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TIMP metallopeptidase inhibitor 1

Tissue Inhibitor of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinases, tissue inhibitor of metalloproteinase
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MMP-9, MMP-2, TIMP-2, CAN, HAD
Papers using Tissue Inhibitor of Metalloproteinase-1 antibodies
Adenoviral-based overexpression of TIMP-1 reduces tissue damage in the joints TNF-transgenic mice
Supplier
Smolen J et al., In Arthritis Research, 2000
... Herein, the effect of an overexpression of tissue inhibitor of metalloproteinases (TIMP)-1, a physiological antagonist of metalloproteinases, was studied in the arthritis model of TNF-a-transgenic mice ...
Papers on Tissue Inhibitor of Metalloproteinase-1
Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in diagnosis of pleural effusion of malignant origin.
New
Di Carlo et al., Napoli, Italy. In Interact Cardiovasc Thorac Surg, Feb 2016
OBJECTIVES: The aim of the present study was to evaluate the diagnostic accuracy of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in differentiating benign from malignant exudative pleural effusions.
Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness.
Review
New
van der Kraan et al., Nijmegen, Netherlands. In Rheumatology (oxford), Nov 2015
In this regard, the following factors are discussed: TGF-β, connective tissue growth factor, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, tissue inhibitor of metalloproteinase 1, A disintegrin and metalloproteinase domain 12, urotensin-II, prostaglandin F2α and hyaluronan.
Biomarkers of drug-induced acute kidney injury in the adult.
Review
New
Endre et al., Brisbane, Australia. In Expert Opin Drug Metab Toxicol, Nov 2015
Clinical biomarkers of cell cycle arrest, tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 show promise but need further validation in clinical trials.
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.
New
Impact
Van Cutsem et al., Barcelona, Spain. In Lancet Oncol, Aug 2015
We also measured the concentration of 15 proteins of interest-angiopoietin 2, interleukin 6, interleukin 8, placental growth factor, soluble TIE-1, soluble VEGFR1, VEGF-A, VEGF-C, VEGF-D, VEGF-A isoform 121, bone morphogenetic protein 7, macrophage colony-stimulating factor, stromal cell-derived factor-1, tissue inhibitor of metalloproteinase 2, and von Willebrand factor-in plasma samples from 611 patients.
[Possibility of Using ELF Score as Index for Hepatic Fibrosis Evaluation].
Review
Asano, In Rinsho Byori, 2015
The Enhanced Liver Fibrosis (ELF) test is a simple blood test to create an ELF score by combining three markers: hyaluronic acid (HA), amino-terminal propeptide of type III procollagen (PIIINP), and tissue inhibitor of metalloproteinase 1 (TIMP-1).
Effects of Porcine Placenta Extract Ingestion on Ultraviolet B-induced Skin Damage in Hairless Mice.
Suh et al., Seoul, South Korea. In Korean J Food Sci Anim Resour, 2014
Additionally, oral administration of PPE significantly upregulated tissue inhibitor of metalloproteinase-1 (TIMP-1) and -2 mRNA expression levels compared with expression levels in the control group (p<0.05).
Effect of Porcine Placenta Extract from Subcritical Water Extraction on Photodamage in Human Keratinocytes.
Suh et al., Seoul, South Korea. In Korean J Food Sci Anim Resour, 2014
UVB treatment increased expression of tissue inhibitor of metalloproteinase 1 (TIMP-1), and this elevated expression was decreased by E-SPE treatment.
Prognostic value of tissue inhibitor of metalloproteinase-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis.
Review
Zhu et al., Shanghai, China. In Plos One, 2014
BACKGROUND AND OBJECTIVES: Tissue inhibitor of metalloproteinase-2 (TIMP-2) is a small secretory glycoprotein with anti-matrix metalloproteinase activity.
Serum and tissue biomarkers in aortic stenosis.
Cokkinos et al., Athens, Greece. In Glob Cardiol Sci Pract, 2014
We prospectively studied the following serum BMs in 60 patients with CAVS and compared them to 20 healthy controls, free from any cardiac disease: Matrix metalloproteinases (MMP) 2 and 9 and tissue inhibitor of metalloproteinase 1 (TIMP1), which regulate collagen turnover, inflammatory factors, i.e. tumor necrosis factor a (TNFa), interleukin 2 (IL2), transforming growth factor β1 (TGF-β1) which regulates fibrosis, fetuin-A (fet-A), osteopontin (OPN), osteoprotegerin (OPG), sclerostin (SOST), and relaxin-2 (RL2) which positively or negatively regulate calcification.
Morphological changes and expression of MMPs and TIMPs in rabbit degenerated lateral meniscus after PCL-transection.
Liao et al., Changsha, China. In Int J Clin Exp Med, 2014
The aim of this study was to investigate the influence of PCL fracture on lateral meniscus, including morphological changes, histological changes and roles of matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-13 (MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) expression level in the secondary injury.
Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironment.
Review
Bourboulia et al., Syracuse, United States. In Mol Cell Ther, 2013
However, recent studies demonstrate that TIMP family members also possess MMP-independent functions.
Serum MMP-9 and TIMP-1 concentrations and MMP-9 activity during surgery-induced inflammation in humans.
GeneRIF
Larsson et al., Uppsala, Sweden. In Clin Chem Lab Med, 2012
inflammatory state induced by elective surgery is associated with increased TIMP-1 response and MMP-9 activity in serum within a few days
[To study of the nasal mucosa remodeling of allergic rhinitis patients].
GeneRIF
Bai et al., Shanghai, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2012
TGF-beta1, MMP-9 and TIMP-1 may play a role in the tissue remodeling process in allergic rhinitis.
[Morphological features of placenta and expression of collagen-6, MMP-1 and TIMP-1 in placental membranes of women with premature rupture of membranes].
GeneRIF
Kvetnoĭ et al., In Arkh Patol, 2012
Morphological features of placenta and expression of collagen-6, MMP-1 and TIMP-1 in placental membranes of women with premature rupture of membranes
Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells.
GeneRIF
Nelson et al., München, Germany. In Plos One, 2011
TIMP-1 modified with a glycosylphosphatidylinositol anchor is bioactive in the nanogram range, enhances mesothelial cell proliferation, and stimulates rapid and efficient wound closure.
Expressions of MMPs and TIMP-1 in gastric ulcers may differentiate H. pylori-infected from NSAID-related ulcers.
GeneRIF
Sheu et al., Tainan City, Taiwan. In Scientificworldjournal, 2011
H. pylori-infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers
Intracellular targets of matrix metalloproteinase-2 in cardiac disease: rationale and therapeutic approaches.
Review
Impact
Schulz, Edmonton, Canada. In Annu Rev Pharmacol Toxicol, 2006
Oxidative stress activates full-length MMP-2 without need for proteolytic processing and inactivates an endogenous inhibitor, tissue inhibitor of metalloproteinase-4.
Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer.
Impact
Tan et al., Buffalo, United States. In J Clin Oncol, 2004
It has been shown that TIMP-1 may be a multifunctional protein.
A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.
Impact
Anand-Apte et al., Cleveland, United States. In Nat Med, 2003
Tissue inhibitor of metalloproteinases-3 (TIMP3) is one of four members of a family of proteins that were originally classified according to their ability to inhibit matrix metalloproteinases (MMP).
Identification of a stimulator of steroid hormone synthesis isolated from testis.
Impact
Papadopoulos et al., Washington, D.C., United States. In Science, 1995
The 28- and 38-kD proteins were shown to be identical to the tissue inhibitor of metalloproteinase-1 (TIMP-1) and the proenzyme form of cathepsin L, respectively.
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