The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008] (from
... GST, IGF2BP3, PABPC1, TIA1/TIAR (H-120), TIAR(C-18), HRI (S-16), and PKCα (antigen in C-terminus) antibodies were obtained from Santa Cruz, PKCα rabbit monoclonal antibody (antigen in N-terminus) from Epitomics, TIA1 and PKR from ...
Morello et al., Brussels, Belgium. In Plos One, 2009
study reports the importance of the tightly balanced expression of the RNA-binding protein TIAR for normal embryonic development, thereby emphasizing the role of post-transcriptional regulations in early embryonic programming
Ule et al., Cambridge, United Kingdom. In Plos Biol, 2009
Data show that TIA1 and TIAL1 bind at the same positions on human RNAs, and are consistent with a model where TIA proteins shorten the time available for definition of an alternative exon by enhancing recognition of the preceding 5' splice site.