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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Toll-like receptor 11

Top mentioned proteins: profilin, TLR12, TLR5, CAN, MyD88
Papers on TLR11
The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.
Jankovic et al., Bethesda, United States. In J Immunol, Feb 2016
However, murine innate recognition of toxoplasma depends on the interaction of parasite profilin with TLR11 and TLR12, two receptors that are functionally absent in humans.
Structural and evolutionary characteristics of fish-specific TLR19.
Yin et al., Jinan, China. In Fish Shellfish Immunol, Nov 2015
In present study, a phylogenetic analysis showed that TLR19 belonged to family 11, and clustered with TLR20 and TLR11/12 on the evolutionary tree.
Role of Toll-like receptors in diabetic renal lesions in a miniature pig model.
Chen et al., Beijing, China. In Sci Adv, Jun 2015
Functional and pathological markers, expression and activation of endogenous TLR ligands [HSP70 (heat shock protein 70) and HMGB1], TLR1 to TLR11 and their downstream signaling pathway molecules (MyD88, IRAK-1, and IRF-3), nuclear factor κB (NF-κB) signaling pathway molecules (IKKβ, IκBα, and NF-κBp65), inflammatory cytokines [IL-6 (interleukin-6), MIP-2, MCP-1, CCL5, and VCAM-1 (vascular cell adhesion molecule-1)], and infiltration of inflammatory cells were systematically evaluated.
Identification and characterisation of TLR18-21 genes in Atlantic salmon (Salmo salar).
Secombes et al., Paris, France. In Fish Shellfish Immunol, 2014
Phylogenetic analysis revealed that teleost TLR19-21 are closely related with murine TLR11-TLR13, whilst teleost TLR18 groups with mammalian TLR1, 2, 6 and 10.
Toxoplasma gondii profilin promotes recruitment of Ly6Chi CCR2+ inflammatory monocytes that can confer resistance to bacterial infection.
Knoll et al., Madison, United States. In Plos Pathog, 2014
We demonstrate that a single TLR11/TLR12 ligand profilin (TgPRF) was sufficient to reduce bacterial burdens similar to T. gondii chronic infection.
Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.
Sher et al., Belo Horizonte, Brazil. In Cell Host Microbe, 2014
Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans.
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Ghosh et al., New York City, United States. In Immunity, 2013
Toll-like receptor 11 (TLR11) recognizes T. gondii profilin (TgPRF) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii-infected mice.
A mouse model of Salmonella typhi infection.
Ghosh et al., New York City, United States. In Cell, 2012
We now report that flagellin from Salmonella spp. is recognized in mouse intestine by Toll-like receptor 11 (TLR11).
Innate responses to Toxoplasma gondii in mice and humans.
Yarovinsky et al., Dallas, United States. In Trends Parasitol, 2011
Recent studies have established that TLR11 plays a dominant role in sensing T. gondii.
UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii.
Yarovinsky et al., Dallas, United States. In J Biol Chem, 2011
association with UNC93B1 and the intracellular localization of TLRs are not unique features of nucleic acid-sensing TLRs but is also essential for TLR11-dependent recognition of T. gondii profilin and for host protection against this parasite
Transcriptional regulation of Tlr11 gene expression in epithelial cells.
Zhang et al., United States. In J Biol Chem, 2009
Data demonstrate that transcription of the Tlr11 gene is regulated through epithelium-specific transcription factors and IRF-8.
Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology.
Sher et al., Dallas, United States. In J Immunol, 2009
TLR11-deficient mice develop an abnormal immunopathological response to Toxoplasma gondii, as the result of non-toll-like receptor dependent activation of interferon-gamma secretion by natural killer cells in response to the infection.
Expression and distribution of Toll-like receptors 11-13 in the brain during murine neurocysticercosis.
Teale et al., San Antonio, United States. In J Neuroinflammation, 2007
TLRs 11-13 are expressed in normal and parasite infected mouse brains. This suggests a role for them in central nervous system infections.
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.
Rock et al., Worcester, United States. In Nat Med, 2007
Analysis of the contribution of Myd88-dependent receptors to this response revealed only a minor reduction in mice doubly deficient in Toll-like receptor 2 (Tlr2) and Tlr4 and normal responses in mice lacking Tlr1, Tlr3, Tlr6, Tlr7, Tlr9, Tlr11 or the interleukin-18 receptor (IL-18R).
Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response.
Sher et al., Bethesda, United States. In Immunity, 2006
The immunogenicity of Toxoplasma gondii profilin was entirely dependent on both TLR11 recognition and signaling through the adaptor myeloid differentiation factor 88 (MyD88).
Toll-like receptor recognition of Toxoplasma gondii.
Sher et al., Bethesda, United States. In Int J Parasitol, 2006
In the following review, we summarise the evidence for specific TLR function in host resistance to T. gondii focusing on the recent discovery in the parasite of a profilin-like ligand that potently stimulates TLR11 and regulates the production of IL-12, a cytokine necessary for the protective IFN-gamma response.
'Toll' gates for future immunotherapy.
Akira et al., Suita, Japan. In Curr Pharm Des, 2005
urinary Tamm-Horsfall glycoprotein as a TLR4 ligand, siRNA as TLR3 or 7 ligand, Plasmodium falciparum Hemozoin as a TLR9 ligand, Profilin-like protein in Toxoplasma gondii as a TLR11 ligand) and antagonists (G-rich oligodeoxynucleotides as antagonist for TLR9) have been identified, and some of other TLR ligands are already under clinical trials.
Of mice and man: TLR11 (finally) finds profilin.
Golenbock et al., Worcester, United States. In Trends Immunol, 2005
One of the TLR mysteries relates to TLR11, a receptor present in mice, but not humans, and known to recognize uropathogenic Escherichia coli.
TLR11 activation of dendritic cells by a protozoan profilin-like protein.
Sher et al., Bethesda, United States. In Science, 2005
Toxoplasma gondii profilin activates dendritic cells through TLR11 and is the first chemically defined ligand for this TLR; TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection
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