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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, thrombopoietin, fibrillin-1
Papers using thyroglobulin antibodies
Features of benign granular cell tumor on fine needle aspiration
Jhala Darshana N et al., In CytoJournal, 1998
... avidin-biotin-peroxidase complex was used to detect the following antibodies: S-100 (Ventana; predilute), CD68 (Ventana; predilute), thyroglobulin (Cell marque; predilute), and TTF-1 (Dako; ...
Papers on thyroglobulin
Preablative stimulated thyroglobulin correlates to new therapy response system in differentiated thyroid cancer.
Lin et al., Beijing, China. In J Clin Endocrinol Metab, Feb 2016
CONTEXT: Studies suggested a potential value of preablative stimulated Tg (ps-Tg) on predicting the recurrent and persistent diseases of differentiated thyroid cancer (DTC), whereas its correlations with therapeutic response remain uncertain.
The urine iodine to creatinine as an optimal index of iodine during pregnancy in an iodine adequate area in China.
Teng et al., Shenyang, China. In J Clin Endocrinol Metab, Feb 2016
Urine iodine and creatinine and serum thyroglobulin were measured in all of the subjects.
Association between polycyclic aromatic hydrocarbons and thyroid function among males and females: data from NHANES 2007-2008.
Jain, United States. In Int J Environ Health Res, Feb 2016
Thyroid variables considered for evaluation were thyroid-stimulating hormone, free and total serum thyroxine (FT4, TT4), free and total triiodothyronine (FT3, TT3), and thyroglobulin.
Serum thyrotropin level of 30 μIU/mL is inadequate for preablative thyroglobulin to serve as a prognostic marker for differentiated thyroid cancer.
Lin et al., Beijing, China. In Endocrine, Feb 2016
PURPOSE: Preablative-stimulated thyroglobulin (ps-Tg) has manifested its potential for predicting prognosis in patients with differentiated thyroid carcinoma (DTC), but its level can be affected by thyrotropin (TSH).
Current Guidelines for Postoperative Treatment and Follow-Up of Well-Differentiated Thyroid Cancer.
Stang et al., Pittsburgh, United States. In Surg Oncol Clin N Am, Jan 2016
Long-term treatment includes thyroid-stimulating hormone suppression and surveillance with serum thyroglobulin and radiologic assessment for nodal recurrence.
Surgical Management of Lymph Node Compartments in Papillary Thyroid Cancer.
Elaraj et al., Chicago, United States. In Surg Oncol Clin N Am, Jan 2016
Sonographically suspicious lymph nodes in the lateral neck should be biopsied for cytology or thyroglobulin levels.
Attempted infanticide and suicide inaugurating catatonia associated with Hashimoto's encephalopathy: a case report.
Vidailhet et al., Strasbourg, France. In Bmc Psychiatry, Dec 2015
Complementary investigations showed elevated titres of anti-thyroglobulin and anti-thyroperoxidase antibodies (200 and 10 times, respectively, as compared to normal levels) and electroencephalography were suggestive of encephalopathy.
[CME: Radioactive iodine therapy in thyroid cancer].
Aberle et al., Zürich, Switzerland. In Praxis (bern 1994), Dec 2015
Furthermore, thyroglobulin can be used as a sensitive tumor marker.
Robotic Thyroidectomy Versus Nonrobotic Approaches: A Meta-Analysis Examining Surgical Outcomes.
Stack et al., New Orleans, United States. In Surg Innov, Dec 2015
Outcomes measured included total operative time, length of hospital stay, postoperative thyroglobulin levels, and postoperative complications.
Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves' ophthalmopathy: a review.
Wall et al., Sydney, Australia. In Clin Ophthalmol, 2014
While most authors believe that autoimmunity against the TSH receptor expressed in the orbital connective tissue cells is the main reaction that leads to the development of ophthalmopathy in patients with Graves' hyperthyroidism, an older hypothesis that deserves fresh consideration is based on the notion that thyroglobulin (Tg) in the thyroid gland passes in a retrograde fashion to the orbit where it is recognized by Tg autoantibodies, leading to inflammation.
Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial.
DECISION investigators et al., Philadelphia, United States. In Lancet, 2014
Archival tumour tissue was examined for BRAF and RAS mutations, and serum thyroglobulin was measured at baseline and at each visit.
Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity.
Rapoport et al., Los Angeles, United States. In Endocr Rev, 2014
The TSH receptor (TSHR), thyroid peroxidase (TPO), and thyroglobulin (Tg) have unusual properties ("immunogenicity") that contribute to breaking tolerance, including size, abundance, membrane association, glycosylation, and polymorphisms.
Antithyroid drugs and their analogues: synthesis, structure, and mechanism of action.
Mugesh et al., Bengaluru, India. In Acc Chem Res, 2013
The prohormone thyroxine (T4) is synthesized on thyroglobulin by thyroid peroxidase (TPO), a heme enzyme that uses iodide and hydrogen peroxide to perform iodination and phenolic coupling reactions.
Recent insights into the cell biology of thyroid angiofollicular units.
Gérard et al., Brussels, Belgium. In Endocr Rev, 2013
From onset, goiters are morphologically and functionally heterogeneous due to the polyclonal nature of the cells, with nodules distributed around areas of quiescent AFUs containing globules of compact thyroglobulin (Tg) and surrounded by a hypotrophic microvasculature.
Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer.
Fagin et al., New York City, United States. In N Engl J Med, 2013
Of the 8 patients treated with radioiodine, 5 had confirmed partial responses and 3 had stable disease; all patients had decreases in serum thyroglobulin levels (mean reduction, 89%).
Human fibrocytes coexpress thyroglobulin and thyrotropin receptor.
Smith et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2012
Findings suggest that thyroglobulin (Tg) and thyroid-stimulating hormone receptor (TSHR) detected in orbital connective tissues in thyroid-associated ophthalmopathy (TAO) result from local fibrocyte biosynthetic activity.
Evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto's thyroiditis.
Schott et al., Düsseldorf, Germany. In J Clin Endocrinol Metab, 2012
Data suggest that in Hashimoto's thyroiditis, both antigens, TG and thyroperoxidase, are recognized by peripheral and thyroid gland infiltrating CD8-positive T-cells and are involved in thyroid destruction leading to clinical disease manifestation.
Epistasis between the HSD17B4 and TG polymorphisms is associated with premature ovarian failure.
Kwack et al., South Korea. In Fertil Steril, 2012
Epistasis between the HSD17B4 and thyroglobulin polymorphisms is associated with premature ovarian failure.
Thyroid hyperactivity with high thyroglobulin in serum despite sufficient iodine intake in chronic cold adaptation in an Arctic Inuit hunter population.
Laurberg et al., Aalborg, Denmark. In Eur J Endocrinol, 2012
Cold exposure influences thyroid hormones and TG activity in serum in Arctic populations consistent with consumption of thyroid hormone and higher thyroid hormone turnover.
Clinical and genetic analysis of a compound heterozygous mutation in the thyroglobulin gene in a Chinese twin family with congenital goiter and hypothyroidism.
Ma et al., Qingdao, China. In Twin Res Hum Genet, 2012
compound heterozygous mutation in the TG gene in a Chinese twin family with congenital goiter and hypothyroidism; study provides further evidence that TG mutations cause congenital goiter and hypothyroidism, demonstrates genetic heterogeneity of the mutation and increases understanding of phenotype-genotype correlations
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