Ridley Anne J. et al., In The Journal of Cell Biology, 2007
... from Sigma-Aldrich; VE-cadherin, p120-catenin, and phospho–p120-catenin were obtained from BD; RhoA, -B, and -C and Tiam-1 were purchased from Santa Cruz Biotechnology, Inc.; Akt, pAktS473, pAktT308, ...
Wan et al., Xianning, China. In Zhongguo Dang Dai Er Ke Za Zhi, Nov 2015
OBJECTIVE: To investigate the association of single nucleotide polymorphisms (SNP) rs22833188 and rs2833195 in TIAM1 gene with the susceptibility to Kawasaki disease (KD) and its clinical characteristic in children.
Behrends et al., Frankfurt am Main, Germany. In Mol Cell, Apr 2015
Here, we identify a novel CUL3 RING ubiquitin ligase complex, containing the substrate adaptors KBTBD6 and KBTBD7, that mediates ubiquitylation and proteasomal degradation of TIAM1, a RAC1-specific GEF.
Pruitt et al., Shreveport, United States. In Oncogene, Feb 2015
Here, we demonstrate that SIRT1 and SIRT2 positively regulate the levels of Rac1-GTP and the activity of T-cell lymphoma invasion and metastasis 1 (TIAM1), a Rac guanine nucleotide exchange factor (GEF).
Mishra et al., Detroit, United States. In Diabetologia, 2014
In this study we assessed the role of T cell lymphoma invasion and metastasis (TIAM1), a guanine nucleotide exchange factor for RAC1, in RAC1 and NOX2 activation and the onset of mitochondrial dysfunction in in vitro and in vivo models of glucotoxicity and diabetes.
Sessa et al., New Haven, United States. In J Cell Sci, 2014
The loss of NO increased the recruitment of the Rac guanine-nucleotide-exchange factor (GEF) TIAM1 to adherens junctions and VE-cadherin (also known as cadherin 5), and reduced Rho activation and stress fiber formation.
Tiam1 may be involved in the aggressive behavior of ovarian cancer, and differential expression of microRNA may contribute to the dysregulation of Tiam1, which contributes to the invasive, migratory and viability properties of ovarian cancer cells
Fox et al., Cleveland, United States. In J Cell Physiol, 2011
These findings suggest a previously unrecognized mechanism of integrin-induced Rac1 activation in which 14-3-3 dimers localize Tiam1 to integrin complexes, where it mediates integrin-dependent Rac1 activation, thus initiating motility-inducing pathways.