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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transducin-like enhancer of split 2

TLE2, Grg2, ESG2
Top mentioned proteins: TLE3, CAN, FATE, OUT, galectin-1
Papers on TLE2
Brief report: Rx1 defines retinal precursor identity by repressing alternative fates through the activation of TLE2 and Hes4.
Andreazzoli et al., Pisa, Italy. In Stem Cells, 2013
Unexpectedly, we also observed that Rx1, mainly through the activation of the transcriptional repressors TLE2 and Hes4, is necessary and sufficient to inhibit endomesodermal gene expression in retinal precursors of the eye field.
Molecular characterization of a novel, de novo, cryptic interstitial deletion on 19p13.3 in a child with a cutis aplasia and multiple congenital anomalies.
Curtis et al., Cleveland, United States. In Am J Med Genet A, 2010
We found the deletion to encompass 71 genes, two of which appear to be good candidates for the patient's observed craniofacial and cardiac anomalies: guanine nucleotide binding protein (G protein), alpha 11 (Gq class)(GNA11), and Transducin-like Enhancer of Split 2 (E(sp1) homolog, Drosophila)(TLE2).
FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation.
Papalopulu et al., Manchester, United Kingdom. In Development, 2010
Here, we show that interaction of FoxG1 with TLE2, a Xenopus tropicalis co-repressor of the Groucho/TLE family, is crucial for regulating the early activity of FoxG1.
Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus.
Lan et al., Shanghai, China. In J Virol, 2010
Immunofluorescence analysis showed that TLE2 and RTA were colocalized in the same nuclear compartment in KSHV-infected cells.
Linkage and linkage disequilibrium scan for autism loci in an extended pedigree from Finland.
Peltonen et al., Finland. In Hum Mol Genet, 2009
Most promising candidate genes were TLE2 and TLE6 clustered at 19p13 and ATP1A2 at 1q23.
Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors.
Verjovski-Almeida et al., São Paulo, Brazil. In Biochem Biophys Res Commun, 2008
Microarray experiments and Real-time RT-PCR assays showed that alternatively spliced isoforms of TLE1, TLE2 an d TLE3 were preferentially expressed in prostate in comparison to liver and kidney tissues.
Folate receptor expression in pituitary adenomas cellular and molecular analysis.
Oyesiku et al., Atlanta, United States. In Vitam Horm, 2007
By real-time quantitative PCR, the genes involved in NOTCH3 pathway including NOTCH3, HES-1, and TLE2 were altered; the mRNA expression of FGFR1 was upregulated, and ERbeta mRNA was downregulated in FR overexpressing cells.
Expression of Groucho/TLE proteins during pancreas development.
Helgason et al., Vancouver, Canada. In Bmc Dev Biol, 2007
We then show that Tle2 can interact with Nkx2-2, Hes1, Arx, and Nkx6-1 which are all critical factors in pancreas development.
Evolution of the Groucho/Tle gene family: gene organization and duplication events.
Bajoghli, Vienna, Austria. In Dev Genes Evol, 2007
The genomic location and sequence similarities suggest that Aes/Grg5 and Tle6/Grg6 arose from duplication of the Tle2 gene; each evolved independently and acquired new functions as negative regulators of the other Tle proteins.
Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.
Sussel et al., Aurora, United States. In Development, 2007
To explore the mechanism by which Nkx2.2 functions as a repressor in the islet, we assessed the pancreatic expression of the Groucho co-repressors, Grg1, Grg2, Grg3 and Grg4 (Tle1-Tle4), which have been shown to interact with and modulate Nkx2.2 function.
Exploring the distinctive biological characteristics of pilocytic and low-grade diffuse astrocytomas using microarray gene expression profiles.
Decaestecker et al., Netherlands. In J Neuropathol Exp Neurol, 2006
Interestingly, a group of 6 genes (TIMP4, C1NH, CHAD, THBS4, IGFBP2, and TLE2) constitute an expression profile characteristic of grade I astrocytomas as compared with all other categories of tissue (normal brain, grade II, and high-grade astrocytomas).
On the modeling of breath-by-breath oxygen uptake kinetics at the onset of high-intensity exercises: simulated annealing vs. GRG2 method.
Francaux et al., Poitiers, France. In J Appl Physiol, 2006
To cope with these problems, an implementation of simulated annealing (SA) methods was compared with the GRG2 algorithm (a gradient-descent method known for its robustness).
Novel molecular signaling and classification of human clinically nonfunctional pituitary adenomas identified by gene expression profiling and proteomic analyses.
Oyesiku et al., Atlanta, United States. In Cancer Res, 2005
We observed changes in expression of SFRP1, TLE2, PITX2, NOTCH3, and DLK1, suggesting that the developmental Wnt and Notch pathways are activated and important for the progression of nonfunctional pituitary adenomas.
Duplicated members of the Groucho/Tle gene family in fish.
Czerny et al., Vienna, Austria. In Dev Dyn, 2005
Database searches of genomic sequences revealed an identical set of Tle paralogues being present in distantly related fish species, indicating duplicated Tle2 and Tle3 genes for the complete teleost lineage.
Meningioma transcript profiles reveal deregulated Notch signaling pathway.
Lal et al., San Francisco, United States. In Cancer Res, 2005
A novel finding from this screen is the induction of three components of the Notch signaling pathway: the transcription factor, hairy and enhancer of Split1 (HES1) and two members of the Groucho/transducin-like enhancer of Split family of corepressors, TLE2 and TLE3.
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