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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TIMELESS interacting protein

Tipin, Timeless-interacting protein
Top mentioned proteins: Claspin, Chk1, CLOCK, POLYMERASE, RPA
Papers on Tipin
TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response.
New
Pagano et al., New York City, United States. In Cell Rep, Nov 2015
We show a robust physical interaction between PARP1 and the replication fork protein TIMELESS, distinct from the known TIMELESS-TIPIN complex, which activates the intra-S phase checkpoint.
TIPIN depletion leads to apoptosis in breast cancer cells.
New
Dubois et al., Paris, France. In Mol Oncol, Oct 2015
Gene-expression analyses for different breast cancer subtypes revealed significant overexpression of the Timeless-interacting protein (TIPIN), which is involved in the stability of DNA replication forks, in the highly proliferative associated TNBC samples.
Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability.
New
Baxter et al., Brighton, United Kingdom. In Proc Natl Acad Sci U S A, Sep 2015
However, generally, fork rotation and precatenation are actively inhibited by Timeless/Tof1 and Tipin/Csm3.
Systematic analysis of circadian genes using genome-wide cDNA microarrays in the inflammatory bowel disease transcriptome.
New
Latiano et al., In Chronobiol Int, Aug 2015
Conversely, ARNTL2, CRY1, CSNK1E, RORA and TIPIN were up-regulated, while NR1D2 and PER3 were down-regulated in UC.
Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.
New
Russell et al., San Francisco, United States. In G3 (bethesda), May 2015
Here, an epistatic mini-array profile reveals critical requirements for Brc1 in mutants that are defective in multiple DNA damage response pathways, including checkpoint signaling by Rad3-Rad26/ATR-ATRIP kinase, DNA repair by Smc5-Smc6 holocomplex, replication fork stabilization by Mrc1/claspin and Swi1-Swi3/Timeless-Tipin, and control of ubiquitin-regulated proteolysis by the COP9 signalosome (CSN).
Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex.
Mizuno et al., Martinsried, Germany. In Nucleic Acids Res, 2014
The Timeless-Tipin (Tim-Tipin) complex, also referred to as the fork protection complex, is involved in coordination of DNA replication.
A timeless but timely connection between replication and recombination.
Impact
Lichten et al., Paris, France. In Cell, 2014
Murakami and Keeney show that this coordination requires recruitment of the Dbf4-dependent kinase to the replication fork by the conserved TIM-TIPIN complex.
Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins.
Qian et al., Hong Kong, Hong Kong. In Febs J, 2014
UNLABELLED: Replication protein A subunit RPA32 contains a C-terminal domain that interacts with a variety of DNA damage response proteins including SMARCAL1, Tipin, UNG2 and XPA.
Tipin functions in the protection against topoisomerase I inhibitor.
Seki et al., Sendai, Japan. In J Biol Chem, 2014
The Timeless-Tipin complex, a component of the replication fork machinery, plays a role in replication checkpoint activation and stabilization of the replication fork.
Mta2 promotes Tipin-dependent maintenance of replication fork integrity.
Costanzo et al., London, United Kingdom. In Cell Cycle, 2013
Orderly progression of S phase requires the action of replisome-associated Tipin and Tim1 proteins, whose molecular function is poorly understood.
DNA replication and homologous recombination factors: acting together to maintain genome stability.
Review
Costanzo et al., London, United Kingdom. In Chromosoma, 2013
Key constituents of the Replisome are the Cdc45-Mcm2-7-GINS helicase and the And1-Claspin-Tipin-Tim1 complex, which coordinate DNA unwinding with polymerase alpha-, delta-, and epsilon- dependent DNA polymerization.
Local and global functions of Timeless and Tipin in replication fork protection.
Review
Noguchi et al., Philadelphia, United States. In Cell Cycle, 2012
The eukaryotic cell replicates its chromosomal DNA with almost absolute fidelity in the course of every cell cycle.
Mechanisms of replication fork protection: a safeguard for genome stability.
Review
Costanzo et al., London, United Kingdom. In Crit Rev Biochem Mol Biol, 2012
Both the ATR (ataxia telangiectasia and Rad3-related protein) kinase and the Replication pausing complex (RPC) components Tipin, Tim1 and Claspin play key roles in activating the intra S-phase checkpoint and in stabilizing the stalled replication forks.
The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virus.
GeneRIF
Lieberman et al., Philadelphia, United States. In J Virol, 2011
We now show that cellular DNA replication fork pausing and protection factors Timeless (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle.
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.
GeneRIF
Unsal-Kaçmaz et al., Chapel Hill, United States. In J Biol Chem, 2010
RPA-covered ssDNA not only supports recruitment and activation of ATR but also, through Tipin and Claspin, it plays an important role in the action of ATR on its critical downstream target Chk1
Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns.
Review
Costanzo et al., London, United Kingdom. In Embo Rep, 2010
The response to replication fork damage is monitored by conserved proteins, such as the TIPIN-TIM-CLASPIN complex.
Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion.
GeneRIF
Noguchi et al., Philadelphia, United States. In J Cell Sci, 2010
The results suggest that Timeless-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks.
Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion.
GeneRIF
Costanzo et al., Schwäbisch Hall, Germany. In Embo J, 2010
data indicate that Tipin/Tim1/And1 form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion
Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.
GeneRIF
Brown et al., Philadelphia, United States. In J Cell Biol, 2009
The tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.
Circadian proteins in the regulation of cell cycle and genotoxic stress responses.
Review
Antoch et al., Cleveland, United States. In Trends Cell Biol, 2007
Moreover, in complex with its recently identified partner, TIM-interacting protein (TIPIN), TIM interacts with components of the DNA replication system to regulate DNA replication processes under both normal and stress conditions.
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