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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Sep 2015.

Titin

titin
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, Actin, HAD, nebulin, Calpain
Papers using titin antibodies
Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
Supplier
Gautel Mathias et al., In The Journal of Cell Biology, 1998
... For titin total human cardiac cDNA (CLONTECH Laboratories, Inc.) was used ...
M line–deficient titin causes cardiac lethality through impaired maturation of the sarcomere
Supplier
Gotthardt Michael et al., In The Journal of Cell Biology, 1997
... Generation of titin M-line knockout miceThe transgenic mice with loxP sites ...
Papers on titin
An update on laboratory diagnosis in myasthenia gravis.
Review
New
Frykman et al., Vancouver, Canada. In Clin Chim Acta, 20 Oct 2015
They also broach over the striated antibodies, less frequent and clinically less useful such as anti-titin, -ryanodine, -agrin and -rapsyn.
HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
New
Impact
Seidman et al., Boston, United States. In Science, 28 Sep 2015
Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants (TTNtvs)] are the most common genetic cause for dilated cardiomyopathy (DCM), a major cause of heart failure and premature death.
Comparative Decline of the Protein Profiles of Nebulin in Response to Denervation in Skeletal Muscle.
New
Fong et al., Taiwan. In Biochem Biophys Res Commun, 28 Sep 2015
Work during the 1980s revealed the existence of two additional filaments: the giant filamentous proteins titin and nebulin.
Resuscitation of a dead cardiomyocyte.
New
Tyagi et al., Louisville, United States. In Heart Fail Rev, 27 Sep 2015
The activation of calpains beyond the calpastatin-mediated inhibition due to extensive calcium harbor can lead to titin degradation, damage to the sarcomere and contractile dysfunction.
Effect of Plyometrics on the Energy Cost of Running and MHC and Titin Isoforms.
New
Dumke et al., Missoula, United States. In Med Sci Sports Exerc, 07 Sep 2015
PURPOSE: To examine the effect of plyometric training on the energy cost of running (ECR, J[BULLET OPERATOR]kg[BULLET OPERATOR]min), titin and myosin heavy chain (MHC) isoforms.
Binding partners of the kinase domains in Drosophila obscurin and their effect on the structure of the flight muscle.
New
Bullard et al., York, United Kingdom. In J Cell Sci, 06 Sep 2015
UNASSIGNED: Drosophila obscurin (Unc-89) is a titin-like protein in the M-line of the muscle sarcomere.
From Tusko to Titin: the role for comparative physiology in an era of molecular discovery.
Review
New
Nishikawa et al., Flagstaff, United States. In Am J Physiol Regul Integr Comp Physiol, Jul 2015
We discuss and speculate on the role of the largest known protein, titin (the third muscle filament), as a dynamic spring capable of storing and recovering elastic recoil potential energy in skeletal muscle.
An update on laboratory diagnosis in myasthenia gravis.
Review
New
Frykman et al., Vancouver, Canada. In Clin Chim Acta, May 2015
They also broach over the striated antibodies, less frequent and clinically less useful such as anti-titin, -ryanodine, -agrin and -rapsyn.
Insights into alternative splicing of sarcomeric genes in the heart.
Review
New
Creemers et al., Amsterdam, Netherlands. In J Mol Cell Cardiol, Apr 2015
Through various examples (titin, myomesin, troponin T, tropomyosin and LDB3) we illustrate how alternative splicing regulates the functional properties of the sarcomere.
The genetic landscape of cardiomyopathy and its role in heart failure.
Review
New
Impact
Puckelwartz et al., Chicago, United States. In Cell Metab, Mar 2015
Dilated cardiomyopathy is often triggered by mutations that disrupt the giant protein titin.
The structure and regulation of human muscle α-actinin.
New
Impact
Djinović-Carugo et al., Vienna, Austria. In Cell, Jan 2015
The structure provides insight into the phosphoinositide-based mechanism controlling its interaction with sarcomeric proteins such as titin, lays a foundation for studying the impact of pathogenic mutations at molecular resolution, and is likely to be broadly relevant for the regulation of spectrin-like proteins.
A new paradigm for muscle contraction.
Review
New
Duvall et al., Calgary, Canada. In Front Physiol, Dec 2014
Just over a decade ago, we discovered that eccentric contractions were associated with a force that could not be assigned to actin and myosin, but was at least in part associated with the filamentous protein titin.
Differential Protein Expression in Congenital and Acquired Cholesteatomas.
New
Choi et al., Seoul, South Korea. In Plos One, Dec 2014
Of these 127 spots, 10 major spots revealed the presence of titin, forkhead transcription activator homolog (FKH 5-3), plectin 1, keratin 10, and leucine zipper protein 5 by MALDI-TOF/MS analysis.
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.
New
Impact
Fernández et al., New York City, United States. In Cell, Apr 2014
The giant elastic protein titin is a determinant factor in how much blood fills the left ventricle during diastole and thus in the etiology of heart disease.
High-speed force spectroscopy unfolds titin at the velocity of molecular dynamics simulations.
Impact
Scheuring et al., Marseille, France. In Science, 2013
The mechanical unfolding of the muscle protein titin by atomic force microscopy was a landmark in our understanding of single-biomolecule mechanics.
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
GeneRIF
Sheikh et al., San Diego, United States. In J Biol Chem, 2012
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring.
GeneRIF
Fernández et al., London, United Kingdom. In J Biol Chem, 2012
Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring.
Titin mutation segregates with hereditary myopathy with early respiratory failure.
GeneRIF
Chinnery et al., Newcastle upon Tyne, United Kingdom. In Brain, 2012
This study presented that patients with hereditary myopathy with early respiratory failure linke with Titin mutation.
Hereditary myopathy with early respiratory failure associated with a mutation in A-band titin.
GeneRIF
Oldfors et al., Göteborg, Sweden. In Brain, 2012
This study identified three different Swedish Hereditary myopathy with early respiratory failure families with a new mutation in the A-band titin.
The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.
GeneRIF
Kihara et al., Sapporo, Japan. In Mol Cell, 2012
the Sjogren-Larsson syndrome-causative gene ALDH3A2 is responsible for conversion of the sphingosine 1-phosphate degradation product hexadecenal to hexadecenoic acid
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