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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nuclear receptor subfamily 2, group E, member 1

TLL, FRC, NR2E1, Tll1
This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, AGE
Papers on TLL
The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases.
Xiong et al., Chongqing, China. In Neurosci Bull, Feb 2016
UNASSIGNED: The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the central nervous system.
Lipases That Activate at High Solvent Polarities.
Bjerrum et al., Copenhagen, Denmark. In Biochemistry, Feb 2016
Thermomyces lanuginosus lipase (TlL) and related lipases become activated in low-polarity environments that exist at the water-lipid interface where a structural change of the "lid" region occurs.
TLX-Its Emerging Role for Neurogenesis in Health and Disease.
Funa et al., Thiruvananthapuram, India. In Mol Neurobiol, Feb 2016
UNASSIGNED: The orphan nuclear receptor TLX, also called NR2E1, is a factor important in the regulation of neural stem cell (NSC) self-renewal, neurogenesis, and maintenance.
Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque.
Abela et al., East Lansing, United States. In Eur Heart J, Jan 2016
Accumulation of low-density lipoprotein in the sub-intima provides esterified cholesterol (ESC) to macrophages and smooth muscle cells that convert it into free cholesterol (FRC) by cholesteryl ester hydrolases (CEHs).
Promoting protein self-association in non-glycosylated Thermomyces lanuginosus lipase based on crystal lattice contacts.
Otzen et al., Århus, Denmark. In Biochim Biophys Acta, Dec 2015
We have used the crystal structure of Thermomyces lanuginosus lipase (TlL) to identify and strengthen potential protein-protein interaction sites in solution.
Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping.
Barbe et al., Philadelphia, United States. In Bmc Musculoskelet Disord, Dec 2015
METHODS: Flexor digitorum muscles and tendons were collected from 22 young adult female rats performing a HRNF reaching task for 3 to 6 weeks, and 12 food restricted control (FRC) rats.
Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial.
RAPID Trial Study Group et al., Toronto, Canada. In Lancet, Aug 2015
Primary endpoints were CT lung density at total lung capacity (TLC) and functional residual capacity (FRC) combined, and the two separately, at 0, 3, 12, 21, and 24 months, analysed by modified intention to treat (patients needed at least one evaluable lung density measurement).
TLX: A master regulator for neural stem cell maintenance and neurogenesis.
Zhang et al., Dallas, United States. In Biochim Biophys Acta, Feb 2015
The orphan nuclear receptor TLX, also known as NR2E1, is an essential regulator of neural stem cell (NSC) self-renewal, maintenance, and neurogenesis.
The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.
Turley et al., Boston, United States. In Nat Immunol, 2015
Upon inflammation, CLEC-2 on mature DCs potently attenuated PDPN-mediated contractility, which resulted in FRC relaxation and reduced tissue stiffness.
Dendritic cells control fibroblastic reticular network tension and lymph node expansion.
Reis e Sousa et al., London, United Kingdom. In Nature, 2014
Engagement by CLEC-2 causes PDPN clustering and rapidly uncouples PDPN from RhoA/C activation, relaxing the actomyosin cytoskeleton and permitting FRC stretching.
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.
Lee et al., Houston, United States. In Mol Endocrinol, 2014
The nuclear orphan receptors for which endogenous ligands have not been identified include nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X gene), NR0B2 (small heterodimer partner), NR1D1/2 (Rev-Erbα/β), NR2C1 (testicular receptor 2), NR2C2 (testicular receptor 4), NR2E1 (tailless), NR2E3 (photoreceptor-specific NR [PNR]), NR2F1 chicken ovalbumin upstream promoter transcription factor 1 (COUP-TFI), NR2F2 (COUP-TFII), NR2F6 (v-erbA-related protein), NR4A1 (Nur77), NR4A2 (Nurr1), NR4A3 (Nor1), and NR6A1 (GCNF).
Multifunctional roles of reticular fibroblastic cells: more than meets the eye?
Marti et al., São Paulo, Brazil. In J Immunol Res, 2013
To this end, we focus this review on lymph nodes FRC characterization and discuss functional aspects such as production of cytokines and chemokines and their involvement in the immune response, seeking to establish whether certain subsets have a more functional specialization.
Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues.
Estes, Frederick, United States. In Immunol Rev, 2013
The underlying structural elements of LTs, fibroblastic reticular cell (FRC) network, not only form the architectural framework for these organs, but also play in integral role in the production and storage of cytokines needed for T-cell survival.
Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.
Ludewig et al., Sankt Gallen, Switzerland. In Immunity, 2013
Thus, myofibroblasic FRC precursors are able to generate the basic T cell zone infrastructure, whereas LTβR-dependent maturation of FRCs guarantees full immunocompetence and hence optimal LN function during infection.
Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice.
Simpson et al., Vancouver, Canada. In Mol Cell Biol, 2012
Cerebrum and olfactory bulb hypoplasia, hallmarks of the Nr2e1-null mice phenotype, were not fully corrected in animals harboring one functional copy of human NR2E1.
SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells.
Gage et al., Los Angeles, United States. In J Biol Chem, 2012
Sox2 plays an important role in Tlx transcription in cultured adult NSCs
The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function.
Estébanez-Perpiñá et al., Barcelona, Spain. In Plos One, 2011
BCL11A is a novel TLX coregulator that might be involved in TLX-dependent gene regulation in the brain.
miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells.
Shi et al., Duarte, United States. In Nat Commun, 2010
miR-137 forms a feedback regulatory loop with TLX and LSD1 to control the dynamics between neural stem cell proliferation and differentiation during neural development.
The drumstick gene acts cell-non-autonomously and triggers specification of the small intestine in the Drosophila hindgut.
Murakami et al., Yamaguchi, Japan. In Int J Dev Biol, 2010
drm is activated under the control of tll and triggers development of the small intestine cell-non-autonomously through some extracellular signaling
Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal.
Shi et al., Duarte, United States. In Nat Cell Biol, 2010
The nuclear receptor TLX (also known as NR2E1) is essential for adult neural stem cell self-renewal; however, the molecular mechanisms involved remain elusive.
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