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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

T cell immunoglobulin and mucin domain containing 4

TIM-4, TIMD4
Top mentioned proteins: Tim-3, TH2, CAN, V1a, HAD
Papers on TIM-4
Expression of Tim4 in Glioma and its Regulatory Role in LN-18 Glioma Cells.
New
Zhang et al., Jinan, China. In Med Sci Monit, Dec 2015
BACKGROUND Tim4 is a transmembrane protein known as T cell immunoglobulin and mucin domain containing protein-4.
TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner.
New
Gao et al., Jinan, China. In Br J Cancer, Dec 2015
BACKGROUND: T-cell immunoglobulin domain and mucin domain 4 (TIM-4) is exclusively expressed in antigen-presenting cells and involved in immune regulation.
Differential Gene Expression Profiling of Orbital Adipose Tissue in Thyroid Orbitopathy.
New
Craig et al., Melbourne, Australia. In Invest Ophthalmol Vis Sci, Oct 2015
They include defensins (DEFA1, DEFA1B, DEFA3), which were overexpressed by 3.05- to 4.14-fold and TIMD4 by 4.20-fold.
Interaction of TIM4 and TIM3 induces T helper 1 cell apoptosis.
New
Yang et al., Shanghai, China. In Immunol Res, Oct 2015
This study aims to investigate the role of T cell immunoglobulin mucin domain molecule 4 (TIM4) in the induction of Th1 cell apoptosis.
Novel insights into Tim-4 function in autoimmune diseases.
Review
New
Ye et al., Hefei, China. In Autoimmunity, Jun 2015
T-cell immunoglobulin domain and mucin domain-4 (Tim-4) was first recognized as a costimulatory molecule regulating T-cell activation.
Characterization of Der f 29, a new allergen from dermatophagoides farinae.
Liu et al., Shenzhen, China. In Am J Transl Res, 2014
In addition, rDer f 29 induced bone marrow-derived dendritic cells (DC) to produce T cells immunoglobulin domain and mucin domain protein 4 (TIM4).
Tim-3 and Tim-4 as the potential targets for antitumor therapy.
Review
Ruan et al., Chongqing, China. In Hum Vaccin Immunother, 2014
Both Tim-3 and Tim-4 belong to the T-cell immunoglobulin and mucin domain (Tim) gene family, which plays a critical role in immunoregulation.
Genetic and environmental determinants of the susceptibility of Amerindian derived populations for having hypertriglyceridemia.
Review
Pajukanta et al., Mexico. In Metabolism, 2014
The same trend was observed for ANGPTL3 and TIMD4 variants.
Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread.
Impact
Brumell et al., Toronto, Canada. In Nature, 2014
The PS-binding receptor TIM-4 (encoded by the Timd4 gene) contributes to efficient cell-to-cell spread by L. monocytogenes in macrophages in vitro and growth of these bacteria is impaired in Timd4(-/-) mice.
TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.
Impact
Jinushi et al., Sapporo, Japan. In Immunity, 2014
In this study, we found that T cell immunoglobulin- and mucin domain-containing molecule-4 (TIM-4) repressed tumor-specific immunity triggered by chemotherapy-induced tumor cell death.
The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunity.
Review
Frieri et al., East Meadow, United States. In Allergy Asthma Proc, 2013
Tim-1-Tim-4 interaction promotes Th2 cytokine responses, and blocking this interaction can decrease airway inflammation in asthma and in allergic rhinitis.
Glioma-derived T cell immunoglobulin- and mucin domain-containing molecule-4 (TIM4) contributes to tumor tolerance.
GeneRIF
Liang et al., Chongqing, China. In J Biol Chem, 2011
macrophage-derived TIM4 plays an important role in the induction of Tregs in gliomas, which may play an important role in tumor tolerance.
The emerging role of the TIM molecules in transplantation.
Review
Najafian et al., Boston, United States. In Am J Transplant, 2011
The TIM family comprises of eight genes in the mouse, three of which are conserved in humans (TIM-1, TIM-3 and TIM-4).
The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury.
GeneRIF
Habicht et al., M√ľnchen, Germany. In J Am Soc Nephrol, 2011
The TIM-1:TIM-4 pathway enhances injury after renal ischemia-reperfusion injury and may be a therapeutic target.
Two polymorphisms in the TIM-4 gene are associated with asthma in a Chinese Han population.
GeneRIF
Liu et al., Jinan, China. In Int J Immunogenet, 2011
TIM-4 gene polymorphisms are associated with asthma in a Chinese Han population.
TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.
GeneRIF
DeKruyff et al., Boston, United States. In J Immunol, 2011
Overexpression of TIM-4 on antigen- presenting cells in transgenic mice reduces the number of antigen-specific T cells that remain after immunization, resulting in reduced secondary T cell responses.
The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms.
GeneRIF
Freeman et al., Boston, United States. In Hum Pathol, 2010
Histiocytic and dendritic cell neoplasms consistently express TIM-3 and TIM-4 and that these molecules are new markers of neoplasms derived from histiocytic and dendritic cells.
Common variants at 30 loci contribute to polygenic dyslipidemia.
Impact
Cupples et al., Boston, United States. In Nat Genet, 2009
The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP.
Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds.
Impact
GeneRIF
Casasnovas et al., Madrid, Spain. In Immunity, 2007
Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds.
Apoptotic PS to phagocyte TIM-4: eat me.
Impact
Gregory et al., Edinburgh, United Kingdom. In Immunity, 2007
Now cell and structural studies (Kobayashi et al. [2007] and Santiago et al. [2007] in this issue of Immunity) implicate the type I molecule TIM-4.
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