Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer.
Rochester, United States. In Breast Cancer Res Treat, 2011
In gene-level analyses, CDC25C, SCC1/RAD21, TLK2, and SMC6L1 were associated (P < 0.05) with overall breast cancer risk, CDC6, CDC27, SUMO3, RASSF1, KIF2, and CDC14A were associated with high grade breast cancer risk, and EIF3S10 and CDC25A were associated with both.
Mll5 is required for normal spermatogenesis.
Vancouver, Canada. In Plos One, 2010
Moreover, this study identifies Tlk2, Utx, Gpr64, Sult4a1, Rap2ip, Vstm2 and HoxA10 as possible Mll5 targets that together may account for the observed spermatozoa maturation defects.
Significance of protein kinase CK2 nuclear signaling in neoplasia.
Minneapolis, United States. In J Cell Biochem Suppl, 1999
We propose that the protein serine/threonine kinase CK2 (formerly casein kinase II) is one such agent that is involved in signal transduction in the nuclear matrix and chromatin in response to a variety of stimuli.