Resuscitation of a dead cardiomyocyte.
Louisville, United States. In Heart Fail Rev, 27 Sep 2015
The activation of calpains beyond the calpastatin-mediated inhibition due to extensive calcium harbor can lead to titin degradation, damage to the sarcomere and contractile dysfunction.
The structure and regulation of human muscle α-actinin.
Vienna, Austria. In Cell, Jan 2015
The structure provides insight into the phosphoinositide-based mechanism controlling its interaction with sarcomeric proteins such as titin, lays a foundation for studying the impact of pathogenic mutations at molecular resolution, and is likely to be broadly relevant for the regulation of spectrin-like proteins.
A new paradigm for muscle contraction.
Calgary, Canada. In Front Physiol, Dec 2014
Just over a decade ago, we discovered that eccentric contractions were associated with a force that could not be assigned to actin and myosin, but was at least in part associated with the filamentous protein titin.