[Progress of molecular genetics research on rheumatoid arthritis].
Nanchong, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Oct 2015
In addition to genes from human leukocyte antigen (HLA) region, such as HLA-DRB, genes from non-HLA region, such as TIM-3, PTPN22, TRAF1/C5, STAT4, CCR5, PADI4 and FCGR2A may also contribute to its susceptibility.
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Boston, United States. In Nature, Feb 2015
T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viral infection and cancers.
Protective HIV-specific CD8+ T cells evade Treg cell suppression.
Seattle, United States. In Nat Med, 2011
This differential sensitivity of HIV-specific CD8(+) T cells to T(reg) cell-mediated suppression correlates with their expression of the inhibitory receptor T cell immunoglobulin domain and mucin domain 3 (Tim-3) after stimulation with their cognate epitopes.