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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Toll-like receptor 4

TLR4, Toll-Like Receptor 4
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: V1a, Interleukin-6, TLR2, CAN, MyD88
Papers using TLR4 antibodies
Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92
Supplier
Jacobs Roland, In PLoS ONE, 2010
... The phycoerythrin (PE)-conjugated mouse anti-human perforin (dG9) mAb, the allophycocyanin (APC)-conjugated mouse anti-human TLR-4 mAb and the MCP-1 commercial ELISA kit were obtained from eBioscience (Hatfield, UK) ...
YK-4-279 Inhibits ERG and ETV1 Mediated Prostate Cancer Cell Invasion.
Supplier
Li Jun, In PLoS ONE, 2010
... The rabbit polyclonal antibody to TLR4, clone H-80, was purchased from Santa Cruz Biotechnology, Inc ...
The immunoglobulin E-toll-like receptor network
Supplier
Brzezińska-Błaszczyk Ewa et al., In Mediators of Inflammation, 2008
... antibodies, rabbit IgG isotype control, phycoerythrin (PE)-conjugated donkey anti-rabbit IgG F(ab′)2 fragments, PE-conjugated mouse anti-rat TLR4 IgG antibodies, and PE-conjugates mouse IgG isotype control were obtained from Abcam Inc ...
Seasonal changes in mood and behavior are linked to metabolic syndrome.
Supplier
Lu Xin-Yun, In PLoS ONE, 2007
... polyclonal, sc-12882), phospho-IKK (pIKK) (rabbit polyclonal, sc-23470), POMC (rabbit polyclonal, sc-20148), AgRP (rabbit polyclonal, sc-18634), TLR4 (rabbit polyclonal, sc-13591), F4/80 (rabbit polyclonal, sc-25830), and FITC or rodhamin conjugated goat and rabbit antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Cellular localization and trafficking of tissue factor
Supplier
Kaushal Deepak, In PLoS ONE, 2005
... TLR2 and TLR4 blocking antibodies were from Imgenex Corp ...
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Papers on TLR4
Primary role for TLR-driven TNF rather than cytosolic immune detection in restricting Coxiella burnetii phase II replication within mouse macrophages.
New
Shin et al., Ribeirão Preto, Brazil. In Infect Immun, Feb 2016
However, eliminating Toll-like receptor (TLR) 2 permits bacterial replication, indicating that restriction of bacterial replication is immune-mediated.
Roles of TLR2, TLR4, and MyD88 during pulmonary Coxiella burnetii infection.
New
Jutila et al., Bozeman, United States. In Infect Immun, Feb 2016
Previous studies examined the roles of the innate immune system receptors, TLR2 and TLR4, in peripheral infection models and described minimal phenotypes in specific gene deletion animals compared to their wildtype controls.
Effect of yeast-derived products and distillers dried grains with solubles (DDGS) on antibody-mediated immune response and gene expression of pattern recognition receptors and cytokines in broiler chickens immunized with T-cell dependent antigens.
New
Slominski et al., Winnipeg, Canada. In Poult Sci, Feb 2016
On d 35, 5 birds per treatment were euthanized and the tissue samples from the cecal tonsils were collected to assess the gene expression of toll-like receptors TLR2b, TLR4, and TLR21, monocyte mannose receptor (MMR), and cytokines IL-10, IL-13, IL-4, IL-12p35, and IFN-γ.
Interleukin-1 and inflammasomes in ALD/AAH and NAFLD/NASH.
Review
New
Szabo et al., Innsbruck, Austria. In Hepatology, Feb 2016
In ALD, chronic ethanol exposure sensitizes Kupffer cells to activation by lipopolysaccharides via Toll-like receptors (TLR), e.g., TLR4.
NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.
New
Impact
Machida et al., Los Angeles, United States. In Cell Metab, Feb 2016
Here, we show that NANOG is induced by Toll-like receptor 4 (TLR4) signaling via phosphorylation of E2F1 and that downregulation of Nanog slows down hepatocellular carcinoma (HCC) progression induced by alcohol western diet and hepatitis C virus protein in mice.
Ischaemic and inflammatory injury in renal graft from brain death donation: an update review.
Review
New
Ma et al., Wenzhou, China. In J Anesth, Feb 2016
This includes ischaemia and consequently the priming of the organ during storage for ischaemia reperfusion injury (IRI) on implantation and the importance of the innate immune system which can be activated via multiple pathways, often via TLR-4, and the consequent production of danger-associated molecular patterns.
Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells.
New
Impact
Lennon-Duménil et al., France. In Nat Cell Biol, Jan 2016
Following TLR4-MyD88-induced maturation, Arp2/3-dependent actin enrichment at the cell front is markedly reduced.
Human Milk Components Modulate Toll-Like Receptor-Mediated Inflammation.
Review
New
Newburg et al., Boston, United States. In Adv Nutr, Jan 2016
Toll-like receptor (TLR) signaling is central to innate immunity.
From infancy to aging: Biological and behavioral modifiers of Fetuin-A.
Review
New
Teran-Garcia et al., Urbana, United States. In Biochimie, Jan 2016
It may also promote insulin resistance by activation of toll-like receptor 4 pro-inflammatory cascade.
Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens.
New
Impact
Amigorena et al., Paris, France. In Immunity, Jan 2016
Additionally, DCs need to be activated through innate receptors, like Toll-like receptors (TLRs).
Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes.
New
Speer et al., Würzburg, Germany. In Plos One, Dec 2015
TLR2 and TLR4 mRNA and protein expression were not affected by CHF5633 and Curosurf®, neither in native nor in LPS-stimulated adult monocytes.
Expression of the Receptor for Advanced Glycation End Products in Epicardial Fat: Link with Tissue Thickness and Local Insulin Resistance in Coronary Artery Disease.
New
Corsi Romanelli et al., Milano, Italy. In J Diabetes Res, Dec 2015
EAT expression of RAGE, GLUT4, adiponenctin, GLO1, HMGB1, TLR-4, and MyD88 was analyzed by microarray.
Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria.
New
Impact
Kagan et al., Boston, United States. In Immunity, Dec 2015
Upon detection of bacterial lipopolysaccharides (LPS), CD14 induces an inflammatory endocytosis pathway that delivers Toll-like receptor 4 (TLR4) to endosomes.
Polymorphisms of Toll-Like Receptor 4 as a Risk Factor for Periodontitis: Meta-Analysis.
Review
New
Ziętek et al., Wrocław, Poland. In Adv Clin Exp Med, Nov 2015
BACKGROUND: Toll-like receptors play an important role in the recognition of periopathogens.
Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells.
New
Impact
Batista et al., Boston, United States. In Immunity, Nov 2015
Furthermore, in the absence of WIP, several receptors, namely the BCR, BAFFR, CXCR4, CXCR5, CD40, and TLR4, were impaired in promoting CD19 co-receptor activation and subsequent PI3 kinase (PI3K) signaling.
High mobility group [corrected] box 1 mediates neutrophil recruitment in myocardial ischemia-reperfusion injury through toll like receptor 4-related pathway.
GeneRIF
Jiang et al., Yichang, China. In Gene, 2012
HMGB1 plays a central role in recruiting neutrophils during myocardial I/R leading to worsened myocardial I/R injury. This recruitment mechanism is possibly due to its inflammatory and chemokine functions based on the TLR4-dependent pathway.
Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice.
GeneRIF
Hellman et al., San Francisco, United States. In Anesthesiology, 2012
alveolar macrophages and the pattern recognition receptor toll-like receptor-4 are involved in the generation of the early inflammatory response to lung ischemia-reperfusion injury
TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes.
GeneRIF
Wong et al., New Haven, United States. In Am J Physiol Heart Circ Physiol, 2012
TLR4 plays a role in regulating lipid accumulation in cardiac muscle after the onset of type 1 diabetes, which may contribute to cardiac dysfunction.
Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
GeneRIF
Watkins et al., Boulder, United States. In J Neurosci, 2012
The results of this study suggested that Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2.
GeneRIF
Blanco et al., Baltimore, United States. In Mbio, 2011
Respiratory syncytial virus F protein requires MD-2 for the induction of the TLR4-mediated inflammatory response.
More papers using TLR4 antibodies
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
Supplier
Zheng Song Guo, In PLoS ONE, 2004
... The caveolin-1 and TLR4 cDNA plasmids were supplied from Origene Technologies (Rockville, MD), and ...
Intracellularly expressed TLR3s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium
Supplier
Yokochi Takashi et al., In BMC Cancer, 2003
... Phycoerythrin (PE)-conjugated anti-human TLR-4 antibody was obtained from eBioscience, San Diego, CA, USA ...
Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA.
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Zimmer Jacques, In PLoS ONE, 2003
... TLR2-neutralizing mAb (clone mT2.4) was from Abcam (Cambridge, UK) and anti-TLR4 mAb (clone MTS510) from BioLegend (San Diego, CA) ...
Involvement of corticotropin-releasing hormone receptor subtypes 1 and 2 in peripheral opioid-mediated inhibition of inflammatory pain.
Supplier
Bishai William, In PLoS Pathogens, 2002
... Anti-TLR-2-phycoerythrin (PE, clone TL2.1) and anti-TLR-4-PE (clone HTA125) as well as mouse IgG2a were obtained from eBioscience, San Diego, CA, USA ...
A differential role for the mitogen activated protein kinases in lipopolysaccharide signaling: The MEK/ERK pathway is not essential for nitric oxide and interleukin 1β production
Supplier
Syahida Ahmad et al., In International Journal of Molecular Sciences, 2001
... p65, ERK1/2, pERK1/2, p38, pp38, I-κB, pI-κB, HRP conjugated anti-β-actin, fluorescein isothiocynate (FIT-C) conjugated anti-mouse TLR-4 and Peridinin chlorophyll protein complex (PerCP) conjugated anti-mouse CD-14 from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Toll-like Receptor 4 Resides in the Golgi Apparatus and Colocalizes with Internalized Lipopolysaccharide in Intestinal Epithelial Cells
Supplier
Richter-Dahlfors Agneta et al., In The Journal of Experimental Medicine, 2000
... The goat anti-TLR4 peptide antibody (sc-12511) was purchased from Santa Cruz Biotechnology, Inc ...
Intimate adhesion of Neisseria meningitidis to human epithelial cells is under the control of the crgA gene, a novel LysR-type transcriptional regulator.
Supplier
Roy Craig R., In PLoS Pathogens, 1999
... Neutralizing anti-TLR4 mAb (clone HTA125) was from eBioscience (Hatfield, UK) ...
Urokinase type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: dependence on extracellular matrix components
Supplier
Redmond H P et al., In British Journal of Cancer, 1996
... Anti-TLR-4-blocking mAb (clone, HTA-125), FITC-conjugated anti-TLR-4 mAb and isotype-control Abs were from eBioscience (San Diego, CA, USA) ...
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