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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TYRO3 protein tyrosine kinase

TIF, Byk, Tyro3, JDP2, dTK
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, ACID, HAD, AP-1
Papers using TIF antibodies
Mature olfactory receptor neurons express connexin43
Nagy James I. et al., In The Journal of Membrane Biology, 1999
... Fixed tissues were sliced to 150 μm thickness at 4 °C in a refrigerated vibrating microslicer (DTK-1000; Dosaka, Kyoto, Japan) or a Lancer Vibratome 3000 (Leica Microsystems, Buffalo Grove, IL), ...
Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway
Edgar Bruce A. et al., In The Journal of Cell Biology, 1999
... UAS–TIF-IA transgenic lines were generated by ...
Papers on TIF
Silencing of angiotensin II type-1 receptor inhibits high glucose-induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells via inactivation of mTOR/p70S6K signaling pathway.
Hou et al., Zhumadian, China. In Biochem Biophys Res Commun, Feb 2016
The epithelial-mesenchymal transition (EMT) plays a significant role in renal tubulointerstitial fibrosis (TIF), which is one of hallmark pathological feature of diabetic nephropathy (DN).
Tyro3 Modulates Mertk-Associated Retinal Degeneration.
LaVail et al., San Francisco, United States. In Plos Genet, Dec 2015
We genetically mapped the modifier to an approximately 2-megabase critical interval that includes Tyro3, a paralog of Mertk.
Host JDP2 expression in the bone marrow contributes to metastatic spread.
Aronheim et al., Haifa, Israel. In Oncotarget, Dec 2015
The c-Jun Dimerization Protein 2, JDP2, is a basic leucine zipper protein member of the activator protein-1 (AP-1) family of transcription factors.
LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions.
Zhou et al., Atlanta, United States. In Oncotarget, Nov 2015
Because half of RNA transcription in cancer is for pre-ribosomal RNA (rRNA) synthesis, which is suppressed by over 90% after AICAR treatment, we evaluated the role of TIF-IA-mediated rRNA synthesis.
Update on novel endoscopic therapies to treat gastroesophageal reflux disease: A review.
Karmali et al., Edmonton, Canada. In World J Gastrointest Endosc, Sep 2015
Long-term data suggests that transoral incisional fundoplication (TIF) with EsophyX may be effective for symptom control and proton pump inhibitor reduction or cessation for up to 2-6 years.
The oncogene c-Jun impedes somatic cell reprogramming.
Pei et al., Guangzhou, China. In Nat Cell Biol, Jul 2015
Furthermore, inhibition of c-Jun by shRNA, dominant-negative c-Jun or Jdp2 enhances reprogramming and replaces Oct4 among the Yamanaka factors.
Prognostic significance of macrophage invasion in hilar cholangiocarcinoma.
Jonas et al., Berlin, Germany. In Bmc Cancer, 2014
RESULTS: Patients with high density of TAMs in tumor invasive front (TIF) showed significantly higher local and overall tumor recurrence (both ρ < 0.05).
TAM receptor signaling in immune homeostasis.
Ghosh et al., In Annu Rev Immunol, 2014
The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation.
The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.
Earp et al., In Nat Rev Cancer, 2014
The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial malignancies.
The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene.
Davis, Charleston, United States. In Curr Alzheimer Res, 2014
In N2a cells, chromatin immunoprecipitation experiments revealed that a repressive complex forms at the AP-1 site in the human APP promoter, consisting of c-jun, c-jun dimerization protein 2 (JDP2) and HDAC3 and this complex was reduced in ABCA2 overexpressing cells.
Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood.
Tenstad et al., Bergen, Norway. In Bba Clin, 2014
BACKGROUND: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment.
Coactivator recruitment of AhR/ARNT1.
Shibasaki et al., Tokyo, Japan. In Int J Mol Sci, 2013
Based on these data, we suggest a newly derived tentative binding site of nuclear coactivator 2/glucocorticoid receptor interacting protein-1/transcriptional intermediary factor 2 (NCOA-2/ GRIP-1/TIF-2) for ARNT1.1 exon 16.
The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.
Akira et al., Ōsaka, Japan. In Immunity, 2013
Jdp2 is an AP-1 family transcription factor that regulates the epigenetic status of histones.
Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.
Kawaoka et al., Tokyo, Japan. In J Virol, 2012
Axl,Tyro3,DC-SIGN and LSECtin are identified as new virus receptors for Lassa virus cell entry.
Novel and selective spiroindoline-based inhibitors of Sky kinase.
Perrin et al., Ann Arbor, United States. In Bioorg Med Chem Lett, 2012
analysis of novel and selective spiroindoline-based inhibitors of Sky kinase
Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.
Prieto et al., Bloomington, United States. In Plos One, 2011
Overexpression of Tyro3 in the Rat2 cell line that expresses Axl, but not Mer or Tyro3, resulted in a 5 fold increase in cell proliferation.
Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and β-amyloid deposition in Alzheimer's disease models.
Wang et al., Beijing, China. In Plos One, 2011
Receptor tyrosine kinase Tyro3 is involved in amyloidogenic Amyloid beta-Protein Precursor processing and beta-amyloid deposition in Alzheimer's disease models.
Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency.
Tsurumi et al., Nagoya, Japan. In J Biol Chem, 2011
JDP2 is crucial to triggering reactivation from latency to lytic replication
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Feinberg et al., Baltimore, United States. In Nature, 2010
Many examples of genes and pathways not previously known to be involved in choice between lymphoid/myeloid differentiation have been identified, such as Arl4c and Jdp2.
Viprakasit et al., Nicosia, Cyprus. In Unknown Journal, 0001
Throughout the past four years, six major TDT management guidelines became available for use by thalassaemia care givers (TIF, US, Canadian, UK, Italian and Australian Guidelines).
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