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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Toll-like receptor 3

TLR3, Toll-Like Receptor 3
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using TLR3 antibodies
Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity
Tai Ming-Hong et al., In Journal of Biomedical Science, 2003
... The slides were then washed twice with PBS, incubated with TLR3 antibody (1:2000 dilution; Abcam, Cambridge, MA, USA) at ...
Papers on TLR3
Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats.
Lu et al., Xi'an, China. In Scand J Immunol, 2012
we conclude that overexpression of splenic TLR3 is strongly associated with arthritis in rats
Toll-like receptor 3 polymorphism and its association with hepatitis B virus infection in Saudi Arabian patients.
Almajhdi et al., Riyadh, Saudi Arabia. In J Med Virol, 2012
Genetic variations in the TLR3 gene could affect the outcome of hepatitis B virus infection among Saudis.
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.
Casanova et al., New York City, United States. In J Exp Med, 2012
TBK1 is essential for the TLR3- and IFN-dependent control of HSV-1 in the central nervous system
Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells.
Komano et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2012
These data clearly indicated that retroviral infection exemplified by xenotropic murine leukemia virus-relamoted virus activates the TLR3 signal in human cells.
Toll-like receptor 3 activation affects serotonin transporter activity and expression in human enterocyte-like Caco-2 cells.
Alcalde et al., Zaragoza, Spain. In Cell Physiol Biochem, 2011
TLR3 inhibits SERT activity, which may increase 5-HT extracellular levels and contribute to the inflammatory response
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