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Perilipin 3

TIP47
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: ADRP, Perilipin, ACID, S3-12, CAN
Papers using TIP47 antibodies
Mitochondria supply membranes for autophagosome biogenesis during starvation.
Supplier
Meurs Eliane F., In PLoS ONE, 2009
... GST, anti-GFP (Roche Diagnostics), QIAexpress Anti-His antibodies (Qiagen) against the His tag and guinea pig anti-TIP47 from Fitzgerald Industries International (Concord, MA, ...
Papers on TIP47
[Lipid droplet-associated proteins : Importance in steatosis, steatohepatitis and hepatocarcinogenesis].
New
Straub, Heidelberg, Germany. In Pathologe, Oct 2015
The lipid droplet (LD)-associated proteins perilipin, adipophilin, TIP47 ("tail interacting protein of 47 kDa"), S3-12 and myocardial LD protein (MLDP), so-called perilipins 1-5 (PAT family) govern formation, maintenance and degradation of LDs.
Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes.
New
Dembinska-Kiec et al., Kraków, Poland. In Biochim Biophys Acta, Sep 2015
Presence of eicosanoid acid (EPA) during the initial period of differentiation by elevation of Perilipin 3 protein (TIP47), may be responsible for smaller LD formation.
Epigenetic harnessing of HCV via modulating the lipid droplet-protein, TIP47, in HCV cell models.
New
Abdelaziz et al., Cairo, Egypt. In Febs Lett, Sep 2015
This study aimed at identifying potential microRNAs that modulate hepatic lipid droplets (LD) through targeting the Tail interacting protein of 47 kDa (TIP47) in HCV infection.
Short communication: Effect of inhibition of fatty acid synthase on triglyceride accumulation and effect on lipid metabolism genes in goat mammary epithelial cells.
New
Loor et al., Urbana, United States. In J Dairy Sci, May 2015
Consistent with the markedly lower expression of genes related to lipid droplet formation and secretion (TIP47, ADFP, BTN1A1, and XDH), cellular lipid droplets also were reduced sharply after incubation with C75 or adenovirus-short-hairpin-RNA.
Deleted in breast cancer 1 plays a functional role in adipocyte differentiation.
New
Fernández-Real et al., Girona, Spain. In Am J Physiol Endocrinol Metab, May 2015
In both VAT and SAT, DBC1 mRNA levels were negatively associated with BMI and positively associated with age and the expression of PPARγ, GLUT4, IRS1, lipogenic (FASN, ACACA), lipid droplet-associated genes (PLIN1, FSP27, ADRP, and TIP47), and lipolytic (ABDH5, AKAP, and PRKACA) genes but negatively associated with ADIPOQ in VAT.
Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.
New
Ratcliffe et al., Girona, Spain. In Diabetes, Mar 2015
PHD2 mRNA levels correlated positively with mRNA levels of AB-hydrolase domain containing-5, an activator of ATGL, and negatively with mRNA levels of lipid droplet proteins, perilipin, and TIP47 in human subcutaneous adipose tissue.
Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training.
GeneRIF
Tarnopolsky et al., Canada. In Appl Physiol Nutr Metab, 2012
PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content in female skeletal muscle.
Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice.
GeneRIF
Ahima et al., Philadelphia, United States. In Am J Physiol Regul Integr Comp Physiol, 2012
These findings show that TIP47 affects hepatic lipid and glucose metabolism and may be a target for the treatment of nonalcoholic fatty liver and related metabolic disorders.
Lipid droplet associated proteins: an emerging role in atherogenesis.
Review
Robenek et al., Münster, Germany. In Histol Histopathol, 2011
However, only more recently has it become apparent that a special set of lipid droplet associated proteins - the PAT protein family (perilipin, adipophilin, TIP47, S3-12 and OXPAT) - is fundamental to the formation, growth, stabilization and functions of lipid droplets.
TIP47 protects mitochondrial membrane integrity and inhibits oxidative-stress-induced cell death.
GeneRIF
Szigeti et al., Pécs, Hungary. In Febs Lett, 2010
Overexpression of tail interacting protein of 47 kDa (TIP47), but not its truncated form (t-TIP47) protected NIH3T3 cells from hydrogen-peroxide-induced cell death, prevented the hydrogen-peroxide-induced mitochondrial depolarization.
TIP47 is required for the production of infectious HIV-1 particles from primary macrophages.
GeneRIF
Berlioz-Torrent et al., Paris, France. In Traffic, 2010
TIP47 is required for the encounter between Gag and Env, and thus for the generation of infectious HIV-1 particles from primary macrophages.
Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization.
GeneRIF
Wolins et al., Saint Louis, United States. In J Biol Chem, 2009
Membrane-permeable diacylglycerols drive Perilipin 3 onto the endoplasmic reticulum.
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
Review
Welte et al., Houston, United States. In Biochim Biophys Acta, 2009
The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose differentiation-related protein (ADRP), tail-interacting protein of 47 kDa (TIP47), S3-12, and OXPAT.
Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage.
Review
Libien et al., New York City, United States. In Biochim Biophys Acta, 2009
Both adipocyte-differentiation related protein and TIP47 have been identified by immunohistochemical analysis to be present in HSC lipid droplets.
Fate of fat: the role of adipose triglyceride lipase in lipolysis.
Review
Zechner et al., Graz, Austria. In Biochim Biophys Acta, 2009
This led to the discovery of the perilipin, adipophilin, Tip47 (PAT) family of lipid droplet binding proteins and the identification of a novel TG hydrolase named adipose triglyceride lipase (ATGL).
RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport.
Impact
Pfeffer et al., Stanford, United States. In Cell, 2009
Because RhoBTB3 interacts with TIP47 on membranes, we propose that it may function to release this cargo selection protein from vesicles to permit their efficient docking and fusion at the Golgi.
Lipid droplets in lipogenesis and lipolysis.
Review
Bickel et al., Houston, United States. In Endocrinology, 2008
The coordination of lipid storage and utilization is regulated by the perilipin family of lipid droplet coat proteins [perilipin, adipophilin/adipocyte differentiation-related protein (ADRP), S3-12, tail-interacting protein of 47 kilodaltons (TIP47), and myocardial lipid droplet protein (MLDP)/oxidative tissues-enriched PAT protein (OXPAT)/lipid storage droplet protein 5 (LSDP5)].
In vitro selection and prediction of TIP47 protein-interaction interfaces.
Impact
Pfeffer et al., Stanford, United States. In Nat Methods, 2004
Tail-interacting protein of 47 kDa (TIP47) binds Rab9 GTPase and the cytoplasmic domains of mannose 6-phosphate receptors and is required for their transport from endosomes to the Golgi apparatus.
Role of Rab9 GTPase in facilitating receptor recruitment by TIP47.
Impact
Pfeffer et al., Stanford, United States. In Science, 2001
TIP47 recognizes the cytoplasmic domains of MPRs and is required for endosome-to-Golgi transport.
TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking.
Impact
Pfeffer et al., Stanford, United States. In Cell, 1998
We have identified a 47 kDa protein (TIP47) that binds selectively to the cytoplasmic domains of cation-independent and cation-dependent MPRs.
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