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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Jul 2015.

Titin

titin
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, Actin, HAD, nebulin, Calpain
Papers using titin antibodies
Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
Supplier
Gautel Mathias et al., In The Journal of Cell Biology, 1998
... For titin total human cardiac cDNA (CLONTECH Laboratories, Inc.) was used ...
M line–deficient titin causes cardiac lethality through impaired maturation of the sarcomere
Supplier
Gotthardt Michael et al., In The Journal of Cell Biology, 1997
... Generation of titin M-line knockout miceThe transgenic mice with loxP sites ...
Papers on titin
Genetics and genotype-phenotype correlations in Finnish patients with dilated cardiomyopathy.
New
Heliö et al., Helsinki, Finland. In Eur Heart J, 17 Jul 2015
Of these, 20 (53%) were titin (TTN) truncations (non-sense and frameshift) affecting all TTN transcripts.
Intermittent stretch training of rabbit plantarflexor muscles increases soleus mass and serial sarcomere number.
New
Herzog et al., Calgary, Canada. In J Appl Physiol, 15 Jul 2015
Neither titin isoform nor collagen amount was modified in the stretched compared with the control soleus muscle.
TU-F-CAMPUS-I-03: Quantitative Cardiac MRI Reveals Functional Abnormalities in Intrauterine Growth Restricted (IUGR) Baboons.
New
Nathanielsz et al., San Antonio, United States. In Med Phys, 30 Jun 2015
Results are consistent with reports of increased fibrosis and changes in the distribution of titin isoforms in IUGR fetal baboon heart tissues.
An update on laboratory diagnosis in myasthenia gravis.
Review
New
Frykman et al., Vancouver, Canada. In Clin Chim Acta, May 2015
They also broach over the striated antibodies, less frequent and clinically less useful such as anti-titin, -ryanodine, -agrin and -rapsyn.
From Tusko to Titin: The role for comparative physiology in an era of molecular discovery.
Review
New
Nishikawa et al., United States. In Am J Physiol Regul Integr Comp Physiol, May 2015
We discuss and speculate on the role of the largest known protein, titin (the third muscle filament), as a dynamic spring capable of storing and recovering elastic recoil potential energy in skeletal muscle.
Insights into alternative splicing of sarcomeric genes in the heart.
Review
New
Creemers et al., Amsterdam, Netherlands. In J Mol Cell Cardiol, Apr 2015
Through various examples (titin, myomesin, troponin T, tropomyosin and LDB3) we illustrate how alternative splicing regulates the functional properties of the sarcomere.
The genetic landscape of cardiomyopathy and its role in heart failure.
Review
New
Impact
Puckelwartz et al., Chicago, United States. In Cell Metab, Mar 2015
Dilated cardiomyopathy is often triggered by mutations that disrupt the giant protein titin.
The structure and regulation of human muscle α-actinin.
New
Impact
Djinović-Carugo et al., Vienna, Austria. In Cell, Jan 2015
The structure provides insight into the phosphoinositide-based mechanism controlling its interaction with sarcomeric proteins such as titin, lays a foundation for studying the impact of pathogenic mutations at molecular resolution, and is likely to be broadly relevant for the regulation of spectrin-like proteins.
Dynamic Alterations to α-Actinin Accompanying Sarcomere Disassembly and Reassembly during Cardiomyocyte Mitosis.
New
Schulz et al., Edmonton, Canada. In Plos One, Dec 2014
During myocyte mitosis, α-actinin and titin were disassembled as early as prometaphase.
Method for resolution and Western blotting of very large proteins using agarose electrophoresis.
New
Warren et al., Madison, United States. In Methods Mol Biol, Dec 2014
Complete transfer of proteins as large as titin (Mr 3,000-3,700 kDa) onto blots can be achieved.
A new paradigm for muscle contraction.
Review
New
Duvall et al., Calgary, Canada. In Front Physiol, Dec 2014
Just over a decade ago, we discovered that eccentric contractions were associated with a force that could not be assigned to actin and myosin, but was at least in part associated with the filamentous protein titin.
Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors.
New
Eisenberg et al., Valhalla, United States. In Stem Cells Int, Dec 2014
This latter outcome was indicated by their widespread expression of the primary sarcomeric proteins muscle α-actinin and titin.
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.
New
Impact
Fernández et al., New York City, United States. In Cell, Apr 2014
The giant elastic protein titin is a determinant factor in how much blood fills the left ventricle during diastole and thus in the etiology of heart disease.
High-speed force spectroscopy unfolds titin at the velocity of molecular dynamics simulations.
Impact
Scheuring et al., Marseille, France. In Science, 2013
The mechanical unfolding of the muscle protein titin by atomic force microscopy was a landmark in our understanding of single-biomolecule mechanics.
Mutational heterogeneity in cancer and the search for new cancer-associated genes.
Impact
Getz et al., Cambridge, United States. In Nature, 2013
The list includes many implausible genes (such as those encoding olfactory receptors and the muscle protein titin), suggesting extensive false-positive findings that overshadow true driver events.
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
GeneRIF
Sheikh et al., San Diego, United States. In J Biol Chem, 2012
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring.
GeneRIF
Fernández et al., London, United Kingdom. In J Biol Chem, 2012
Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring.
Titin mutation segregates with hereditary myopathy with early respiratory failure.
GeneRIF
Chinnery et al., Newcastle upon Tyne, United Kingdom. In Brain, 2012
This study presented that patients with hereditary myopathy with early respiratory failure linke with Titin mutation.
Hereditary myopathy with early respiratory failure associated with a mutation in A-band titin.
GeneRIF
Oldfors et al., Göteborg, Sweden. In Brain, 2012
This study identified three different Swedish Hereditary myopathy with early respiratory failure families with a new mutation in the A-band titin.
The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.
GeneRIF
Kihara et al., Sapporo, Japan. In Mol Cell, 2012
the Sjogren-Larsson syndrome-causative gene ALDH3A2 is responsible for conversion of the sphingosine 1-phosphate degradation product hexadecenal to hexadecenoic acid
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