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TIMP metallopeptidase inhibitor 4

TIMP-4, tissue inhibitor of metalloproteinase-4, tissue inhibitor of metalloproteinases-4
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MMP-9, MMP-2, TIMP-3, TIMP-2, HAD
Papers using TIMP-4 antibodies
ERbeta expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis
Supplier
Huang Chih-Yang et al., In Journal of Biomedical Science, 2009
... the following antibodies against JNK1/2, phospho-JNK1/2, uPA, tPA, PAI-1, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (Santa Cruz Biotechnology, Inc ...
Papers on TIMP-4
Human heart cell proteins interacting with a C-terminally truncated 2A protein of coxsackie B3 virus: identification by the yeast two-hybrid system.
New
Xia et al., Nanchang, China. In Virus Genes, Feb 2016
Choosing the 2A mutant with 17 aa deletion at the C-terminus as the bait protein, four interactive cellular proteins were identified, including TIMP4, MYL2, COX7C, and ENO1.
Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension.
New
Sigmund et al., Iowa City, United States. In Hypertension, Jan 2016
Gene expression profiling in aorta and mesenteric arteries revealed significantly decreased expression of tissue inhibitor of metalloproteinase-4 (TIMP-4) in S-P467L.
Inflammatory markers in pediatric stroke: An attempt to better understanding the pathophysiology.
New
Swiss Neuropediatric Stroke Registry Study Group et al., Canada. In Eur J Paediatr Neurol, Jan 2016
RESULTS: At the time of the acute event children with AIS had significantly elevated levels of MMP-9, TIMP4, IL-6, IL-8 and CRP compared to controls (p < 0.05).
Tissue inhibitor of metalloproteinases-4 (TIMP-4) regulates stemness in cervical cancer cells.
New
Melendez-Zajgla et al., Mexico. In Mol Carcinog, Dec 2015
UNASSIGNED: Tissue inhibitor of metalloproteinase-4 (TIMP-4) belongs to a family of extracellular matrix (ECM) metalloproteinases inhibitors that are overexpressed in several cancers.
Gene expression profiling of H9c2 cells subjected to H2O2-induced apoptosis with/without AF-HF001.
New
Feng et al., In Biol Pharm Bull, Dec 2015
Hierarchical clustering analysis revealed that AF-HF001 modifies the expression of certain genes (Ndufs2, Ndufb6, Ndufb8, Ndufa13, Ndufs3, Ndufs5, TPM1, MYH14, RyR1, and TIMP4) related to ROS production, cardiac contractility and extracellular matrix remodeling.
Correlation of Synovial Fluid Biomarkers With Cartilage Pathology and Associated Outcomes in Knee Arthroscopy.
New
Strauss et al., New York City, United States. In Arthroscopy, Nov 2015
The concentrations of the following 20 biomarkers were measured using a multiplex magnetic bead immunoassay: matrix metalloproteinase (MMP) 3; MMP-13; tissue inhibitor of metalloproteinase (TIMP) 1; TIMP-2; TIMP-3; TIMP-4; fibroblast growth factor 2; eotaxin; interferon γ; interleukin (IL) 10; platelet-derived growth factor BB; IL-1 receptor antagonist; IL-1β; IL-6; monocyte chemotactic protein 1 (MCP-1); macrophage inflammatory protein 1α; macrophage inflammatory protein 1β; RANTES (regulated upon activation, normal T cell expressed and secreted); tumor necrosis factor α; and vascular endothelial growth factor.
[Evaluation of tissue metaloproteinases inhibitors TIMP-2 and TIMP-4 in III-rd trimester of pregnancy].
New
Sikora-Szubert et al., In Ginekol Pol, Oct 2015
OBJECTIVES: Assessment of the concentrations soluble extracellular matrix metaloproteinases inhibitors TIMP-2 and TIMP-4 in blood of pregnant healthy women in III-rd trimester and in umbilical cord blood separately from arteries and umbilical cord vein.
[Expression and pathological mechanism of MMP-9 and HIF-2α in CD133(+) lung cancer stem cells].
New
Sun et al., Suzhou, China. In Zhonghua Yi Xue Za Zhi, Sep 2015
Real-time polymerase chain reaction (PCR) was used for the investigation of expression of tumor metastasis associated genes, including MMP-1, MMP-2, MMP-9, HIF-1α, HIF-1β, HIF-2α and tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, TIMP-3, TIMP-4.
TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients.
Cook et al., Australia. In Mol Vis, 2014
RESULTS: Concentrations of TIMP1 (p = 0.0008), TIMP2 (p = 0.002), TIMP4 (p = 0.002), and MMP2 (p = 0.020) were significantly increased in aqueous humor samples from POAG versus cataract samples.
Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm.
Dewald et al., Bonn, Germany. In Biomed Res Int, 2014
We found comparable collagen-stained area between the groups, significantly decreased mRNA level of CTGF, osteopontin-1, and MMP-2, and increased TIMP-4 expression in aneurysms.
Heterogeneity and degree of TIMP4, GATA4, SOX18, and EGFL7 gene promoter methylation in non-small cell lung cancer and surrounding tissues.
GeneRIF
Sverdlov et al., Moscow, Russia. In Cancer Genet, 2011
Heterogeneous methylation in the promoter region of TIMP4 was associated with cancer progression in non-small cell lung cancer.
Serum metalloproteinases MMP-2, MMP-9, and metalloproteinase tissue inhibitors in patients are associated with arteriovenous fistula maturation.
GeneRIF
Yuan et al., Sacramento, United States. In J Vasc Surg, 2011
A trend toward increased serum levels of MMP-9/TIMP-4 was found in patients with successful arteriovenous fistulas.
Plasma TIMP-4 predicts left ventricular remodeling after acute myocardial infarction.
GeneRIF
Ng et al., Glasgow, United Kingdom. In J Card Fail, 2011
Plasma TIMP-4 has a role in the prediction of LV remodeling and the pathophysiology of the heart postinfarction
Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi.
GeneRIF
Kingdom et al., Toronto, Canada. In Hum Reprod, 2011
TIMP4 expression is a downstream target of GCM1
TIMP-4 and CD63: new prognostic biomarkers in human astrocytomas.
GeneRIF
Salmon et al., Brussels, Belgium. In Mod Pathol, 2010
this work provides the first evidence of a TIMP-4/CD63 association in astrocytoma tumor cells
Role of metalloproteinases in platelet function.
Review
Radomski et al., Dublin, Ireland. In Thromb Res, 2007
Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP (MMP-14), ADAM-10, ADAM-17, ADAMTS-13, TIMP-1, TIMP-2 and TIMP-4.
Tissue inhibitor of metalloproteinases-4. The road less traveled.
Review
Maldonado et al., Mexico. In Mol Cancer, 2007
Recent evidence has shown that this family of four members (TIMP-1 to TIMP-4) can also control other important processes, such as proliferation and apoptosis, by a mechanism independent of their MMP inhibitory actions.
Intracellular targets of matrix metalloproteinase-2 in cardiac disease: rationale and therapeutic approaches.
Review
Impact
Schulz, Edmonton, Canada. In Annu Rev Pharmacol Toxicol, 2006
Oxidative stress activates full-length MMP-2 without need for proteolytic processing and inactivates an endogenous inhibitor, tissue inhibitor of metalloproteinase-4.
Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors.
Review
Brew et al., London, United Kingdom. In Biochem Soc Symp, 2002
Four related TIMPs (TIMP-1 to TIMP-4) can each form a complex with MMPs in a 1:1 stoichiometry with high affinity, but their inhibitory activities towards different MMPs are not particularly selective.
Tissue inhibitors of metalloproteinases and programmed cell death: conundrums, controversies and potential implications.
Review
Gazzanelli et al., Urbino, Italy. In Apoptosis, 2001
TIMP-4 plays a role in ECM homeostasis in a tissue-specific fashion and its overexpression induces PCD.
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