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TIA1 cytotoxic granule-associated RNA binding protein-like 1

TIAR, TIAL1, TCBP
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using TIAR antibodies
Induction of neurites by the regulatory domain of PKCδ and ε in neural cells is counteracted by PKC catalytic activity and the RhoA pathway.
Supplier
Kahle Philipp J., In PLoS ONE, 2003
... GST, IGF2BP3, PABPC1, TIA1/TIAR (H-120), TIAR(C-18), HRI (S-16), and PKCα (antigen in C-terminus) antibodies were obtained from Santa Cruz, PKCα rabbit monoclonal antibody (antigen in N-terminus) from Epitomics, TIA1 and PKR from ...
Papers on TIAR
TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.
GeneRIF
Singh et al., Ames, United States. In Mol Cell Biol, 2011
TIA1 and TIAR proteins are intron-associated positive regulators of SMN2 exon 7 splicing.
TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1α pathway.
GeneRIF
Hänze et al., Gießen, Germany. In J Mol Cell Biol, 2010
Severe hypoxia caused co-aggregation of TIAR/TIA-1 and these proteins suppressed HIF-1alpha expression.
Identification of chosen apoptotic (TIAR and TIA-1) markers expression in thyroid tissues from adolescents with immune and non-immune thyroid diseases.
GeneRIF
Bossowska et al., Białystok, Poland. In Folia Histochem Cytobiol, 2010
Data show that apoptotic (TIAR and TIA-1) marker expression in thyroid tissues from adolescents with immune thyroid diseases is higher than in non-immune thyroid diseases.
Impaired embryonic development in mice overexpressing the RNA-binding protein TIAR.
GeneRIF
Morello et al., Brussels, Belgium. In Plos One, 2009
study reports the importance of the tightly balanced expression of the RNA-binding protein TIAR for normal embryonic development, thereby emphasizing the role of post-transcriptional regulations in early embryonic programming
iCLIP predicts the dual splicing effects of TIA-RNA interactions.
GeneRIF
Ule et al., Cambridge, United Kingdom. In Plos Biol, 2009
Data show that TIA1 and TIAL1 bind at the same positions on human RNAs, and are consistent with a model where TIA proteins shorten the time available for definition of an alternative exon by enhancing recognition of the preceding 5' splice site.
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