Toll-like receptors: potential targets for lupus treatment.
Shanghai, China. In Acta Pharmacol Sin, Dec 2015
Genome-wide association studies, experimental mouse models and clinical sample studies have provided evidence for the involvement of TLRs, including TLR2/4, TLR5, TLR3 and TLR7/8/9, in SLE pathogenesis.
Common TLR5 mutations control cancer progression.
Boston, United States. In Cancer Cell, Feb 2015
In this issue of Cancer Cell, Rutkowski and colleagues indicate that TLR5 signaling deficiency, which occurs in ∼10% of the population, changes interactions with commensal microbiota and deregulates a cascade of inflammatory events that can suppress or accelerate extraintestinal cancers.