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Thymosin beta 4, X-linked

thymosin beta 4, Tbeta4
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using thymosin beta 4 antibodies
Thymosin beta 4 is involved in stabilin-2-mediated apoptotic cell engulfment.
Sham Mai Har, In PLoS ONE, 2007
... Tissue sections were incubated (30 min at room temperature) with the monoclonal anti-thymosin beta 4 antibody (Bachem, Bubendorf, Switzerland) ...
Different hepatocytes express the cholesterol 7 alphe hydroxylase gene during its circadian modulation in vivo
Faa G. et al., In European Journal of Histochemistry : EJH, 1994
... for 60 min to block non-specific binding, followed by incubation (20 h, 4°C) with polyclonal anti-thymosin beta 4 antibody (Bachem-Peninsula Lab, San Carlos, CA, ...
Papers on thymosin beta 4
Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.
Moon et al., Seoul, South Korea. In Int J Cancer, 2012
investigated whether GSK-3 activity is regulated by thymosin beta-4 (Tbeta4) and associated with Tbeta4-mediated migration in gastric cancer cells; expression of GSK-3alpha, beta-catenin and E-cadherin could be negatively regulated by Tbeta4 induced ERK phosphorylation; suggests that Tbeta4 could be a novel regulator to control Wnt signal pathway
Thymosin β4 promotes the migration of endothelial cells without intracellular Ca2+ elevation.
Cierniewski et al., Łódź, Poland. In Exp Cell Res, 2012
The Our data confirm the concept that externally added Tbeta4 must be internalized to induce intracellular mechanisms supporting endothelial cell migration.
Interleukin-18-mediated interferon-gamma secretion is regulated by thymosin beta 4 in human NK cells.
Cho et al., Seoul, South Korea. In Immunobiology, 2011
Tbeta4 is regulated by IL-18 and is involved in IL-18-enhanced IFN-gamma secretion in NK cells.
Increased levels of thymosin β4 in synovial fluid of patients with rheumatoid arthritis: association of thymosin β4 with other factors that are involved in inflammation and bone erosion in joints.
Kim et al., Seoul, South Korea. In Int J Rheum Dis, 2011
Thymosin beta4 Tbeta4 may play an important role in bone degradation and inflammation in RA but not OA.
Thymosin-β4 (Tβ4) blunts PDGF-dependent phosphorylation and binding of AKT to actin in hepatic stellate cells.
Rojkind et al., Washington, D.C., United States. In Am J Pathol, 2011
findings suggest that Tbeta4 by sequestering actin prevents binding of AKT, thus inhibiting its phosphorylation
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