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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TERF1

TIN2, TINF2
This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: TRF1, Thymopentin, TRF2, CLN2, Rap1
Papers on TIN2
Three of a Kind: Genetically Similar Tsukamurella Phages TIN2, TIN3, and TIN4.
New
Petrovski et al., Bendigo, Australia. In Appl Environ Microbiol, Oct 2015
Three Tsukamurella phages, TIN2, TIN3, and TIN4, were isolated from activated sludge treatment plants located in Victoria, Australia, using conventional enrichment techniques.
The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.
New
Xu et al., Davis, United States. In Plos Genet, Jul 2015
We have recapitulated the most common DC-causing mutation in the shelterin component TIN2 by introducing a TIN2-R282H mutation into cultured telomerase-positive human cells via a knock-in approach.
[Analysis of TERT and TIN2 Gene Expression in Patients with Acquired Aplastic Anemia and Their Correlation with Pathogenesis].
New
Luo et al., Jinan, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Jun 2015
OBJECTIVE: To detect the mRNA expression levels of TERT and TIN2 in peripheral blood mononuclear cells of acquired aplastic anemia(AAA) patients, and to explore their correlation with pathogenesis of acquired aplastic anemia.
Novel Mutation of the TINF2 Gene in a Patient with Dyskeratosis Congenita.
New
Limjindaporn et al., Bangkok, Thailand. In Case Rep Dermatol, May 2015
TINF2 encodes a protein in the shelterin complex and TERC encodes a component of the telomerase complex.
Shelterin proteins and cancer.
Review
Trivedi et al., Vellore, India. In Asian Pac J Cancer Prev, 2014
It comprises six proteins, namely TRF1, TRF2, TIN2, POT1, TPP1 and RAP1.
Characterization of the antioxidant systems in different complementation groups of Dyskeratosis Congenita.
Pallardo et al., Spain. In Free Radic Biol Med, 2014
The Telosoma comprises a network of protein (TRF2, TRF1, TIN2, RAP1, TPP1 and POT1).
The relationship between DNA methylation and telomere length in dyskeratosis congenita.
GeneRIF
Savage et al., Rockville, United States. In Aging Cell, 2012
The positive correlation between telomere length in dyskeratosis congenital and percent of LINE-1 methylation was restricted to TINF2 mutations.
TIN2 stability is regulated by the E3 ligase Siah2.
GeneRIF
Smith et al., New York City, United States. In Mol Cell Biol, 2012
Siah2 acts as an E3 ligase to directly ubiquitylate TIN2 in vitro.
Telomere protection by TPP1/POT1 requires tethering to TIN2.
GeneRIF
de Lange et al., New York City, United States. In Mol Cell, 2011
Telomere protection by TPP1/POT1 requires tethering to TIN2.
TIN2 protein dyskeratosis congenita missense mutants are defective in association with telomerase.
GeneRIF
Songyang et al., Houston, United States. In J Biol Chem, 2011
TIN2 mutations in DC may compromise the telomere recruitment of telomerase, leading to telomere shortening and the associated pathogenesis.
Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factors.
GeneRIF
Ly et al., Atlanta, United States. In Plos One, 2010
These results demonstrate the important roles that Sp1 and NF-kappaB play in regulating the expression of the human telomere-binding protein TIN2.
Dyskeratosis congenita.
Review
Dokal, London, United Kingdom. In Hematology Am Soc Hematol Educ Program, 2010
Studies over the last 15 years have led to significant advances, with 8 DC genes (DKC1, TERC, TERT, NOP10, NHP2, TIN2, C16orf57, and TCAB1) having been characterized.
The genetics and clinical manifestations of telomere biology disorders.
Review
Bertuch et al., Rockville, United States. In Genet Med, 2010
DKC1, TERC, TERT, NOP10, and NHP2 encode components of telomerase or a telomerase-associated factor and TINF2, a telomeric protein.
Dyskeratosis Congenita
Review
Savage, Seattle, United States. In Unknown Journal, 2009
To date, CTC1, DKC1, TERC, TERT, TINF2, NHP2, NOP10, and WRAP53 are the genes in which mutations are known to cause DC and result in very short telomeres.
Dyskeratosis congenita, stem cells and telomeres.
Review
Dokal et al., London, United Kingdom. In Biochim Biophys Acta, 2009
The products of these genes encode components that are critical for telomere maintenance; either because they are core constituents of telomerase (dyskerin, TERC, TERT, NOP10 and NHP2) or are part of the shelterin complex that protects the telomeric end (TIN2).
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Impact
Lei et al., Ann Arbor, United States. In Science, 2008
We dissect the interactions of TRF1 and TRF2 with their shared binding partner (TIN2) and other shelterin accessory factors.
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
Impact
Songyang et al., Houston, United States. In Nature, 2007
Additionally, the TEBP-alpha homologue, POT1, which binds telomeric single-stranded DNA (ssDNA), associates with multiple telomeric proteins (for example, TPP1, TIN2, TRF1, TRF2 and RAP1) to form the six-protein telosome/shelterin and other subcomplexes.
PTOP interacts with POT1 and regulates its localization to telomeres.
Impact
Songyang et al., Houston, United States. In Nat Cell Biol, 2004
Telomere maintenance has been implicated in cancer and ageing, and requires cooperation between a multitude of telomeric factors, including telomerase, TRF1, TRF2, RAP1, TIN2, Tankyrase, PINX1 and POT1 (refs 1-12).
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.
Impact
GeneRIF
de Lange et al., New York City, United States. In Nat Genet, 2004
Partial knockdown of TIN2 by small hairpin RNA in a telomerase-positive cell line resulted in telomere elongation, which is typical of reduced TRF1 function.
Regulation of telomerase by telomeric proteins.
Review
Impact
de Lange et al., New York City, United States. In Annu Rev Biochem, 2003
In addition, proteins that bind along the length of the telomere (TRF1/TIN2/tankyrase in humans and Rap1/Rif1/Rif2 in budding yeast) are part of a negative feedback loop that regulates telomere length.
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