Cell-cycle arrest and acute kidney injury: the light and the dark sides.
Pittsburgh, United States. In Nephrol Dial Transplant, Jan 2016
We recently reported results from multi-center studies where two urinary markers of cell-cycle arrest, tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) were validated for development of AKI well ahead of clinical manifestations-azotemia and oliguria.
Inflammatory markers in pediatric stroke: An attempt to better understanding the pathophysiology.
Canada. In Eur J Paediatr Neurol, Jan 2016
Median levels of MMP-1, MMP-2, TIMP-1, TIMP-2, sE-selectin, sICAM-1, sVCAM-1, IL-8, IL-10, TNF-alpha, VEGF, Fetuin A were found to be higher in the neonatal group when compared with older children.
Biomarkers of drug-induced acute kidney injury in the adult.
Brisbane, Australia. In Expert Opin Drug Metab Toxicol, Nov 2015
Clinical biomarkers of cell cycle arrest, tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 show promise but need further validation in clinical trials.
Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis.
Nishinomiya, Japan. In J Pharmacol Sci, 2015
Cordycepin also showed an antimetastatic action through inhibiting platelet aggregation induced by cancer cells and suppressing the invasiveness of cancer cells via inhibiting the activity of matrix metalloproteinase (MMP)-2 and MMP-9, and accelerating the secretion of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 from cancer cells.
Three immunomarker support vector machines-based prognostic classifiers for stage IB non-small-cell lung cancer.
Guangzhou, China. In J Clin Oncol, 2009
The SVM2 model integrates age, cancer cell type, and 19 markers, including BCL2, caspase-9, CD34MVD, low-molecular-weight cytokeratin, high-molecular-weight cytokeratin, cyclo-oxygenase-2, EMA, HER2, matrix metalloproteinases (MMP) -2, MMP-9, p16, p21ras, p21WAF1, p27kip1, p53, TIMP-1, TIMP-2, vascular endothelial growth factor (VEGF), and beta-catenin.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression.
Sapporo, Japan. In J Clin Oncol, 2001
PATIENTS AND METHODS: Using immunohistochemistry, we analyzed 70 pancreatic ductal adenocarcinoma tissues for expression of MMP-1, MMP-2, MMP-3, MMP-7 (matrilysin), MMP-9, MT1-MMP, TIMP-1, and TIMP-2.