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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transketolase-like 1

TKR, TKTL1
The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: transketolase, HAD, CAN, AGE, V1a
Papers on TKR
Mechanisms of trophoblast migration, endometrial angiogenesis in preeclampsia: the role of decorin.
New
Nandi et al., London, Canada. In Cell Adh Migr, Feb 2016
Biological functions of DCN include: collagen assembly, myogenesis, tissue repair and regulation of cell adhesion and migration by binding to ECM molecules or antagonising multiple tyrosine kinase receptors (TKR) including EGFR, IGF-IR, HGFR and VEGFR-2.
Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes.
New
Osman et al., Australia. In Cell Signal, Jan 2016
The G protein-coupled receptor for thrombin can transactivate protein tyrosine kinase receptors (PTKR) and we have recently established that it can also transactivate serine/threonine kinase receptors (S/TKR).
Model-based evaluation of cost-effectiveness of Nerve Growth Factor Inhibitors in Knee Osteoarthritis: Impact of drug cost, toxicity, and means of administration.
New
Katz et al., Boston, United States. In Osteoarthritis Cartilage, Jan 2016
RESULTS: SOC in patients with high levels of pain led to an average discounted quality-adjusted life expectancy of 11.15 QALYs, a lifetime risk of TKR of 74%, and cumulative discounted direct medical costs of $148,700.
Comparison of Antagonist Muscle Activity During Walking Between Total Knee Replacement and Control Subjects Using Unnormalized Electromyography.
New
Wimmer et al., Chicago, United States. In J Arthroplasty, Jan 2016
BACKGROUND: Although satisfactory outcomes have been reported after total knee replacement (TKR), full recovery of muscle strength and physical function is rare.
Transketolase-like protein 1 expression predicts poor prognosis in colorectal cancer.
New
Haglund et al., Helsinki, Finland. In Cancer Biol Ther, Jan 2016
BACKGROUND: Transketolase-like protein 1 (TKTL1) is an isoform of tranketolase, a key protein in a cancer cell's glucose metabolism that causes rapid cell growth and controls the non-oxidative part of the pentose phosphate pathway (PPP).
Preliminary Report of a Neurokinin-Like Receptor Gene Sequence for the Nemertean Paranemertes sp.
New
Okazaki et al., Ogden, United States. In Zoolog Sci, Dec 2015
Our finding is the first report of a sequence amplified from Paranemertes sp. that may code for a small portion of a G-protein-coupled neuropeptide receptor with significant similarity to the TKR family, particularly the NKR-3 receptor isoform.
Restraint of Trophoblast Invasion of the Uterus by Decorin: Role in Pre-eclampsia.
Review
New
Lala et al., London, Canada. In Am J Reprod Immunol, Dec 2015
These functions were differentially mediated by binding of DCN to multiple tyrosine kinase receptors (TKR) including EGFR, IGFR1, and VEGFR2.
Analysis of circulating CD14+/CD16+ monocyte-derived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma.
New
Reinert et al., Tübingen, Germany. In Oral Surg Oral Med Oral Pathol Oral Radiol, Dec 2015
Moreover, epitope detection in monocytes (EDIM) technology was used to detect biomarkers Apo10 and transketolase-like-1 in CD14+/CD16+ MDMs.
Mechanical insights of oxythiamine compound as potent inhibitor for human transketolase-like protein 1 (TKTL1 protein).
New
Jeyakanthan et al., Kāraikkudi, India. In J Recept Signal Transduct Res, Nov 2015
Oxythiamine, an antimetabolite has been proved to be an efficient anticancerous compound in vitro, but its structural elucidation of the inhibitory mechanism has not yet been done against the human transketolase-like 1 protein (TKTL1).
TKTL1 and p63 are biomarkers for the poor prognosis of gastric cancer patients.
He et al., In Cancer Biomark, 2014
BACKGROUND: The significance of transketolase-like enzyme 1 (TKTL1) and p63 in the clinical progression and prognosis of gastric cancer patients has not been established.
The cost-effectiveness of oral direct factor Xa inhibitors compared with low-molecular-weight heparin for the prevention of venous thromboembolism prophylaxis in total hip or knee replacement surgery.
Review
Sobieraj et al., New Haven, United States. In Pharmacotherapy, 2013
We compared the cost-effectiveness of FXaIs with low-molecular-weight heparin (LMWH) in patients undergoing total hip replacement (THR) or total knee replacement (TKR) surgery.
Comparative effectiveness of new oral anticoagulants and standard thromboprophylaxis in patients having total hip or knee replacement: a systematic review.
Review
Williams et al., In Ann Intern Med, 2013
BACKGROUND: Pharmacologic thromboprophylaxis reduces the risk for venous thromboembolism after total hip replacement (THR) or total knee replacement (TKR).
Pharmacoeconomic implications of thromboprophylaxis with new oral anticoagulants after total hip or knee replacement in the USA.
Review
Nutescu, Chicago, United States. In Expert Opin Pharmacother, 2013
INTRODUCTION: Adequate thromboprophylaxis after total hip or knee replacement (THR or TKR) is essential to reduce the incidence of venous thromboembolism (VTE) and its associated complications.
Enhanced TKTL1 expression in malignant tumors of the ocular adnexa predicts clinical outcome.
GeneRIF
Auw-Haedrich et al., Freiburg, Germany. In Ophthalmology, 2012
TKTL1 is dysregulated in malignant tumors of the ocular adnexa, and enhanced expression seems to predict clinical outcome, especially the tumor recurrence rate.
TKTL-1 expression in lung cancer.
GeneRIF
Friedel et al., Stuttgart, Germany. In Pathol Res Pract, 2012
TKTL1 could be a target protein for improved therapeutic strategies in some cases of lung cancer.
Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression.
GeneRIF
Zur Hausen et al., Freiburg, Germany. In Pathology, 2011
TKTL1 overexpression is a new and independent predictor of survival for patients with non-small cell lung cancer
Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy.
GeneRIF
Erben et al., Mannheim, Germany. In Bmc Cancer, 2010
Investigated the expression of VEGFR-1, VEGFR-2 and TKTL1 in patients with LARC treated with neoadjuvant chemoradiotherapy and cetuximab. High TKTL1 expression significantly correlated with disease free survival.
Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation.
GeneRIF
Cascante et al., Barcelona, Spain. In Plos One, 2010
correlation of TKTL expression with tumor stage, probability of tumor recurrence and survival in colorectal cancer
Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila.
Impact
Bellen et al., Houston, United States. In Cell, 2002
These data suggest that Hrs and MVB formation function to downregulate TKR signaling.
Review
Williams et al., Washington, D.C., United States. In Unknown Journal, 0001
Venous thromboembolic (VTE) events are important causes of morbidity in elective total hip replacement (THR) and total knee replacement (TKR) procedures.
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