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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Thymopoietin

Thymopentin, thymopoietin, POT1, 3-ketoacyl-CoA thiolase
The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, TRF2, TRF1
Papers using Thymopentin antibodies
Arginine methylation regulates telomere length and stability
Supplier
Loayza Diego et al., In Aging (Albany NY), 2008
... The POT1 and POT1∆C fusion with eGFP where performed using a vector constructed with the eGFP fragment from the pEGFP-C1 vector (Clontech) subcloned into pBabe-Puro ...
Papers on Thymopentin
Melanoma genetics.
Review
New
Hayward et al., Brisbane, Australia. In J Med Genet, Jan 2016
Susceptibility for some families is due to mutation in one of the known high penetrance melanoma predisposition genes: CDKN2A, CDK4, BAP1, POT1, ACD, TERF2IP and TERT.
Recent developments in brain tumor predisposing syndromes.
New
Melin et al., Umeå, Sweden. In Acta Oncol, Jan 2016
Recent findings from the GLIOGENE collaboration and the newly identified glioma causing gene POT1, will also be discussed.
Downregulation of telomerase maintenance-related ACD expression in patients undergoing immunosuppresive therapy following kidney transplantation.
New
Gumprecht et al., Zabrze, Poland. In Exp Ther Med, Dec 2015
Among the analyzed transcripts, the expression levels of 4 differed significantly between the studied groups; however, only the ACD (adrenocortical dysplasia homolog) gene, encoding the telomere-binding protein POT1-interacting protein 1 (TPP1), was sufficiently specific for telomere homeostasis.
ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres.
New
Bryan et al., Sydney, Australia. In Cell Rep, Dec 2015
ATM and ATR depletion reduced assembly of the telomerase complex, and ATM was required for telomere elongation in cells expressing POT1ΔOB, an allele of POT1 that disrupts telomere-length homeostasis.
Telomere maintenance and the etiology of adult glioma.
Review
New
Wrensch et al., Rochester, United States. In Neuro Oncol, Nov 2015
Exome sequencing of glioma patients from families with multiple affected members has identified rare inherited mutations in POT1 (protection of telomeres protein 1) as high-penetrance glioma risk factors.
Inhibition of mitochondrial β-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo.
New
Datta et al., Delhi, India. In Int J Obes (lond), Nov 2015
Cells were treated with tunicamycin (Tm, 1 h) and 4-PBA (4-phenyl butyric acid, 8 h) or transfected with hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, apha subunit (HADHA) short interfering RNA or its overexpression vector.
Update in genetic susceptibility in melanoma.
Review
New
Puig et al., Barcelona, Spain. In Ann Transl Med, Sep 2015
The technologic advances have allowed the identification of new genes involved in melanoma susceptibility: Breast cancer 1 (BRCA1) associated protein 1 (BAP1), CXC genes, telomerase reverse transcriptase (TERT), protection of telomeres 1 (POT1), ACD and TERF2IP, the latter four being involved in telomere maintenance.
The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner.
Autexier et al., Montréal, Canada. In Mol Cell Biol, 2014
One hTERT IFD variant, hTERT-L805A, with reduced activity and processivity showed impaired telomere association, which could be partially rescued by overexpression of TPP1-POT1.
Interventions for prevention of herpes simplex labialis (cold sores on the lips).
Review
Kanjirath et al., Taiwan. In Cochrane Database Syst Rev, 2014
These RCTs did not report adverse events.There were very few data suggesting that thymopentin, low-level laser therapy, and hypnotherapy are effective in preventing recurrent HSL, with one to two RCTs for each intervention.
Shelterin proteins and cancer.
Review
Trivedi et al., Vellore, India. In Asian Pac J Cancer Prev, 2014
It comprises six proteins, namely TRF1, TRF2, TIN2, POT1, TPP1 and RAP1.
POT1 loss-of-function variants predispose to familial melanoma.
Impact
Adams et al., Sanger, United States. In Nat Genet, 2014
We identified families where melanoma cosegregates with loss-of-function variants in the protection of telomeres 1 gene (POT1), with a proportion of family members presenting with an early age of onset and multiple primary tumors.
Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma.
Impact
Landi et al., Bethesda, United States. In Nat Genet, 2014
Using whole-exome sequencing, we identified a rare variant that arose as a founder mutation in the telomere shelterin gene POT1 (chromosome 7, g.124493086C>T; p.Ser270Asn) in five unrelated melanoma-prone families from Romagna, Italy.
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
Impact
Houlston et al., United Kingdom. In Nat Genet, 2014
A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)).
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Impact
Zhuang et al., New York City, United States. In Cell, 2013
Conditional deletion of individual components of shelterin showed that TRF2 was required for the formation and/or maintenance of t-loops, whereas deletion of TRF1, Rap1, or the POT1 proteins (POT1a and POT1b) had no effect on the frequency of t-loop occurrence.
Cancer chromosomes going to POT1.
Impact
Chang, New Haven, United States. In Nat Genet, 2013
Alterations in the single-stranded telomere-binding protein POT1 have recently been identified in chronic lymphocytic leukemia.
Estrogen receptor alpha interacts with mitochondrial protein HADHB and affects beta-oxidation activity.
GeneRIF
Du et al., Fayetteville, United States. In Mol Cell Proteomics, 2012
HADHB is a functional molecular target of estrogen receptor alpha in the mitochondria, and the interaction may play an important role in the estrogen-mediated lipid metabolism in animals and humans.
DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.
GeneRIF
Cech et al., Boulder, United States. In Nucleic Acids Res, 2012
Results indicate an unanticipated ssDNA-binding mode in which two SpPot1 molecules bind an oligonucleotide containing two telomeric repeats.
A patient with mitochondrial trifunctional protein deficiency due to the mutations in the HADHB gene showed recurrent myalgia since early childhood and was diagnosed in adolescence.
GeneRIF
Matsuo et al., Kōbe, Japan. In Mol Genet Metab, 2011
mutational analysis of the HADHB gene, which encodes long-chain 3-ketoacyl-CoA thiolase, identified compound heterozygous mutations of c.520C>T (p.R141C) and c.1331G>A (p.R411K) in a case of mitochondrial trifunctional protein deficiency
Telomere protection by TPP1/POT1 requires tethering to TIN2.
GeneRIF
de Lange et al., New York City, United States. In Mol Cell, 2011
Telomere protection by TPP1/POT1 requires tethering to TIN2.
Deregulated LAP2α expression in cervical cancer associates with aberrant E2F and p53 activities.
GeneRIF
Leaner et al., Cape Town, South Africa. In Iubmb Life, 2011
this study provides evidence for elevated LAP2alpha expression in cervical cancer and suggests that E2F and p53 activities associate with the positive and negative regulation of LAP2alpha expression, respectively
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