Three of a Kind: Genetically Similar Tsukamurella Phages TIN2, TIN3, and TIN4.
Bendigo, Australia. In Appl Environ Microbiol, Oct 2015
Three Tsukamurella phages, TIN2, TIN3, and TIN4, were isolated from activated sludge treatment plants located in Victoria, Australia, using conventional enrichment techniques.
Shelterin proteins and cancer.
Vellore, India. In Asian Pac J Cancer Prev, 2014
It comprises six proteins, namely TRF1, TRF2, TIN2, POT1, TPP1 and RAP1.
London, United Kingdom. In Hematology Am Soc Hematol Educ Program, 2010
Studies over the last 15 years have led to significant advances, with 8 DC genes (DKC1, TERC, TERT, NOP10, NHP2, TIN2, C16orf57, and TCAB1) having been characterized.
Seattle, United States. In Unknown Journal, 2009
To date, CTC1, DKC1, TERC, TERT, TINF2, NHP2, NOP10, and WRAP53 are the genes in which mutations are known to cause DC and result in very short telomeres.
Dyskeratosis congenita, stem cells and telomeres.
London, United Kingdom. In Biochim Biophys Acta, 2009
The products of these genes encode components that are critical for telomere maintenance; either because they are core constituents of telomerase (dyskerin, TERC, TERT, NOP10 and NHP2) or are part of the shelterin complex that protects the telomeric end (TIN2).
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
Houston, United States. In Nature, 2007
Additionally, the TEBP-alpha homologue, POT1, which binds telomeric single-stranded DNA (ssDNA), associates with multiple telomeric proteins (for example, TPP1, TIN2, TRF1, TRF2 and RAP1) to form the six-protein telosome/shelterin and other subcomplexes.
PTOP interacts with POT1 and regulates its localization to telomeres.
Houston, United States. In Nat Cell Biol, 2004
Telomere maintenance has been implicated in cancer and ageing, and requires cooperation between a multitude of telomeric factors, including telomerase, TRF1, TRF2, RAP1, TIN2, Tankyrase, PINX1 and POT1 (refs 1-12).
Regulation of telomerase by telomeric proteins.
New York City, United States. In Annu Rev Biochem, 2003
In addition, proteins that bind along the length of the telomere (TRF1/TIN2/tankyrase in humans and Rap1/Rif1/Rif2 in budding yeast) are part of a negative feedback loop that regulates telomere length.