The emerging roles of Oct4 in tumor-initiating cells.
Hangzhou, China. In Am J Physiol Cell Physiol, Jan 2016
There is circumstantial evidence for low-level expression of Oct4 in cancer cells and TICs, and the participation of Oct4 in various TIC functions such as its self-renewal and survival, epithelial-mesenchymal transition (EMT) and metastasis, and drug resistance development is implicated from considerable Oct4 knockdown and overexpression-based studies.
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
Philadelphia, United States. In Cell Metab, Jan 2016
The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5'-CACGTG-3'), which are identical to the binding sites of the heterodimeric CLOCK-BMAL1 master circadian transcription factor.
Circadian molecular clock in lung pathophysiology.
Rochester, United States. In Am J Physiol Lung Cell Mol Physiol, Dec 2015
At the molecular level these circadian rhythms depend on the activity of an autoregulatory feedback loop oscillator of clock gene transcription factors, including the BMAL1:CLOCK activator complex and the repressors PERIOD and CRYPTOCHROME.
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells.
Cambridge, United States. In Nature, Oct 2015
Supporting this notion, we and others previously established that the Slug epithelial-to-mesenchymal transition-inducing transcription factor (EMT-TF), a member of the Snail family, serves as a master regulator of the gland-reconstituting activity of normal mammary stem cells, and that forced expression of Slug in collaboration with Sox9 in breast cancer cells can efficiently induce entrance into the TIC state.
Molecular components of the circadian clock in mammals.
Dallas, United States. In Diabetes Obes Metab, Sep 2015
The circadian clock mechanism in animals involves a transcriptional feedback loop in which the bHLH-PAS proteins CLOCK and BMAL1 form a transcriptional activator complex to activate the transcription of the Period and Cryptochrome genes, which in turn feed back to repress their own transcription.
TACTIC: Trans-Agency Consortium for Trauma-Induced Coagulopathy.
Colchester, United States. In J Thromb Haemost, Jun 2015
Trauma-induced coagulopathy (TIC) includes heterogeneous coagulopathic syndromes with different underlying causes, and treatment is challenged by limited diagnostic tests to discriminate between these entities in the acute setting.
Development of dilated cardiomyopathy in Bmal1-deficient mice.
Lexington, United States. In Am J Physiol Heart Circ Physiol, 2012
Loss of Bmal1, gives rise to the development of an age-associated dilated cardiomyopathy, which is associated with shifts in titin isoform composition, altered myosin heavy chain gene expression, and disruption of sarcomere structure.