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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Aryl hydrocarbon receptor nuclear translocator-like

Tic, BMAL1
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CLOCK, CAN, period 2, CRY1, V1a
Papers on Tic
Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.
New
Xu et al., Nanjing, China. In Cell Rep, Feb 2016
UNASSIGNED: In the core mammalian circadian negative feedback loop, the BMAL1-CLOCK complex activates the transcription of the genes Period (Per) and Cryptochrome (Cry).
NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.
New
Impact
Machida et al., Los Angeles, United States. In Cell Metab, Feb 2016
NANOG represses mitochondrial oxidative phosphorylation (OXPHOS) genes, as well as ROS generation, and activates fatty acid oxidation (FAO) to support TIC self-renewal and drug resistance.
Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype.
New
Kondratov et al., Cleveland, United States. In Bone, Feb 2016
The transcription factor Brain and Muscle ARNT-like Protein 1 (BMAL1) is a component of the circadian clock and necessary for clock function.
Characterization of B-Cells in tonsils of patients diagnosed with pediatric autoimmune neuropsychiatric disorder associated streptococcus.
New
Harley et al., Washington, D.C., United States. In Int J Pediatr Otorhinolaryngol, Jan 2016
In addition, we must investigate if PANDAS patients only demonstrate increased B-Cell number or activity when undergoing an acute Tic/OCD exacerbation.
The emerging roles of Oct4 in tumor-initiating cells.
Review
New
Herlyn et al., Hangzhou, China. In Am J Physiol Cell Physiol, Jan 2016
There is circumstantial evidence for low-level expression of Oct4 in cancer cells and TICs, and the participation of Oct4 in various TIC functions such as its self-renewal and survival, epithelial-mesenchymal transition (EMT) and metastasis, and drug resistance development is implicated from considerable Oct4 knockdown and overexpression-based studies.
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
New
Impact
Dang et al., Philadelphia, United States. In Cell Metab, Jan 2016
The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5'-CACGTG-3'), which are identical to the binding sites of the heterodimeric CLOCK-BMAL1 master circadian transcription factor.
Regulation of transforming growth factor-beta1 (TGF-β1)-induced pro-fibrotic activities by circadian clock gene BMAL1.
New
Sanchez et al., New Orleans, United States. In Respir Res, Dec 2015
BACKGROUND: BMAL1 is a transcriptional activator of the molecular clock feedback network.
Circadian molecular clock in lung pathophysiology.
Review
New
Rahman et al., Rochester, United States. In Am J Physiol Lung Cell Mol Physiol, Dec 2015
At the molecular level these circadian rhythms depend on the activity of an autoregulatory feedback loop oscillator of clock gene transcription factors, including the BMAL1:CLOCK activator complex and the repressors PERIOD and CRYPTOCHROME.
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.
New
Impact
Bass et al., Chicago, United States. In Science, Dec 2015
The mammalian transcription factors CLOCK and BMAL1 are essential components of the molecular clock that coordinate behavior and metabolism with the solar cycle.
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.
New
Impact
Asher et al., Israel. In Cell Metab, Dec 2015
Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1:CLOCK to conserved DNA elements.
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells.
New
Impact
Weinberg et al., Cambridge, United States. In Nature, Oct 2015
Supporting this notion, we and others previously established that the Slug epithelial-to-mesenchymal transition-inducing transcription factor (EMT-TF), a member of the Snail family, serves as a master regulator of the gland-reconstituting activity of normal mammary stem cells, and that forced expression of Slug in collaboration with Sox9 in breast cancer cells can efficiently induce entrance into the TIC state.
Molecular components of the circadian clock in mammals.
Review
New
Takahashi, Dallas, United States. In Diabetes Obes Metab, Sep 2015
The circadian clock mechanism in animals involves a transcriptional feedback loop in which the bHLH-PAS proteins CLOCK and BMAL1 form a transcriptional activator complex to activate the transcription of the Period and Cryptochrome genes, which in turn feed back to repress their own transcription.
TACTIC: Trans-Agency Consortium for Trauma-Induced Coagulopathy.
Review
New
Freeman et al., Colchester, United States. In J Thromb Haemost, Jun 2015
Trauma-induced coagulopathy (TIC) includes heterogeneous coagulopathic syndromes with different underlying causes, and treatment is challenged by limited diagnostic tests to discriminate between these entities in the acute setting.
[New impulses for tic research through international collaboration].
Review
Hoekstra et al., In Tijdschr Psychiatr, 2014
BACKGROUND: A section of the UMCG Child and Adolescent Psychiatry Department is currently focusing much of its research on tic disorders.
Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population.
Zhang et al., China. In Genet Mol Res, 2014
In the present study, we examined whether the ARNTL (BMAL1) rs2278749 T/C polymorphism was associated with the susceptibility to Alzheimer disease (AD).
Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.
GeneRIF
Gimeno et al., Boston, United States. In Endocrinology, 2012
In Ccdc80(-/-) mice, expression of the core clock member Arntl/Bmal1 was reduced whereas that of the oscillating transcription factors Dbp and Tef was increased in all tissues examined.
Development of dilated cardiomyopathy in Bmal1-deficient mice.
GeneRIF
Esser et al., Lexington, United States. In Am J Physiol Heart Circ Physiol, 2012
Loss of Bmal1, gives rise to the development of an age-associated dilated cardiomyopathy, which is associated with shifts in titin isoform composition, altered myosin heavy chain gene expression, and disruption of sarcomere structure.
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis.
GeneRIF
Andersen et al., Irvine, United States. In Proc Natl Acad Sci U S A, 2012
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis.
Period coding of Bmal1 oscillators in the suprachiasmatic nucleus.
GeneRIF
Takumi et al., Suita, Japan. In J Neurosci, 2012
This study demonistrated that Bmal1 oscillators in the suprachiasmatic nucleus.
Generation of myometrium-specific Bmal1 knockout mice for parturition analysis.
GeneRIF
Muglia et al., Saint Louis, United States. In Reprod Fertil Dev, 2011
A role for myometrial Bmal1 in maintaining normal time of day of parturition.
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