boston, United States. In Adv Nutr, Jan 2016
Human milk on the whole is strongly anti-inflammatory, and contains abundant components that depress TLR signaling pathways: sTLR2 and sCD14 inhibit TLR2 signaling; sCD14, lactadherin, lactoferrin, and 2'-fucosyllactose attenuate TLR4 signaling; 3'-galactosyllactose inhibits TLR3 signaling, and β-defensin 2 inhibits TLR7 signaling.
Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line.
Shieh et al., Taiwan. In J Dermatol Sci, Jan 2016
Using BCC/KMC1 cell line as a model, the upstream signaling of p53 activation was dissected by over-expression of TLR7/8, the addition of ROS scavenger, ATM/ATR inhibitors and pan-caspase inhibitor.
Toll-like receptors: potential targets for lupus treatment.
Zuo et al., Shanghai, China. In Acta Pharmacol Sin, Dec 2015
Genome-wide association studies, experimental mouse models and clinical sample studies have provided evidence for the involvement of TLRs, including TLR2/4, TLR5, TLR3 and TLR7/8/9, in SLE pathogenesis.
Molecular Determinants of GS-9620-Dependent TLR7 Activation.
Pflanz et al., Foster City, United States. In Plos One, Dec 2015
However, the molecular determinants of GS-9620-dependent activation of TLR7 are not well defined.
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity.
Seder et al., Bethesda, United States. In Nat Biotechnol, Nov 2015
Here, we attached small molecule TLR-7/8a to polymer scaffolds (polymer-TLR-7/8a) and evaluated how different physicochemical properties of the TLR-7/8a and polymer carrier influenced the location, magnitude and duration of innate immune activation in vivo.
Behçet's syndrome: a critical digest of the 2014-2015 literature.
Hamuryudan et al., İstanbul, Turkey. In Clin Exp Rheumatol, Nov 2015
Innate immunity was explored and TLR7 copy number variations and nucleic acid sensors of varying inflammasome pathways were studied.
OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.
Blanco et al., Bordeaux, France. In Immunity, Jul 2015
Immune complexes containing RNA induced OX40L expression on myeloid APCs via TLR7 activation.
The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.
Means et al., United States. In Nat Immunol, May 2015
The molecules and pathways that fine-tune innate inflammatory responses mediated by Toll-like receptor 7 (TLR7) remain to be fully elucidated.
TLR7 induces anergy in human CD4(+) T cells.
Hafler et al., New Haven, United States. In Nat Immunol, 2015
Here we found that engagement of TLR7 in CD4(+) T cells induced intracellular calcium flux with activation of an anergic gene-expression program dependent on the transcription factor NFATc2, as well as unresponsiveness of T cells.
Synergistic Stimulation with Different TLR7 Ligands Modulates Gene Expression Patterns in the Human Plasmacytoid Dendritic Cell Line CAL-1.
Klaschik et al., Bonn, Germany. In Mediators Inflamm, 2014
TLR7 ligation in plasmacytoid dendritic cells is promising for the treatment of cancer, allergy, and infectious diseases; however, high doses of ligands are required.
The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.
Toyama-Sorimachi et al., Tokyo, Japan. In Immunity, 2014
SLC15A4 is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of certain diseases including lupus-like autoimmunity.
Selective activation of Toll-like receptor 7 in activated hepatic stellate cells may modulate their profibrogenic phenotype.
Chuang et al., Kao-hsiung, Taiwan. In Biochem J, 2012
obstructive jaundice is associated with down-regulation of TLR7 and up-regulation of profibrogenic gene expression in hepatic stellate cells
Toll-like receptor 7 protects from atherosclerosis by constraining "inflammatory" macrophage activation.
Andreakos et al., Athens, Greece. In Circulation, 2012
TLR7, a receptor recognizing self-nucleic acid complexes, is protective in atherosclerosis.
Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms.
Bishop et al., Iowa City, United States. In J Immunol, 2012
These new findings reveal distinct and overlapping signaling mechanisms used by B-cell antigen receptor and IFNAR in the regulation of TLR7 tolerance and activation.
Extracellularly delivered single-stranded viral RNA causes neurodegeneration dependent on TLR7.
Lehnardt et al., Berlin, Germany. In J Immunol, 2012
TLR7 is activated in neurons through which extracellularly delivered single-stranded HIV viral RNA contributes to central nervous system damage, determining an obligatory role for TLR7 in this signaling pathway.
Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.
Oldstone et al., Los Angeles, United States. In Cell Host Microbe, 2012
Study shows that TLR7 signaling dictates either clearance or establishment of life-long chronic infection by lymphocytic choriomeningitis virus (LCMV) Cl 13 but does not affect clearance of the acute LCMV Armstrong 53b strain.
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