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RAD54 homolog B

TID1, RDH54, RAD54B, hTid-1
The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RAD54, Rad51, CAN, RAD52, BRG1
Papers using TID1 antibodies
Altered synchrony and connectivity in neuronal networks expressing an autism-related mutation of neuroligin 3.
Cookson Mark R., In PLoS ONE, 2008
... Anti-Rdj2 mouse monoclonal and anti-DnaJA3 (Tid1) polyclonal antibody were from Abnova.
Papers on TID1
High reactive oxygen species levels are detected at the end of the chronological life span of translocant yeast cells.
Tosato et al., Trieste, Italy. In Mol Genet Genomics, Oct 2015
Additionally, the RDH54 gene may play a role in the correct segregation of the translocant chromosome, since in its absence there is an increase in loss of the bridge-induced translocated chromosome.
High RAD54B expression: an independent predictor of postoperative distant recurrence in colorectal cancer patients.
Watanabe et al., Tokyo, Japan. In Oncotarget, Sep 2015
We recently reported a specific mechanism that RAD54B, an important factor in homologous recombination, promotes genomic instability via the degradation of p53 protein in vitro.
Genomic Study of Cardiovascular Continuum Comorbidity.
Puzyrev et al., Tomsk, Russia. In Acta Naturae, Jul 2015
A total of 14 genetic variants were associated with a combination of several diseases of cardiovascular continuum (CVC), including those in the TAS2R38, SEZ6L, APOA2, KLF7, CETP, ITGA4, RAD54B, LDLR, and MTAP genes, along with intragenic variants rs1333048, rs1333049, and rs6501455.
Cell cycle regulation of human DNA repair and chromatin remodeling genes.
Krokan et al., Trondheim, Norway. In Dna Repair (amst), Jun 2015
genes for chromatin assembly factor 1 (CAF-1) major subunits CHAF1A and CHAF1B; the putative helicases HELLS and ATAD2 that both co-activate E2F transcription factors central in G1/S-transition and recruit DNA repair and chromatin-modifying proteins and DNA double strand break repair proteins; and RAD54L and RAD54B involved in double strand break repair.
RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.
Bishop et al., Chicago, United States. In Nucleic Acids Res, May 2015
We further show that combined depletion of RAD54L and RAD54B and/or artificial induction of RAD51 overexpression blocks replication and promotes chromosome segregation defects.
DNA Double Strand Break Response and Limited Repair Capacity in Mouse Elongated Spermatids.
de Rooij et al., Asyūţ, Egypt. In Int J Mol Sci, 2014
This technique enabled us to determine the background level of DSB foci in elongated spermatids of RAD54/RAD54B double knockout (dko) mice, severe combined immunodeficiency SCID mice, and poly adenosine diphosphate (ADP)-ribose polymerase 1 (PARP1) inhibitor (DPQ)-treated mice to compare them with the appropriate wild type controls.
The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma.
Liu et al., Kao-hsiung, Taiwan. In Plos One, 2014
Among 24 paired genes, only FEN1 (Flap endonuclease 1) and RAD54B (RAD54 homolog B) were overexpressed in lung adenocarcinoma patients with poor prognosis.
The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.
Connell et al., Chicago, United States. In Cancer Res, 2014
Resistance to RS-1 tended to occur in cells with higher levels of RAD54L and RAD54B, which are Swi2/Snf2-related translocases known to dissociate RAD51 filaments from dsDNA.
Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength.
Miyagawa et al., Tokyo, Japan. In Nat Commun, 2013
Here we show that Rad54B--a SNF2 helicase-like DNA-repair protein--limits the strength of both the G1/S and G2/M checkpoints.
Differential expression of DNA repair genes in Hispanic women with breast cancer.
Suarez et al., Ponce, Puerto Rico. In Mol Cancer Biol, 2013
Those candidate genes were CHEK2, EME1 (MMS4L), ERCC3 (XPB), FANCM, H2AFX (H2AX), HMGB1, HUS1, MBD4, NEIL3, PCNA, RAD1, RAD23B, RAD51, RAD54B, RDM1 (RAD52B), SHFM1 (DSS1), TP1, UBE2N (UBC13) and XRCC5 (Ku80).
Saccharomyces cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins, respectively, to promote DNA strand invasion during genetic recombination.
Kowalczykowski et al., Davis, United States. In J Biol Chem, 2012
Rad51-Rad54 function together to promote intersister DNA strand exchange, whereas Dmc1-Tid1 tilt the bias toward interhomolog DNA strand exchange.
Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentation.
Kim et al., Calgary, Canada. In Int J Biochem Cell Biol, 2012
Data show that elevated DnaJA3 induces dynamin-related protein 1 (Drp1)-depedendent mitochondrial fragmentation and decreased cell viability.
Absence of a human DnaJ protein hTid-1S correlates with aberrant actin cytoskeleton organization in lesional psoriatic skin.
Joe et al., Taejŏn, South Korea. In J Biol Chem, 2012
loss of hTid-1(S) expression in the basal layer of skin epidermis correlates with the enhanced HSP27 phosphorylation, keratinocyte hyperproliferation, and excess actin cytoskeleton organization in lesional psoriatic skin
Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients.
Lo et al., Taipei, Taiwan. In J Pathol, 2011
Tid1 and CHIP play pivotal roles in affecting the levels of ErbB2 protein, and that both are significant prognostic indicators of breast cancer patient survival.
Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease.
Braun et al., Calgary, Canada. In Plos One, 2010
changes in cellular TID1 are a factor in the pathogenesis of Parkinson's disease
Meiosis and small ubiquitin-related modifier (SUMO)-conjugating enzyme, Ubc9.
Iwabata et al., Noda, Japan. In Febs J, 2007
After CcLim15-CcTopII dissociation, CcLim15 remains on the zygotene DNA and recruits CcUbc9, Rad54B, CcUbc9, Swi5-Sfr1, CcUbc9 and then CcPCNA in rotation on the C-terminus.
Evaluating HapMap SNP data transferability in a large-scale genotyping project involving 175 cancer-associated genes.
Benítez et al., Madrid, Spain. In Hum Genet, 2006
We found that of the 21 genes that contained at least one block larger than 60 kb, nine (ATM, ATR, BRCA1, ERCC6, FANCC, RAD17, RAD50, RAD54B and XRCC4) belonged to the GO category "DNA repair".
Recombination proteins in yeast.
Symington et al., New York City, United States. In Annu Rev Genet, 2003
Central to the process of homologous recombination are the RAD52 group genes (RAD50, RAD51, RAD52, RAD54, RDH54/TID1, RAD55, RAD57, RAD59, MRE11, and XRS2), most of which were identified by their requirement for the repair of ionizing radiation-induced DNA damage in Saccharomyces cerevisiae.
Homologous recombinational repair proteins in mouse meiosis.
Schimenti et al., Bar Harbor, United States. In Cytogenet Genome Res, 2003
In this review, we discuss primarily those proteins involved in the initial stages of homologous recombination, including SPO11, MRE11, RAD50, NBS1, DMC1, RAD51, RAD51 paralogs, RAD52, RPA, RAD54, and RAD54B.
Plasma membrane rafts and chaperones in cytokine/STAT signaling.
Sehgal, Valhalla, United States. In Acta Biochim Pol, 2002
These chaperones include the human homolog of the tumorous imaginal disc 1 protein (hTid1) which associates with Janus kinase 2 (JAK2) at the level of the plasma membrane, heat shock protein 90 (HSP90) which associates with STAT3 and STAT1 proteins in caveolin-1-containing raft and cytoplasmic complexes, and glucose regulated protein 58 (GRP58/ER-60/ERp57), a thiol dependent protein-disulfide isomerase, found in association with STAT3 "statosome" complexes in the cytosol and in the raft fraction.
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