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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Toll-like receptor 6

TLR6, Toll-Like Receptor 6
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: TLR2, Toll-like receptor, TLR4, TLR9, TLR3
Papers on TLR6
Differential activation of innate immune pathways by distinct islet amyloid polypeptide (IAPP) aggregates.
New
Verchere et al., Canada. In J Biol Chem, Feb 2016
Blockade of TLR6 but not TLR1 prevented hIAPP-induced TLR2 activation, consistent with stimulation of a TLR2/6 heterodimer.
Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors.
New
Kelso et al., Leipzig, Germany. In Am J Hum Genet, Feb 2016
Here we document a cluster of three Toll-like receptors (TLR6-TLR1-TLR10) in modern humans that carries three distinct archaic haplotypes, indicating repeated introgression from archaic humans.
Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.
New
Quintana-Murci et al., Paris, France. In Am J Hum Genet, Feb 2016
Notably, among the genes presenting the highest Neandertal ancestry, we find the TLR6-TLR1-TLR10 cluster, which also contains functional adaptive variation in Europeans.
Toll-like Receptor Expression Profile of Human Dental Pulp Stem/Progenitor Cells.
New
Dörfer et al., Kiel, Germany. In J Endod, Feb 2016
The inflammatory medium upregulated the expression of TLRs 2, 3, 4, 5, and 8, downregulated TLRs 1, 7, 9, and 10, and abolished TLR6.
Saturated fatty acids trigger TLR4-mediated inflammatory response.
Review
New
Hermsdorff et al., Viçosa, Brazil. In Atherosclerosis, Jan 2016
(3) In addition, this metabolic endotoxemia leads to an oxidative stress thereby producing atherogenic lipids - oxLDL and oxidized phospholipids - which trigger CD36-TLR4-TLR6 inflammatory response.
Immunomodulatory effect of riboflavin deficiency and enrichment - reversible pathological response versus silencing of inflammatory activation.
New
Plytycz3 et al., Kraków, Poland. In J Physiol Pharmacol, Dec 2015
Moreover, the TLR6, NO, iNOS, IL-1β, MCP-1, and the keratinocyte chemoattractant (KC) levels significantly decreased in the zymosan-stimulated groups maintained in riboflavin-enriched medium.
Update on the pathogenesis and treatment of the antiphospholipid syndrome.
Review
New
Meroni et al., Milano, Italy. In Curr Opin Rheumatol, Sep 2015
AnnexinA2 and toll-like receptor (TLR)4 have been identified as the main receptors for β2GPI/anti-β2GPI antibodies on target cells; additional co-receptors might include TLR1, TLR2 and TLR6.
Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility.
Review
New
Arshad et al., Islamabad, Pakistan. In Immunol Res, Jun 2015
TLR2 makes heterodimer with TLR1 or TLR6 and recognizes a wide variety of microbial ligands.
TLR1, 2, 4, 6 and 9 Variants Associated with Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis.
Review
Salie et al., Stellenbosch, South Africa. In Plos One, 2014
The T allele of TLR6 rs5743810 conferred protection across all ethnic groups.
Comparative Geometrical Analysis of Leucine-Rich Repeat Structures in the Nod-Like and Toll-Like Receptors in Vertebrate Innate Immunity.
Review
Kretsinger et al., Sapporo, Japan. In Biomolecules, 2014
The structures of the LRR domains of NLRC4, NLRP1, and NLRX1 in NLRs and of TLR1-5, TLR6, TLR8, TLR9 in TLRs have been determined.
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
Impact
EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium et al., Copenhagen, Denmark. In Nat Genet, 2013
We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B.
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
Impact
Tung et al., Mountain View, United States. In Nat Genet, 2013
We identified 16 shared susceptibility loci with association P<5×10(-8), including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P=5.3×10(-21)); 6p21.33 near HLA-C and MICA (rs9266772, P=3.2×10(-12)); 5p13.1 near PTGER4 (rs7720838, P=8.2×10(-11)); 2q33.1 in PLCL1 (rs10497813, P=6.1×10(-10)), 3q28 in LPP (rs9860547, P=1.2×10(-9)); 20q13.2 in NFATC2 (rs6021270, P=6.9×10(-9)), 4q27 in ADAD1 (rs17388568, P=3.9×10(-8)); and 14q21.1 near FOXA1 and TTC6 (rs1998359, P=4.8×10(-8)).
Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.
GeneRIF
Turpeinen et al., Helsinki, Finland. In Scand J Immunol, 2012
The results showed that the genetic markers in TLR1, TLR4, TLR5 TLR6, and TLR10 were associated with the occurrence of acute Graft-versus-host disease following hematopoietic stem cell transplantation
Polymorphisms in the TLR6 gene associated with the inverse association between childhood acute lymphoblastic leukemia and atopic disease.
GeneRIF
Koppelman et al., Groningen, Netherlands. In Leukemia, 2012
Single nucleotide polymorphisms in TLR6 gene is associated with the inverse association between childhood acute lymphoblastic leukemia and atopic disease.
Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.
GeneRIF
Bochud et al., Lausanne, Switzerland. In J Infect Dis, 2012
Innate immune detection of Aspergillus fumigatus is mediated by TLR4 and TLR2 together with TLR1 or TLR6 in mice.
Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.
GeneRIF
Grutters et al., Nieuwegein, Netherlands. In Tissue Antigens, 2012
absence of the common haplotype in the TLR10-TLR1-TLR6 gene cluster increases the risk of developing chronic disease in patients already affected by sarcoidosis.
Association between toll-like receptors/CD14 gene polymorphisms and inflammatory bowel disease in Korean population.
GeneRIF
Choi et al., Suwŏn, South Korea. In J Korean Med Sci, 2012
No TLR6 polymorphisms were detected in Korean subjects.
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
Impact
GeneRIF
Moore et al., Boston, United States. In Nat Immunol, 2010
Our results identify CD36-TLR4-TLR6 activation as a common molecular mechanism by which atherogenic lipids and amyloid-beta stimulate sterile inflammation
TLR2 looks at lipoproteins.
Impact
Modlin et al., Los Angeles, United States. In Immunity, 2010
In this issue of Immunity, Kang et al. (2009) provide insight into the mechanisms by which TLR2-TLR6 heterodimers recognize diacylated liporoteins, whereas TLR2-TLR1 heterodimers recognize triacylated lipopeptides.
Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.
Impact
Lee et al., Taejŏn, South Korea. In Immunity, 2010
Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6.
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