Human Milk Components Modulate Toll-Like Receptor-Mediated Inflammation.
Boston, United States. In Adv Nutr, Jan 2016
Human milk on the whole is strongly anti-inflammatory, and contains abundant components that depress TLR signaling pathways: sTLR2 and sCD14 inhibit TLR2 signaling; sCD14, lactadherin, lactoferrin, and 2'-fucosyllactose attenuate TLR4 signaling; 3'-galactosyllactose inhibits TLR3 signaling, and β-defensin 2 inhibits TLR7 signaling.
Toll-like receptors: potential targets for lupus treatment.
Shanghai, China. In Acta Pharmacol Sin, Dec 2015
Genome-wide association studies, experimental mouse models and clinical sample studies have provided evidence for the involvement of TLRs, including TLR2/4, TLR5, TLR3 and TLR7/8/9, in SLE pathogenesis.
[Mechanisms of Epstein-Barr Virus-Mediated Oncogenesis].
Kōbe, Japan. In Gan To Kagaku Ryoho, Oct 2015
However, it has also been demonstrated that EBER, which is expected to have a double-stranded RNA(dsRNA)structure, triggers signal transduction via host viral RNA sensors, RIG-I and TLR3, causing EBV-associated pathogenesis, including carcinogenesis.