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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

TEK tyrosine kinase, endothelial

TIE-2, Tek
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Angpt1, vascular endothelial growth factor, KDR, CAN, HAD
Papers using TIE-2 antibodies
Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype
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Clarkson B et al., In Blood Cancer Journal, 2008
... Anti-CD117, c-kitR (clone 104D2); CD123, α-chain of IL-3 receptor (clone 6H6); CD202b (Tie2; clone 33.1; Biolegend); CD33 (clone 906) and ...
Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface
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Brindle Nicholas P.J. et al., In Cellular Signalling, 2007
... Antibodies recognizing Tie2 extracellular domain were obtained from R & D Systems and those recognizing Tie1 and Tie2 intracellular domains and phosphotyrosine were from Santa Cruz Biotechnology (from Autogen Bioclear, Calne, ...
Protein-protein interaction analysis by C-terminally specific fluorescence labeling and fluorescence cross-correlation spectroscopy.
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Cai Huaibin, In PLoS ONE, 2005
... HeLa cells grown on LAB-TEK chambered coverslips with eight wells (Nalge Nunc International, Naperville, IL, USA) were transfected using Effectene Transfection Reagent (Qiagen, Valencia, CA, USA) ...
Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation.
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Kirchmair Rudolf, In PLoS ONE, 2004
... Anti-Tie2 monoclonal, anti-LRP5, -β-catenin, -AQ5, β-GAL polyclonal antibodies were from Abcam.
Development of structures and transport functions in the mouse placenta
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Guan Jun-Lin et al., In The Journal of Cell Biology, 2004
... Tie2-Cre transgenic mice and CFKO mice ...
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Papers on TIE-2
A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis.
New
Littlewood-Evans et al., Basel, Switzerland. In J Med Chem, Feb 2016
They potently inhibit VEGF-driven angiogenesis in a chamber model and rodent tumor models at daily doses of less than 3 mg/kg by targeting the tumor vasculature as demonstrated by ELISA for TIE-2 in lysates or by immunohistochemical analysis.
The safety of regorafenib for the treatment of gastrointestinal stromal tumors.
New
Stępniak et al., Warsaw, Poland. In Expert Opin Drug Saf, Jan 2016
AREAS COVERED: Regorafenib, an oral multitargeted inhibitor with activity against multiple kinases including KIT, RET, RAF1, BRAF, angiogenesis (VEGFR, TIE-2) and those involved in tumor microenvironment (PDGFR and FGFR) was introduced after the successful Phase III GRID (GIST - Regorafenib In progressive Disease) clinical trial.
Somatic Activating PIK3CA Mutations Cause Venous Malformation.
New
Vikkula et al., Brussels, Belgium. In Am J Hum Genet, Jan 2016
Somatic mutations in TEK, the gene encoding endothelial cell tyrosine kinase receptor TIE2, cause more than half of sporadically occurring unifocal venous malformations (VMs).
Changes in plasma biomarkers following treatment with cabozantinib in metastatic castration-resistant prostate cancer: a post hoc analysis of an extension cohort of a phase II trial.
New
Joshua et al., Israel. In J Transl Med, Dec 2015
The plasma concentrations of VEGFR2, Trap5b, Angiopoietin-2, TIMP-2 and TIE-2 significantly decreased during treatment with caboznatinib.
Current trends and recent advances in diagnosis, therapy, and prevention of hepatocellular carcinoma.
Review
Kuo et al., Tainan City, Taiwan. In Asian Pac J Cancer Prev, 2014
Based on in-depth reviews of serological diagnosis of HCC, in addition to AFP, there are other biomarkers: Lens culinaris agglutinin-reactive AFP (AFP-L3), des- carboxyprothrombin (DCP), tyrosine kinase with Ig and eprdermal growth factor (EGF) homology domains 2 (TIE2)-espressing monocytes (TEMs), glypican-3 (GPC3), Golgi protein 73 (GP73), interleukin-6 (IL-6), and squamous cell carcinoma antigen (SCCA) have been proposed as biomarkers for the early detection of HCC.
Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin.
Shibuya et al., Tsukuba, Japan. In Plos One, 2014
We found that Tek, which encodes Tie2, was preferentially expressed in the MCs of both humans and mice.
Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance.
Impact
Katze et al., Seattle, United States. In Science, 2014
Inflammatory signaling was associated with vascular permeability and endothelial activation, and resistance to lethal infection arose by induction of lymphocyte differentiation and cellular adhesion, probably mediated by the susceptibility allele Tek.
Dermatological toxicity associated with targeted therapies in cancer: optimal management.
Review
Dréno et al., Nantes, France. In Am J Clin Dermatol, 2014
They target pathways involved in signal transduction (EGFR, HER2, HER3, HER4, FLT3, RAS, RAF, MEK, KIT, RET, mTOR, SRC, EPH, SCF), tumor angiogenesis (VEGFR, TIE2), and tumor microenvironment (PDGFR, FGFR).
Regorafenib.
Review
Seufferlein et al., Ulm, Germany. In Recent Results Cancer Res, 2013
Regorafenib (BAY 73-4506, Stivarga®) is an oral diphenylurea multikinase inhibitor that targets angiogenic (VEGFR1-3, TIE2), stromal (PDGFR-β, FGFR), and oncogenic receptor tyrosine kinases (KIT, RET, and RAF).
Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis.
Review
Kzhyshkowska et al., Mannheim, Germany. In Front Physiol, 2013
Tumor endothelium releases angiopoietin-2 and further facilitates recruitment of TIE2 receptor expressing monocytes (TEM) into tumor sites.
Epidermal growth factor regulates hematopoietic regeneration after radiation injury.
Impact
Chute et al., Durham, United States. In Nat Med, 2013
We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow serum of mice bearing deletion of Bak and Bax in TIE2-expressing cells in Tie2Cre; Bak1(-/-); Bax(flox/-) mice.
Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma.
Impact
Srinivasan et al., Boston, United States. In J Clin Oncol, 2013
PURPOSE: Foretinib is an oral multikinase inhibitor targeting MET, VEGF, RON, AXL, and TIE-2 receptors.
Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: a single-group phase 2 trial.
Impact
Quinn et al., Cambridge, United Kingdom. In Lancet Oncol, 2012
Regorafenib also inhibits other potentially important angiogenic kinases like TIE2, activation of which is thought to be important in tumour escape mechanisms.
Decreased soluble TGF-β1, Tie-2, and angiopoietins serum levels in bone marrow after treating healthy donors with granulocyte colony-stimulating factor.
GeneRIF
Sun et al., Shijiazhuang, China. In Transfus Apher Sci, 2012
Decreased soluble TGF-beta1, Tie-2, and angiopoietins serum levels in bone marrow after treating healthy donors with granulocyte colony-stimulating factor.
Tie2-dependent knockout of α6 integrin subunit in mice reduces post-ischaemic angiogenesis.
GeneRIF
Helley et al., Paris, France. In Cardiovasc Res, 2012
Examination of the ischaemic muscles showed that Tie2-dependent alpha6 deletion decreased the recruitment of pro-angiogenic Tie2-expressing macrophages
Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome.
GeneRIF
Tesone et al., Buenos Aires, Argentina. In Endocrinology, 2012
Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome
Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling.
GeneRIF
Augustin et al., Heidelberg, Germany. In J Clin Invest, 2012
a contextual model whereby differential TIE2 and integrin expression, binding, and activation control the role of ANG-2 in angiogenesis.
Cutaneomucosal venous malformations are linked to the TIE2 mutation in a large Chinese family.
GeneRIF
Yuan et al., In Exp Dermatol, 2012
The R849W mutation in TIE2 could be one of the major causes for cutaneomucosal venous malformations in Asian families.
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Impact
Lyden et al., New York City, United States. In Nat Med, 2012
Melanoma-derived exosomes also induced vascular leakiness at pre-metastatic sites and reprogrammed bone marrow progenitors toward a pro-vasculogenic phenotype that was positive for c-Kit, the receptor tyrosine kinase Tie2 and Met.
Role of angiopoietin/tie2 in critical illness: promising biomarker, disease mediator, and therapeutic target?
Review
David et al., Hannover, Germany. In Scientifica (cairo), 2011
The angiopoietin (Angpt)/Tie2 system consists of the endothelial tyrosine kinase Tie2 and its 4 circulating ligands (Angpt1-4).
More papers using TIE-2 antibodies
Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction
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Paleolog Ewa M et al., In Arthritis Research & Therapy, 2004
... Anti-human Tie1 (C18) and Tie2 (C-20) rabbit polyclonal antibodies specific to the C-terminal receptor domains were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy.
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Navarro Alfons, In PLoS ONE, 2003
... Tie2-GFP transgenic mice using a previously described ...
Locus-specific and activity-independent gene repositioning during early tumorigenesis
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Misteli Tom et al., In The Journal of Cell Biology, 2003
... For 3D culture, 5,000 cells were seeded per well into a Laboratory-Tek 8-chambered glass slide (Thermo Fisher Scientific) that had been coated with thin layer of reduced growth factor reconstituted basement membrane extract (rBME; Trevigen), and were maintained in ...
Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse
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Engelhardt Britta et al., In Acta Neuropathologica, 2000
... Construction of the Tie-2 tTA vector and production of transgenic mice was described elsewhere ...
β-Catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse
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Dejana Elisabetta et al., In The Journal of Cell Biology, 1999
... The Tie2-Cre transgenic mice were a gift of ...
The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility
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Dejana Elisabetta et al., In The Journal of Cell Biology, 1999
... Tie2-Cre transgenic mice were a gift of ...
Real-time PCR quantification of full-length and exon 11 spliced BRCA1 transcripts in human breast cancer cell lines.
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Koch Alisa E et al., In Arthritis Research, 1999
... The polyclonal antibodies, goat antihuman Ang-1 and Ang-2, and rabbit antihuman Tie1 and Tie2, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation
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Wang Rong et al., In The Journal of Cell Biology, 1997
... Tie2-Cre transgenic (Tg) mice followed a previously ...
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
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Guan Jun-Lin et al., In The Journal of Cell Biology, 1997
... EIIa-Cre transgenic mice were obtained from Jackson Laboratory and Tie2-Cre transgenic mice have been described ...
Endothelial Cells Require STAT3 for Protection against Endotoxin-induced Inf lammation
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Fu Xin-Yuan et al., In The Journal of Experimental Medicine, 1996
... Two Tie2-Cre transgenic mouse strains expressing Cre ...
The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work
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McAinsh Andrew D. et al., In The Journal of Cell Biology, 1995
... Live cell imaging experiments were performed in chambers (Lab-Tek II; Thermo Fisher Scientific) with Leibovitz L-15 medium (Invitrogen) + 10% FCS at 37°C.siRNA oligonucleotides (siControl; Allstar; QIAGEN), Nuf2R ( ...
The pathophysiology of anti-neutrophil cytoplasmic antibodies (ANCA) and their clinical relevance.
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Mayet Werner et al., In Arthritis Research, 1995
... Tissue samples were snap-frozen in OCT Tissue Tek embedding medium (Leica Instruments, Hamburg, Germany).
Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein
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Sugden Peter H. et al., In The Journal of Cell Biology, 1994
... Lab-Tek tissue culture chamber slides were from Life Technologies (Paisley, Scotland, UK) ...
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