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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Toll-like receptor 12

TLR12
Top mentioned proteins: TLR11, profilin, TLR5, TLR7, CAN
Papers on TLR12
The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.
New
Jankovic et al., Bethesda, United States. In J Immunol, Feb 2016
However, murine innate recognition of toxoplasma depends on the interaction of parasite profilin with TLR11 and TLR12, two receptors that are functionally absent in humans.
Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice.
Tschirren et al., Zürich, Switzerland. In Infect Genet Evol, 2014
Of particular importance appear to be the innate immune receptors Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12), which recognise T. gondii profilin and initiate immune responses against the parasite.
Toxoplasma gondii profilin promotes recruitment of Ly6Chi CCR2+ inflammatory monocytes that can confer resistance to bacterial infection.
Knoll et al., Madison, United States. In Plos Pathog, 2014
We demonstrate that a single TLR11/TLR12 ligand profilin (TgPRF) was sufficient to reduce bacterial burdens similar to T. gondii chronic infection.
Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.
Review
Sher et al., Belo Horizonte, Brazil. In Cell Host Microbe, 2014
Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans.
Identification and functional characterization of nonmammalian Toll-like receptor 20.
Wiegertjes et al., Wageningen, Netherlands. In Immunogenetics, 2014
Phylogenetic analyses place Tlr20 in the TLR11 family closest to Tlr11 and Tlr12, which sense ligands from protozoan parasites in the mouse.
Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin.
Yarovinsky et al., Dallas, United States. In J Immunol, 2013
In this study, we establish that, in addition to TLR11, TLR12 recognizes the profilin protein of the protozoan parasite Toxoplasma gondii and regulates IL-12 production by DCs in response to the parasite.
Activation of human natural killer cells by the novel innate immune modulator recombinant Eimeria antigen.
Amalfitano et al., East Lansing, United States. In Hum Immunol, 2013
Human cells lack functional TLR11 and TLR12, suggesting that rEA would not be effective in providing beneficial immune activation in humans.
Comprehensive survey and genomic characterization of Toll-like receptors (TLRs) in channel catfish, Ictalurus punctatus: identification of novel fish TLRs.
Bengtén et al., United States. In Immunogenetics, 2013
The catfish have representatives of all the TLR types defined in vertebrates with the exception of TLR6, TLR10, TLR11, TLR12, TLR13, TLR15, TLR23, and TLR24.
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Impact
Ghosh et al., New York City, United States. In Immunity, 2013
We report that TLR12, a previously uncharacterized TLR, also recognized TgPRF.
Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.
Gazzinelli et al., Worcester, United States. In Cell Host Microbe, 2013
Investigating this further, we found that while parasite RNA and DNA activate innate immune responses via TLR7 and TLR9, TLR11 and TLR12 working as heterodimers are required for sensing and responding to Toxoplasma profilin.
UNC93B1 mediates differential trafficking of endosomal TLRs.
Barton et al., Berkeley, United States. In Elife, 2012
UNC93B1, a multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes.
Mouse estrous cycle regulation of vaginal versus uterine cytokines, chemokines, α-/β-defensins and TLRs.
Wira et al., United States. In Innate Immun, 2012
These studies further indicate that TLR5 and TLR12 in the uterus, and TLR1, TLR2, TLR5 and TLR13 in the vagina varies with stage of the estrous cycle, with some peaking at proestrus/estrus and others at diestrus.
Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice.
Park et al., Seoul, South Korea. In J Nutr Biochem, 2012
Furthermore, the magnitudes of the obesity-induced up-regulation of the TLR1, TLR4, TLR5, TLR8, TLR9, and TLR12 genes and most of the downstream signaling molecules and target cytokine genes in the visceral adipose tissue were greater in the DIO mice than in the ob/ob mice.
Uncovering genes and regulatory pathways related to urinary albumin excretion.
Korstanje et al., Bar Harbor, United States. In J Am Soc Nephrol, 2011
By combining data from several sources and by utilizing gene expression data, we identified Tlr12 as a likely candidate for the Chr 4 QTL.
A leucine-rich repeat assembly approach for homology modeling of the human TLR5-10 and mouse TLR11-13 ectodomains.
Stark et al., München, Germany. In J Mol Model, 2011
With this method, we also constructed ectodomain models of human TLR5, TLR6, TLR7, TLR8, TLR9, and TLR10 and mouse TLR11, TLR12, and TLR13 that can be used as first passes for a computational simulation of ligand docking or to design mutation experiments.
Expression and distribution of Toll-like receptors 11-13 in the brain during murine neurocysticercosis.
GeneRIF
Teale et al., San Antonio, United States. In J Neuroinflammation, 2007
TLRs 11-13 are expressed in normal and parasite infected mouse brains. This suggests a role for them in central nervous system infections.
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