Central Hypothyroidism in Miniature Schnauzers.
Utrecht, Netherlands. In J Vet Intern Med, Jan 2016
ANIMALS: Miniature Schnauzers with proven central hypothyroidism, based on scintigraphy, and the results of a 3-day-TSH-stimulation test, or a TSH-releasing hormone (TRH)-stimulation test or both, presented to the Department of Clinical Sciences of Companion Animals at Utrecht University or the Department of Medicine and Clinical Biology of Small Animals at Ghent University from 2008 to 2012.
The molecular basis of the non-thyroidal illness syndrome.
Amsterdam, Netherlands. In J Endocrinol, Jun 2015
Downregulation of hypophysiotropic TRH neurons in the paraventricular nucleus of the hypothalamus and of TSH production in the pituitary gland points to disturbed negative feedback regulation during illness.
An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.
Boston, United States. In Nature, 2014
Here, through the use of Cre-recombinase-enabled, cell-specific neuron mapping techniques in mice, we have discovered strong excitatory drive that, unexpectedly, emanates from the hypothalamic paraventricular nucleus, specifically from subsets of neurons expressing thyrotropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also known as ADCYAP1).