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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tousled-like kinase 2

TLK2, serine/threonine kinase CK2, protein kinase Ualpha, PKU-alpha
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM, Apr 2004] (from NCBI)
Top mentioned proteins: serine-threonine protein kinase, Histone, CAN, POLYMERASE, HAD
Papers on TLK2
Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
New
Weng et al., Guangzhou, China. In Oncotarget, Nov 2015
Protein kinase CK2 alpha (CK2α), one isoform of the catalytic subunit of serine/threonine kinase CK2, has been indicated to participate in tumorigenesis of various malignancies.
Exploratory biomarker analysis for treatment response in KRAS wild type metastatic colorectal cancer patients who received cetuximab plus irinotecan.
Kim et al., Seoul, South Korea. In Bmc Cancer, 2014
PSKH1, TLK2 and PHKG2 were overexpressed significantly in patients with the disease control to IC.
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer.
Ragan et al., Australia. In Biol Direct, 2014
Among the inferred targets are tousled-like kinase 2 (TLK2) and the deubiquitinating enzyme ubiquitin-specific-processing protease 7 (USP7) whose overexpression correlates with poor survival in cancers.
Stable knockdown of protein kinase CK2-alpha (CK2α) inhibits migration and invasion and induces inactivation of hedgehog signaling pathway in hepatocellular carcinoma Hep G2 cells.
Jiang et al., Shenyang, China. In Acta Histochem, 2014
Protein kinase CK2-alpha (CK2α), one isoform of the catalytic subunits of serine/threonine kinase CK2, has been indicated to participate in tumorigenesis of various malignancies, including hepatocellular carcinoma (HCC).
Purification, crystallization and preliminary X-ray diffraction analysis of the kinase domain of human tousled-like kinase 2.
Muñoz et al., Madrid, Spain. In Acta Crystallogr Sect F Struct Biol Commun, 2014
The two members of the family reported in humans, namely TLK1 and TLK2, localize to the cell nucleus and are capable of forming homo- or hetero-oligomers by themselves.
Protein kinase CK2 is a critical regulator of epithelial homeostasis in chronic intestinal inflammation.
Nusrat et al., Atlanta, United States. In Mucosal Immunol, 2013
Here, we report that during intestinal inflammation, multiple inflammatory cytokines promote the activity of a master regulator of cell proliferation and apoptosis, serine/threonine kinase CK2.
GSVD comparison of patient-matched normal and tumor aCGH profiles reveals global copy-number alterations predicting glioblastoma multiforme survival.
Alter et al., Salt Lake City, United States. In Plos One, 2011
These include the biochemically putative drug target, cell cycle-regulated serine/threonine kinase-encoding TLK2, the cyclin E1-encoding CCNE1, and the Rb-binding histone demethylase-encoding KDM5A.
On CK2 regulation of chronic lymphocytic leukemia cell viability.
Barata et al., Lisbon, Portugal. In Mol Cell Biochem, 2011
The protein serine/threonine kinase CK2 is frequently upregulated in cancer, and it is overexpressed and hyperactivated in primary CLL cells from untreated patients.
The expression of Tousled kinases in CaP cell lines and its relation to radiation response and DSB repair.
GeneRIF
De Benedetti et al., Shreveport, United States. In Prostate, 2011
TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks.
Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer.
Couch et al., Rochester, United States. In Breast Cancer Res Treat, 2011
In gene-level analyses, CDC25C, SCC1/RAD21, TLK2, and SMC6L1 were associated (P < 0.05) with overall breast cancer risk, CDC6, CDC27, SUMO3, RASSF1, KIF2, and CDC14A were associated with high grade breast cancer risk, and EIF3S10 and CDC25A were associated with both.
Regulation of taurine transport systems by protein kinase CK2 in mammalian cells.
Review
Hansen et al., Copenhagen, Denmark. In Cell Physiol Biochem, 2010
The ubiquitously and evolutionary conserved serine/threonine kinase CK2 promotes cell survival and suppresses apoptosis.
Mll5 is required for normal spermatogenesis.
Aparicio et al., Vancouver, Canada. In Plos One, 2010
Moreover, this study identifies Tlk2, Utx, Gpr64, Sult4a1, Rap2ip, Vstm2 and HoxA10 as possible Mll5 targets that together may account for the observed spermatozoa maturation defects.
The pleiotropic protein kinase CK2 phosphorylates HTLV-1 Tax protein in vitro, targeting its PDZ-binding motif.
Bertazzoni et al., Verona, Italy. In Virus Genes, 2010
Here we show that Tax-1 is phosphorylated in vitro by the pleiotropic human serine/threonine kinase CK2 at three residues, Ser-336, Ser-344 and Thr-351, close to and within its C-terminal PDZ-binding motif.
Caenorhabditis elegans TLK-1 controls cytokinesis by localizing AIR-2/Aurora B to midzone microtubules.
Wu et al., Taipei, Taiwan. In Biochem Biophys Res Commun, 2010
Interestingly, human TLK2 could functionally substitute for tlk-1, suggesting that the mitotic roles of TLK members might be evolutionarily conserved.
Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.
GeneRIF
Moshkin et al., Genève, Switzerland. In Plos One, 2008
ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases.
Significance of protein kinase CK2 nuclear signaling in neoplasia.
Review
Tawfic et al., Minneapolis, United States. In J Cell Biochem Suppl, 1999
We propose that the protein serine/threonine kinase CK2 (formerly casein kinase II) is one such agent that is involved in signal transduction in the nuclear matrix and chromatin in response to a variety of stimuli.
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