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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

TIM50 Tim50p

Tim50
Top mentioned proteins: V1a, Tim13, Tec, POLYMERASE, CAN
Papers on Tim50
Loss of TIM50 suppresses proliferation and induces apoptosis in breast cancer.
New
Jin et al., Shanghai, China. In Tumour Biol, Sep 2015
UNASSIGNED: TIM50 is an essential component of TIM23 complex and involved in protein translocating into the inner mitochondrial membrane.
Arabidopsis mitochondrial protein TIM50 affects hypocotyl cell elongation through intracellular ATP level.
Matsui et al., Yokohama, Japan. In Plant Sci, 2012
We have characterized a knockout mutant of the Arabidopsis TIM50 gene that showed a reduction in the hypocotyls length of etiolated seedlings.
Inner mitochondrial translocase Tim50 interacts with 3β-hydroxysteroid dehydrogenase type 2 to regulate adrenal and gonadal steroidogenesis.
GeneRIF
Bose et al., Savannah, United States. In J Biol Chem, 2011
Tim50 regulates 3betaHSD2 expression and activity, representing a new role for translocases in steroidogenesis.
Expression and structural characterization of human translocase of inner membrane of mitochondria Tim50.
GeneRIF
Li et al., Tianjin, China. In Protein Expr Purif, 2011
The far-UV CD spectra of Tim50(IMS) in native and denatured states revealed that the protein has a significantly folded secondary structure consisted of alpha-helixes and beta-sheets.
Structural basis for the function of Tim50 in the mitochondrial presequence translocase.
GeneRIF
Sha et al., Birmingham, United States. In J Mol Biol, 2011
The beta-hairpin is crucial for the interaction of Tim50 with Tim23, suggesting a cooperative function of these two essential TIM proteins in preprotein import.
Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance.
GeneRIF
Graves et al., Richmond, United States. In Arch Biochem Biophys, 2011
TIM50, was upregulated in a non-small cell lung carcinoma cell line (H1299) that expressed the p53 mutants R175H and R273H compared to cells lacking p53.
Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria.
GeneRIF
Neupert et al., München, Germany. In Mol Biol Cell, 2009
Tim50 and its association with TIM23 has a role in the transfer of protein precursors between the inner and outer mitochondrial membrane.
Involvement of the mitochondrial protein translocator component tim50 in growth, cell proliferation and the modulation of respiration in Drosophila.
Nishida et al., Nagoya, Japan. In Genetics, 2007
Molecular cloning identified the responsible gene as a budding yeast Tim50 ortholog, and thus it was named tiny tim 50 (ttm50).
A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction.
Whelan et al., Australia. In Plant Physiol, 2004
Mass spectrometric analysis of purified mitochondria identified 17 import components, their mitochondrial sub-compartment, and verified the presence of TIM8, TIM13, TIM17, TIM23, TIM44, TIM50, and METAXIN proteins for the first time, to our knowledge.
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