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Thyrotropin-releasing hormone

Thyrotropin-Releasing Hormone, TRH
This hormone is responsible for the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: CAN, Prolactin, HAD, V1a, ACID
Papers on Thyrotropin-Releasing Hormone
Increased thyroid hormone activation accompanies the formation of thyroid hormone dependent negative feedback in developing chicken hypothalamus.
New
Gereben et al., Budapest, Hungary. In Endocrinology, Feb 2016
UNASSIGNED: The hypothalamic-pituitary-thyroid (HPT) axis is governed by hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons located in the hypothalamic paraventricular nucleus (PVN) under control of the negative feedback of thyroid hormones.
A Novel Thyrotropin-Releasing Hormone Receptor Missense Mutation (P81R) in Central Congenital Hypothyroidism.
New
Schoenmakers et al., Cambridge, United Kingdom. In J Clin Endocrinol Metab, Feb 2016
Recognised causes include TSH beta subunit (TSHB) and Immunoglobulin superfamily member 1 (IGSF1) mutations with only two previous reports of biallelic, highly disruptive mutations in the thyrotropin releasing hormone receptor (TRHR) gene.
Central Hypothyroidism in Miniature Schnauzers.
New
Kooistra et al., Utrecht, Netherlands. In J Vet Intern Med, Jan 2016
ANIMALS: Miniature Schnauzers with proven central hypothyroidism, based on scintigraphy, and the results of a 3-day-TSH-stimulation test, or a TSH-releasing hormone (TRH)-stimulation test or both, presented to the Department of Clinical Sciences of Companion Animals at Utrecht University or the Department of Medicine and Clinical Biology of Small Animals at Ghent University from 2008 to 2012.
Established Stem Cell Model of Spinal Muscular Atrophy Is Applicable in the Evaluation of the Efficacy of Thyrotropin-Releasing Hormone Analog.
New
Kaneko et al., Gifu, Japan. In Stem Cells Transl Med, Jan 2016
Using this model, we confirmed that treatment with the thyrotropin-releasing hormone (TRH) analog, 5-oxo-l-prolyl-l-histidyl-l-prolinamide, which had marginal effects in clinical trials, increases the SMN protein level.
Role of thyrotropin-releasing hormone in prolactin-producing cell models.
Review
New
Kyo et al., Izumo, Japan. In Neuropeptides, Dec 2015
Thyrotropin-releasing hormone (TRH) is a hypothalamic hypophysiotropic neuropeptide that was named for its ability to stimulate the release of thyroid-stimulating hormone in mammals.
60 YEARS OF NEUROENDOCRINOLOGY: TRH, the first hypophysiotropic releasing hormone isolated: control of the pituitary-thyroid axis.
Review
New
Charli et al., Ecatepec, Mexico. In J Endocrinol, Aug 2015
This review presents the findings that led to the discovery of TRH and the understanding of the central mechanisms which control hypothalamus-pituitary-thyroid axis (HPT) activity.
Gastric mucosal protection: from the periphery to the central nervous system.
Review
New
Zadori et al., Budapest, Hungary. In J Physiol Pharmacol, Jun 2015
In DVC several receptors have been identified, among others, μ and δ-opioid-, α2-adrenergic-, cannabinoid CB1- and CB2-, angiotensin II AT1-, nociceptin NOP-, neurokinin NK1- and TRH-receptors.
The molecular basis of the non-thyroidal illness syndrome.
Review
New
Boelen et al., Amsterdam, Netherlands. In J Endocrinol, Jun 2015
Downregulation of hypophysiotropic TRH neurons in the paraventricular nucleus of the hypothalamus and of TSH production in the pituitary gland points to disturbed negative feedback regulation during illness.
MECHANISMS IN ENDOCRINOLOGY: Impact of isolated TSH levels in and out of normal range on different tissues.
Review
New
Wahl et al., Tübingen, Germany. In Eur J Endocrinol, Feb 2015
Reduction of circadian changes in TSH levels, decrease of thyroid hormone-binding proteins, prevention of potential compensatory increases of TSH levels (e.g., in old age), and unresponsiveness of TSH-producing cells to TRH on l-T4 treatment might cause adverse effects of suppressed TSH levels.
Role of abnormal anterior pituitary hormones-growth hormone and prolactin in active systemic lupus erythematosus.
Li et al., Shanghai, China. In Int J Clin Exp Med, 2014
MATERIALS AND METHODS: Forty-seven subjects and ten healthy controls were assessed for possible association between SLE disease activity and levels of serum PRL, GH and thyrotropin-releasing hormone (TRH).
Thyroid hormone regulation of metabolism.
Review
Impact
Brent et al., In Physiol Rev, 2014
The thyroid gland is regulated by thyrotropin releasing hormone (TRH) and thyroid stimulating hormone (TSH).
Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions.
Review
Impact
Lechan et al., Budapest, Hungary. In Endocr Rev, 2014
TRH is a tripeptide amide that functions as a neurotransmitter but also serves as a neurohormone that has a critical role in the central regulation of the hypothalamic-pituitary-thyroid axis.
An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.
Impact
Lowell et al., Boston, United States. In Nature, 2014
Here, through the use of Cre-recombinase-enabled, cell-specific neuron mapping techniques in mice, we have discovered strong excitatory drive that, unexpectedly, emanates from the hypothalamic paraventricular nucleus, specifically from subsets of neurons expressing thyrotropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also known as ADCYAP1).
Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement.
Impact
Bernard et al., Leiden, Netherlands. In Nat Genet, 2012
Igsf1-deficient male mice show diminished pituitary and serum thyroid-stimulating hormone (TSH) concentrations, reduced pituitary thyrotropin-releasing hormone (TRH) receptor expression, decreased triiodothyronine concentrations and increased body mass.
Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.
GeneRIF
de Gortari et al., Mexico. In Endocrinology, 2012
Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.
17β-Estradiol modulates the prolactin secretion induced by TRH through membrane estrogen receptors via PI3K/Akt in female rat anterior pituitary cell culture.
GeneRIF
Torres et al., Córdoba, Argentina. In Am J Physiol Endocrinol Metab, 2012
E(2) may act as a modulator of the secretory response of lactotrophs induced by TRH through membrane estrogen receptors, with the contribution by PI3K/Akt pathway activation.
Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions.
GeneRIF
van den Pol et al., New Haven, United States. In J Neurosci, 2012
TRH inhibits melanin-concentrating hormone (MCH) neurons by increasing synaptic inhibition from local GABA neurons.
NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways.
Impact
Hollenberg et al., Boston, United States. In Cell Metab, 2012
Previous studies demonstrate that leptin communicates nutritional status to the HPT axis through thyrotropin-releasing hormone (TRH) in the paraventricular nucleus (PVN) of the hypothalamus.
Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis.
GeneRIF
Andrew et al., Baltimore, United States. In Dev Biol, 2012
expression of every tracheal gene we tested was dependent on Trh, suggesting a major role for Trh in activation and maintenance of tracheal gene expression
Thyrotropin-releasing hormone selectively stimulates human hair follicle pigmentation.
GeneRIF
Paus et al., Lübeck, Germany. In J Invest Dermatol, 2011
This study introduces TRH as a novel, potent, selective, and evolutionarily highly conserved neuroendocrine factor controlling human pigmentation in situ.
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