TIPIN depletion leads to apoptosis in breast cancer cells.
Paris, France. In Mol Oncol, Oct 2015
Gene-expression analyses for different breast cancer subtypes revealed significant overexpression of the Timeless-interacting protein (TIPIN), which is involved in the stability of DNA replication forks, in the highly proliferative associated TNBC samples.
Mechanisms of replication fork protection: a safeguard for genome stability.
London, United Kingdom. In Crit Rev Biochem Mol Biol, 2012
Both the ATR (ataxia telangiectasia and Rad3-related protein) kinase and the Replication pausing complex (RPC) components Tipin, Tim1 and Claspin play key roles in activating the intra S-phase checkpoint and in stabilizing the stalled replication forks.