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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Taste receptor, type 1, member 1

TIR1, T1R1
The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: ACID, SCF, Ubiquitin, CAN, V1a
Papers using TIR1 antibodies
Distinct hexokinases (HXKs) act as positive and negative regulators in sugar signalling pathways
Supplier
Moore Brandon d. et al., In Journal of Experimental Botany, 2007
... tir1, and transgenic lines expressing HXK1-HA or ...
Papers on TIR1
Metabotropic glutamate receptors are involved in the detection of IMP and l-amino acids by mouse taste sensory cells.
New
Delay et al., Burlington, United States. In Neuroscience, Jan 2016
These include the heterodimer taste receptor type 1 member 1 (T1r1)+taste receptor type 1 member 3 (T1r3), taste and brain variants of mGluR4 and mGluR1, and calcium sensors.
Auxin regulation of cell polarity in plants.
Review
New
Yang et al., Fuzhou, China. In Curr Opin Plant Biol, Dec 2015
Auxin is well known to control pattern formation and directional growth at the organ/tissue levels via the nuclear TIR1/AFB receptor-mediated transcriptional responses.
HSP90 regulates temperature-dependent seedling growth in Arabidopsis by stabilizing the auxin co-receptor F-box protein TIR1.
New
Estelle et al., San Diego, United States. In Nat Commun, Dec 2015
In this report, we show that increased temperature promotes rapid accumulation of the TIR1 auxin co-receptor, an effect that is dependent on the molecular chaperone HSP90.
The volatile 6-pentyl-2H-pyran-2-one from Trichoderma atroviride regulates Arabidopsis thaliana root morphogenesis via auxin signaling and ETHYLENE INSENSITIVE 2 functioning.
New
López-Bucio et al., Nicolás Romero, Mexico. In New Phytol, Dec 2015
TIR1, AFB2 and AFB3 auxin receptors and ARF7 and ARF19 transcription factors influenced the lateral root response to 6-PP, whereas EIN2 modulated 6-PP sensing in primary roots.
The role of pre-symbiotic auxin signaling in ectendomycorrhiza formation between the desert truffle Terfezia boudieri and Helianthemum sessiliflorum.
New
Sitrit et al., Beersheba, Israel. In Mycorrhiza, Dec 2015
Co-cultivation of Arabidopsis auxin receptor mutants tir1-1, tir1-1 afb2-3, tir1-1 afb1-3 afb2-3, and tir1-1 afb2-3 afb3-4 with Terfezia confirmed that auxin induces the observed root phenotype.
Revisiting Apoplastic Auxin Signaling Mediated by AUXIN BINDING PROTEIN 1.
Review
New
Kim et al., Chinju, South Korea. In Mol Cells, Dec 2015
It has been suggested that AUXIN BINDING PROTEIN 1 (ABP1) functions as an apoplastic auxin receptor, and is known to be involved in the post-transcriptional process, and largely independent of the already well-known SKP-cullin-F-box-transport inhibitor response (TIR1) /auxin signaling F-box (AFB) (SCF(TIR1/AFB)) pathway.
Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors.
Review
New
Bräuner-Osborne et al., Copenhagen, Denmark. In Eur J Pharmacol, Oct 2015
Class C is the smallest class with 22 human receptor subtypes including eight metabotropic glutamate (mGlu1-8) receptors, two GABAB receptors (GABAB1 and GABAB2), three taste receptors (T1R1-3), one calcium-sensing (CaS) receptor, one GPCR, class C, group 6, subtype A (GPRC6) receptor, and seven orphan receptors.
Cellular events of strigolactone signalling and their crosstalk with auxin in roots.
Review
New
Koltai, Israel. In J Exp Bot, Aug 2015
Strigolactones are also involved with the response to phosphate conditions in roots, acting by both dampening auxin transport via depletion of PIN2 from the plasma membrane and inducing TIR1 transcription to increase auxin perception.
Umami the Fifth Basic Taste: History of Studies on Receptor Mechanisms and Role as a Food Flavor.
Review
Kurihara, Aomori, Japan. In Biomed Res Int, 2014
Three umami receptors (T1R1 + T1R3, mGluR4, and mGluR1) were identified.
Changes in hormone flux and signaling in white spruce (Picea glauca) seeds during the transition from dormancy to germination in response to temperature cues.
Kermode et al., Vancouver, Canada. In Bmc Plant Biol, 2014
We contend that seed dormancy and germination may be partly mediated through the changing hormone concentrations and a modulation of interactions between central auxin-signaling pathway components (TIR1/AFB, Aux/IAA and ARF4).
Sensory biology. Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor.
Impact
Liberles et al., Cambridge, United States. In Science, 2014
Receptor expression studies revealed that the ancestral umami receptor (the T1R1-T1R3 heterodimer) was repurposed in hummingbirds to function as a carbohydrate receptor.
Auxin activates the plasma membrane H+-ATPase by phosphorylation during hypocotyl elongation in Arabidopsis.
GeneRIF
Kinoshita et al., Nagoya, Japan. In Plant Physiol, 2012
TIR1 auxin receptor family is not involved in auxin-induced H(+)-ATPase phosphorylation.
Umami taste receptor functions as an amino acid sensor via Gαs subunit in N1E-115 neuroblastoma cells.
GeneRIF
Ishii et al., Obihiro, Japan. In J Cell Biochem, 2012
examined the function of umami taste receptor, which has a dimeric protein structure composed of Tas1r1 and Tas1r3, as an amino acid sensor
A novel sensor to map auxin response and distribution at high spatio-temporal resolution.
Impact
Vernoux et al., Lyon, France. In Nature, 2012
We initially show that DII-VENUS abundance is dependent on auxin, its TIR1/AFBs co-receptors and proteasome activities.
Regulation of auxin response by miR393-targeted transport inhibitor response protein 1 is involved in normal development in Arabidopsis.
GeneRIF
Zhu et al., Hangzhou, China. In Plant Mol Biol, 2011
The interaction between miR393 and its target indicates a fine adjustment to the roles of the miR393-TIR1 module, which is required for auxin responses in plant development.
Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.
GeneRIF
Boekhoff et al., München, Germany. In Plos One, 2011
Data show that that Tas1r1 and Tas1r3 are expressed in murine and human spermatozoa.
miR393 and secondary siRNAs regulate expression of the TIR1/AFB2 auxin receptor clade and auxin-related development of Arabidopsis leaves.
GeneRIF
Vazquez et al., Basel, Switzerland. In Plant Physiol, 2011
miR393 and secondary siRNAs regulate expression of the TIR1
Auxin: a trigger for change in plant development.
Review
Impact
Friml et al., Gent, Belgium. In Cell, 2009
Individual cells interpret auxin largely by a nuclear signaling pathway that involves the F box protein TIR1 acting as an auxin receptor.
Mechanism of auxin-regulated gene expression in plants.
Review
Impact
Estelle et al., San Diego, United States. In Annu Rev Genet, 2008
Transcriptional output from these auxin signaling complexes is regulated by proteasome-mediated degradation that is triggered by interaction with auxin receptor-E3 ubiquitin ligases such SCF(TIR1).
Mechanism of auxin perception by the TIR1 ubiquitin ligase.
Impact
GeneRIF
Zheng et al., Seattle, United States. In Nature, 2007
crystal structures of the Arabidopsis TIR1-ASK1 complex, free and in complexes with three different auxin compounds and an Aux/IAA substrate peptide
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