thymosin beta 4
thymosin beta 4
Thymosin β4 and cardiac regeneration: are we missing a beat?
New York City, United States. In Stem Cell Rev, 2013
Priming with thymosin beta 4, a peptide which has been suggested to be critical for cardiac development and to have cardio-protective properties, was recently shown to induce differentiation of EPDCs into cardiomyocytes in a small animal model of myocardial infarction.
Thymosin β4: a potential novel dry eye therapy.
Detroit, United States. In Ann N Y Acad Sci, 2012
The purpose of this manuscript is to review the clinical entity of dry eye syndrome (DES) and to provide a scientific basis and rationale for the usage of thymosin beta 4 (Tβ4) as a novel therapy for DES.
Thymosin β4 protein therapy for cardiac repair.
London, United Kingdom. In Curr Pharm Des, 2011
Although, future regenerative approaches may likely involve a synergistic protein cocktail, this review will focus on the role of a promising candidate, thymosin beta 4 (Tβ4) in cardioprotection, neovascularization, tissue regeneration and inflammation - all essential components in cardiac repair.
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.
London, United Kingdom. In Nature, 2007
Here we identify thymosin beta4 (Tbeta4) as essential for all aspects of coronary vessel development in mice, and demonstrate that Tbeta4 stimulates significant outgrowth from quiescent adult epicardial explants, restoring pluripotency and triggering differentiation of fibroblasts, smooth muscle cells and endothelial cells.
Actin binding proteins: regulation of cytoskeletal microfilaments.
Sydney, Australia. In Physiol Rev, 2003
In this review we selected several ABPs (ADF/cofilin, profilin, gelsolin, thymosin beta4, DNase I, CapZ, tropomodulin, and Arp2/3) that regulate actin-driven assembly, i.e., movement that is independent of motor proteins.