Deleted in breast cancer 1 plays a functional role in adipocyte differentiation.
Girona, Spain. In Am J Physiol Endocrinol Metab, May 2015
In both VAT and SAT, DBC1 mRNA levels were negatively associated with BMI and positively associated with age and the expression of PPARγ, GLUT4, IRS1, lipogenic (FASN, ACACA), lipid droplet-associated genes (PLIN1, FSP27, ADRP, and TIP47), and lipolytic (ABDH5, AKAP, and PRKACA) genes but negatively associated with ADIPOQ in VAT.
Lipid droplet associated proteins: an emerging role in atherogenesis.
Münster, Germany. In Histol Histopathol, 2011
However, only more recently has it become apparent that a special set of lipid droplet associated proteins - the PAT protein family (perilipin, adipophilin, TIP47, S3-12 and OXPAT) - is fundamental to the formation, growth, stabilization and functions of lipid droplets.