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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2015.

Titin

titin
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, Actin, HAD, nebulin, V1a
Papers using titin antibodies
Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
Supplier
Gautel Mathias et al., In The Journal of Cell Biology, 1998
... For titin total human cardiac cDNA (CLONTECH Laboratories, Inc.) was used ...
M line–deficient titin causes cardiac lethality through impaired maturation of the sarcomere
Supplier
Gotthardt Michael et al., In The Journal of Cell Biology, 1997
... Generation of titin M-line knockout miceThe transgenic mice with loxP sites ...
Papers on titin
Sallimus and the dynamics of sarcomere assembly in Drosophila flight muscles.
New
Sparrow et al., Montréal, Canada. In J Mol Biol, 10 May 2015
Here we use a transgenic line with a GFP exon inserted into the Z-disc-proximal portion of Sallimus (Sls), also known as Drosophila titin, to observe sarcomere assembly during IFM development.
From Tusko to Titin: The role for comparative physiology in an era of molecular discovery.
New
Nishikawa et al., United States. In Am J Physiol Regul Integr Comp Physiol, 08 May 2015
We discuss and speculate on the role of the largest known protein, titin (the third muscle filament), as a dynamic spring capable of storing and recovering elastic recoil potential energy in skeletal muscle.
Thermodynamics of force-dependent folding and unfolding of small protein and nucleic acid structures.
New
Yan et al., Singapore, Singapore. In Integr Biol (camb), 24 Apr 2015
The extension probability distribution regardless of the structural state: , the free energy landscape: -kBT ln(ρ(ξ)(x)), and the probability of the states regardless of the extension: , are analyzed using the force-dependent structural transitions of the classic titin I27 domain as an example.
Targeted Inhibition of ANKRD1 Disrupts Sarcomeric ERK-GATA4 Signal Transduction and Abrogates Phenylephrine-Induced Cardiomyocyte Hypertrophy.
New
Lim et al., Nashville, United States. In Cardiovasc Res, 13 Apr 2015
Ankyrin repeat domain 1 (ANKRD1) is a transcriptional regulatory protein that also associates with sarcomeric titin; however, the exact role of ANKRD1 in the heart remains to be elucidated.
An Update on Laboratory Diagnosis in Myasthenia Gravis.
Review
New
Frykman et al., Vancouver, Canada. In Clin Chim Acta, 14 Mar 2015
They also broach over the striated antibodies, less frquent and clinically less useful such as anti-titin, -ryanodine, -agrin and -rapsyn.
Insights into alternative splicing of sarcomeric genes in the heart.
Review
New
Creemers et al., Amsterdam, Netherlands. In J Mol Cell Cardiol, 12 Mar 2015
Through various examples (titin, myomesin, troponin T, tropomyosin and LDB3) we illustrate how alternative splicing regulates the functional properties of the sarcomere.
The genetic landscape of cardiomyopathy and its role in heart failure.
Review
New
Impact
Puckelwartz et al., Chicago, United States. In Cell Metab, 03 Mar 2015
Dilated cardiomyopathy is often triggered by mutations that disrupt the giant protein titin.
The structure and regulation of human muscle α-actinin.
New
Impact
Djinović-Carugo et al., Vienna, Austria. In Cell, Jan 2015
The structure provides insight into the phosphoinositide-based mechanism controlling its interaction with sarcomeric proteins such as titin, lays a foundation for studying the impact of pathogenic mutations at molecular resolution, and is likely to be broadly relevant for the regulation of spectrin-like proteins.
A novel three-filament model of force generation in eccentric contraction of skeletal muscles.
New
Herzog et al., Graz, Austria. In Plos One, Dec 2014
We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production.
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.
New
Impact
Fernández et al., New York City, United States. In Cell, Apr 2014
The giant elastic protein titin is a determinant factor in how much blood fills the left ventricle during diastole and thus in the etiology of heart disease.
Pathogenic mechanisms in centronuclear myopathies.
Review
Gautel et al., London, United Kingdom. In Front Aging Neurosci, 2013
The most common forms of congenital myopathies with central nuclei have been attributed to X-linked recessive mutations in the MTM1 gene encoding myotubularin ("X-linked myotubular myopathy"), autosomal-dominant mutations in the DNM2 gene encoding dynamin-2 and the BIN1 gene encoding amphiphysin-2 (also named bridging integrator-1, BIN1, or SH3P9), and autosomal-recessive mutations in BIN1, the RYR1 gene encoding the skeletal muscle ryanodine receptor, and the TTN gene encoding titin.
High-speed force spectroscopy unfolds titin at the velocity of molecular dynamics simulations.
Impact
Scheuring et al., Marseille, France. In Science, 2013
The mechanical unfolding of the muscle protein titin by atomic force microscopy was a landmark in our understanding of single-biomolecule mechanics.
[Comparative studies of amyloid properties of muscles proteins and brain Abeta-peptides and identification of approaches to destruction of their amyloids in vitro].
Review
Podlubnaya et al., In Biofizika, 2013
In this review our data on the comparative study of amyloid properties of titin family proteins and brain Abeta-peptides are represented.
Mutational heterogeneity in cancer and the search for new cancer-associated genes.
Impact
Getz et al., Cambridge, United States. In Nature, 2013
The list includes many implausible genes (such as those encoding olfactory receptors and the muscle protein titin), suggesting extensive false-positive findings that overshadow true driver events.
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
GeneRIF
Sheikh et al., San Diego, United States. In J Biol Chem, 2012
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring.
GeneRIF
Fernández et al., London, United Kingdom. In J Biol Chem, 2012
Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring.
Titin mutation segregates with hereditary myopathy with early respiratory failure.
GeneRIF
Chinnery et al., Newcastle upon Tyne, United Kingdom. In Brain, 2012
This study presented that patients with hereditary myopathy with early respiratory failure linke with Titin mutation.
Hereditary myopathy with early respiratory failure associated with a mutation in A-band titin.
GeneRIF
Oldfors et al., Göteborg, Sweden. In Brain, 2012
This study identified three different Swedish Hereditary myopathy with early respiratory failure families with a new mutation in the A-band titin.
The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.
GeneRIF
Kihara et al., Sapporo, Japan. In Mol Cell, 2012
the Sjogren-Larsson syndrome-causative gene ALDH3A2 is responsible for conversion of the sphingosine 1-phosphate degradation product hexadecenal to hexadecenoic acid
Chronic ischemic viable myocardium in man: Aspects of dedifferentiation.
Borgers et al., Maastricht, Netherlands. In Cardiovasc Pathol, 1995
In the present study the expression and organizational pattern of contractile and cytoskeletal proteins such as titin, cardiotin, and α-smooth muscle actin were assessed in hibernating and normal myocardium because the expression and organization of these constituents have been related to certain stages of cardiomyocyte differentiation.
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