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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Kruppel-like factor 10

TIEG, TIEG1, KLF10
Kruppel-like zinc finger transcription factor; involved in TGFbeta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: TGF-beta, SP1, CAN, V1a, KLF11
Papers on TIEG
Chronic methamphetamine treatment reduces the expression of synaptic plasticity genes and changes their DNA methylation status in the mouse brain.
New
Chen et al., Taipei, Taiwan. In Brain Res, Jan 2016
We detected six downregulated genes in the frontal cortex and the hippocampus of chronic METH-treated mice, including five IEGs (Arc, Egr2, Fos, Klf10, and Nr4a1) and one neuronal receptor gene (Grm1), compared with normal saline-treated group, but only four genes (Arc, Egr2, Fos, and Nr4a1) were confirmed to be different.
Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation.
New
Faubion et al., Rochester, United States. In Am J Physiol Gastrointest Liver Physiol, Jan 2016
In the present study, we demonstrate a novel role for KLF10 in the regulation of TGFβRII expression with functional relevance in macrophage differentiation and activation.
C2H2 zinc finger proteins of the SP/KLF, Wilms tumor, EGR, Huckebein, and Klumpfuss families in metazoans and beyond.
New
Grishin et al., Dallas, United States. In Gene, Dec 2015
The last ancestor of jawed vertebrates was inferred to have at least 18 KLFs (group A: KLF1/2/4/17, group B: KLF3/8/12; group C: KLF5/5l; group D: KLF6/7; group E: KLF9/13/16; group F: KLF10/KLF11; group G: KLF15/15l) and 10 SPs (group A: SP1/2/3/4; group B: SP5/5l; group C: SP6/7/8/9), since they were found in both cartilaginous and boned fishes.
Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes.
New
Chen et al., Hangzhou, China. In Cell Tissue Res, Sep 2015
UNASSIGNED: Klf10, a member of the Krüppel-like family of transcription factors, is critical for osteoblast differentiation, bone formation and mineralization.
TIEG1 Inhibits Angiotensin II-induced Cardiomyocyte Hypertrophy by Inhibiting Transcription Factor GATA4.
New
Liu et al., Guangzhou, China. In J Cardiovasc Pharmacol, Aug 2015
The transforming growth factor (TGF-β)-inducible early gene (TIEG1), a member of the Sp1/Krüppel-like family of transcription factors, plays an important role in regulating cell growth, differentiation, and apoptosis in many human diseases, including breast cancer, osteoporosis, and atherosclerosis.
CDK2 phosphorylation regulates the protein stability of KLF10 by interfering with binding of the E3 ligase SIAH1.
New
Yu et al., Taipei, Taiwan. In Biochim Biophys Acta, May 2015
It is known that KLF10 mimics the anti-proliferative and apoptotic effects that TGF-β1 has on epithelial cell growth and the growth of various tumor cells; based on these findings it is considered as a tumor suppressor.
Krüppel-like factor 10 null mice exhibit lower tumor incidence and suppressed cellular proliferation activity following chemically induced liver tumorigenesis.
New
Choi et al., Seoul, South Korea. In Oncol Rep, Apr 2015
One of these pathways, the transforming growth factor-β (TGF-β)/Smad pathway with KLF10, has been reported to suppress cellular proliferation in most cases.
Identification of new susceptibility loci for IgA nephropathy in Han Chinese.
Liu et al., Guangzhou, China. In Nat Commun, 2014
(rs2074038, OR=1.14, P=3.93 × 10(-9)) and ODF1-KLF10 on 8q22.3 (rs2033562, OR=1.13,
Effect of TIEG1 on apoptosis and expression of Bcl-2/Bax and Pten in leukemic cell lines.
Liu et al., Shenyang, China. In Genet Mol Res, 2014
We examined the effect of transforming growth factor-b inducible early gene-1 (TIEG1) on the apoptosis of leukemic cell lines and expression of B-cell lymphoma 2 (Bcl-2) and phosphatase and tensin homolog (Pten).
TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy.
GeneRIF
Ackerman et al., Rochester, United States. In J Cell Biochem, 2012
study identified 6 novel, hypertrophic cardiomyopathy associated TIEG1 missense variants and have demonstrated that a number of these variants have abnormal function with regard to mutant TIEG1's ability to regulate either the PTTG1 or SMAD7 promoters
KLF10, transforming growth factor-β-inducible early gene 1, acts as a tumor suppressor.
GeneRIF
Lee et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
This study demonstrates that KLF10 is a tumor suppressor and that it targets p21(WAF1/CIP1) transcription.
Impaired cutaneous wound healing in transforming growth factor-β inducible early gene1 knockout mice.
GeneRIF
Tredget et al., Edmonton, Canada. In Wound Repair Regen, 2012
TIEG1 knockout (TIEG1-/-) mice have a delay in wound closure related to an impairment in wound contraction, granulation tissue formation, collagen synthesis, and reepithelialization.
TIEG1 inhibits breast cancer invasion and metastasis by inhibition of epidermal growth factor receptor (EGFR) transcription and the EGFR signaling pathway.
GeneRIF
Shao et al., Shanghai, China. In Mol Cell Biol, 2012
Tieg1 suppresses mammary tumorigenesis in xenografts in mice, and decreases lung metastasis by inhibition of Egfr gene transcription and the Egfr signaling pathway.
Klf10 and Klf11 as mediators of TGF-beta superfamily signaling.
Review
Krieglstein et al., Freiburg, Germany. In Cell Tissue Res, 2012
Klf10 and Klf11 belong to the family of Sp1/Krüppel-like zinc finger transcription factors that play important roles in a variety of cell types and tissues.
Associations between lipid metabolism and fertility in the dairy cow.
Review
Pollott et al., United Kingdom. In Reprod Fertil Dev, 2011
The expression of genes involved in insulin resistance (PDK4, AHSG) is increased, together with expression of TIEG1, a transcription factor that can induce apoptosis via the mitochondrial pathway.
Krüppel-like factor-10 is directly regulated by carbohydrate response element-binding protein in rat primary hepatocytes.
GeneRIF
Horikawa et al., Gifu, Japan. In Biochem Biophys Res Commun, 2011
these data suggest that crosstalk between ChREBP and KLF-10 is involved in the regulation of the lipogenic pathway.
Tapping the brake on cardiac growth-endogenous repressors of hypertrophic signaling.
Review
Creemers et al., Amsterdam, Netherlands. In J Mol Cell Cardiol, 2011
In addition, we will focus on factors such as Kruppel-like factors (KLF4, KLF15 and KLF10) and histone deacetylases (HDACs), which constitute a relevant group of nuclear proteins that repress transcription of the hypertrophic gene program in cardiomyocytes.
Functional role of KLF10 in multiple disease processes.
Review
GeneRIF
Spelsberg et al., Rochester, United States. In Biofactors, 2010
KLF10 has been shown to play a major role in the TGFbeta inhibition of cell proliferation and inflammation and induction of apoptosis, and its overexpression in human osteoblasts and pancreatic carcinoma cells mimics the actions of TGFbeta[review]
TGFbeta regulated gene expression by Smads and Sp1/KLF-like transcription factors in cancer.
Review
Ellenrieder, Marburg an der Lahn, Germany. In Anticancer Res, 2008
These studies have led to the identification of a novel family of TGFbeta-inducible Sp1/KLF-(Krüppel-like factors) like transcription factors (KLF10 and KLF11) which play remarkable roles in TGFbeta mediated cell growth control and differentiation.
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1.
Impact
Liu et al., Los Angeles, United States. In Nat Immunol, 2008
The E3 ubiquitin ligase Itch associated with and promoted conjugation of ubiquitin to the transcription factor TIEG1. Itch cooperated with TIEG1 to induce Foxp3 expression, which was reversed by TIEG1 deficiency.
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