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Tripartite motif containing 33

TIF1gamma, PTC7, TRIM33, RFG7
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Smad4, CAN, Ubiquitin, V1a, RET
Papers on TIF1gamma
Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.
New
Whitelaw et al., Melbourne, Australia. In Plos Genet, Dec 2015
A mutagenesis screen for modifiers of epigenetic gene silencing produced a line with a mutation in Trim33; the mutants displayed increased expression of the reporter transgene.
TIF1γ Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability.
New
Bartholin et al., Lyon, France. In Cancer Res, Nov 2015
The transcription accessory factor TIF1γ/TRIM33/RFG7/PTC7/Ectodermin functions as a tumor suppressor that promotes development and cellular differentiation.
Impact of Adenovirus E4-ORF3 Oligomerization and Protein Localization on Cellular Gene Expression.
New
Hearing et al., Stony Brook, United States. In Viruses, May 2015
Through the generation of knockdown cells, we demonstrate that the observed expression changes may be independent of Daxx and TRIM33 suggesting that an additional factor(s) may be responsible.
Type 2C protein phosphatase Ptc6 participates in activation of the Slt2-mediated cell wall integrity pathway in Saccharomyces cerevisiae.
New
Harashima et al., Suita, Japan. In J Biosci Bioeng, Apr 2015
The Saccharomyces cerevisiae genome encodes 40 PPases, including seven members of the protein phosphatase 2C subfamily (PTC1 to PTC7).
miR-629 Targets TRIM33 to Promote TGFβ/Smad Signaling and Metastatic Phenotypes in ccRCC.
New
Tsujikawa et al., Ōsaka, Japan. In Mol Cancer Res, Mar 2015
Mechanistically, miR-629 directly targeted tripartite motif-containing 33 (TRIM33), which inhibits the TGFβ/Smad signaling pathway.
Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development.
New
Kaartinen et al., Ann Arbor, United States. In Dev Biol, Mar 2015
Moreover, our results demonstrate that Trim33, a novel chromatin reader and regulator of TGF-β signaling, cooperates with Smad4 during palatogenesis.
The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer.
Vakoc et al., New York City, United States. In Elife, 2014
TRIM33 is identified here as a lineage dependency in B cell neoplasms and is shown to perform this essential function by associating with a single cis element.
TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation.
Romeo et al., Fontenay-aux-Roses, France. In Nat Commun, 2014
Here we report that TRIM33 deficiency results in high, sustained expression of Ifnb1 at late stages of toll-like receptor-mediated activation in macrophages but not in fibroblasts.
Tumour suppressor TRIM33 targets nuclear β-catenin degradation.
Huang et al., Houston, United States. In Nat Commun, 2014
Here we demonstrate that the tripartite motif-containing protein 33 (TRIM33), acting as an E3 ubiquitin ligase, reduces the abundance of nuclear β-catenin protein.
Quantification of pre-mRNA escape rate and synergy in splicing.
Becskei et al., Basel, Switzerland. In Nucleic Acids Res, 2014
We calculated the escape rate for the yeast PTC7 intron and pre-mRNA.
The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation.
Liu et al., Gaithersburg, United States. In J Immunol, 2014
In this study, we report that TRIM33, a member of the tripartite motif (TRIM) family, can bind DHX33 directly and induce DHX33 ubiquitination via the lysine 218 upon dsRNA stimulation.
Effects of deletion of different PP2C protein phosphatase genes on stress responses in Saccharomyces cerevisiae.
Harashima et al., Ōsaka, Japan. In Yeast, 2014
Saccharomyces cerevisiae has 40 PPases, including seven protein phosphatase 2C (PP2C PPase) genes (PTC1-PTC7).
Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.
GeneRIF
Bartholin et al., Lyon, France. In Am J Pathol, 2012
Tif1gamma suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.
Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection.
GeneRIF
Turnell et al., Birmingham, United Kingdom. In J Virol, 2012
Adenovirus E4orf3 targets TIF1 gamma for proteasome-dependent degradation during infection.
Adenovirus E4-ORF3-dependent relocalization of TIF1α and TIF1γ relies on access to the Coiled-Coil motif.
GeneRIF
Hearing et al., Stony Brook, United States. In Virology, 2012
These results suggest that E4-ORF3 targets proteins for relocalization through a loosely homologous sequence dependent on accessibility.
A poised chromatin platform for TGF-β access to master regulators.
Impact
GeneRIF
Massagué et al., New York City, United States. In Cell, 2012
Study reports an essential role for TRIM33 in the activation of Gsc and Mixl1 by nodal signals, and delineate how Smads gain access to poised promoters of master regulators under the command of nodal TGF-beta signals.
Dynamic regulation of Tgf-B signaling by Tif1γ: a computational approach.
GeneRIF
Théret et al., Rennes, France. In Plos One, 2011
Data suggest that the formation of transient TIF1gamma-Smad2-Smad4 ternary complexes is the only one that can account for TGF-beta signaling.
TIF1gamma controls erythroid cell fate by regulating transcription elongation.
Impact
GeneRIF
Zon et al., Boston, United States. In Cell, 2010
Chromatin immunoprecipitation assays in human CD34(+) cells supported a TIF1gamma-dependent recruitment of positive elongation factors to erythroid genes to promote transcription elongation by counteracting Pol II pausing.
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.
Impact
GeneRIF
Massagué et al., New York City, United States. In Cell, 2006
Thus, Smad2/3-TIF1gamma and Smad2/3-Smad4 function as complementary effector arms in the control of hematopoietic cell fate by the TGFbeta/Smad pathway.
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