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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Deoxythymidylate kinase

thymidylate kinase, TMPK, dTMP kinase
Top mentioned proteins: CAN, ACID, POLYMERASE, TmP, HAD
Papers on thymidylate kinase
Enzymatic Manufacture of Deoxythymidine-5'-Triphosphate with Permeable Intact Cells of E. coli Coexpressing Thymidylate Kinase and Acetate Kinase.
Ou et al., Shanghai, China. In J Microbiol Biotechnol, Jan 2016
A one-pot process of enzymatic synthesis of deoxythymidine-5'-triphosphate (5'-dTTP) employing whole cells of recombinant Escherichia coli coexpressing thymidylate kinase (TMKase) and acetate kinase (ACKase) was developed.
5-Arylaminouracil Derivatives: New Inhibitors of Mycobacterium tuberculosis.
Khandazhinskaya et al., Moscow, Russia. In Chem Biol Drug Des, Dec 2015
In addition, the thymidylate kinase of M. tuberculosis was evaluated as a possible enzymatic target.
Biochemical and Structural Characterization of Polyphosphate Kinase 2 from the Intracellular Pathogen Francisella tularensis.
Roach et al., Southampton, United Kingdom. In Biosci Rep, Dec 2015
The structure consists of a 6- stranded parallel β sheet surrounded by 12 α helices, with a high degree of similarity to other members of the PPK2 family and the thymidylate kinase superfamily.
Designing, synthesis of selective and high-affinity chalcone-benzothiazole hybrids as Brugia malayi thymidylate kinase inhibitors: In vitro validation and docking studies.
Saxena et al., Lucknow, India. In Eur J Med Chem, Nov 2015
In our continuing search for safe and efficacious antifilarials, a series of novel chalcone-benzothiazole hybrids have been synthesized and evaluated for their Brugia malayi thymidylate kinase (BmTMK) enzyme inhibition activity.
A novel viral thymidylate kinase with dual kinase activity.
Sotelo-Mundo et al., Hermosillo, Mexico. In J Bioenerg Biomembr, Oct 2015
Nucleotide phosphorylation is a key step in DNA replication and viral infections, since suitable levels of nucleotide triphosphates pool are required for this process.
Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis.
Medin et al., Sendai, Japan. In Methods Mol Biol, 2014
We have developed a robust suicide gene therapy enzyme/prodrug system based on an engineered variant of the human thymidylate kinase (TMPK), which has been endowed with the ability to drive azidothymidine (AZT) activation.
Selective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells.
Eriksson et al., Uppsala, Sweden. In Nucleosides Nucleotides Nucleic Acids, 2014
locked deoxycytidine (S-MCdC, N-MCdC), and deoxyadenosine analogs (S-MCdA and N-MCdA) were examined as substrates for purified preparations of human deoxynucleoside kinases: dCK, dGK, TK2, TK1, the ribonucleoside kinase UCK2, two NMP kinases (CMPK1, TMPK) and a NDP kinase.
New tuberculostatic agents targeting nucleic acid biosynthesis: drug design using QSAR approaches.
Andrade et al., Goiânia, Brazil. In Curr Pharm Des, 2013
This review presents the current progress and applications of structure-activity relationship analysis for the discovery of innovative tuberculostatic agents as inhibitors of ribonucleotide reductase, DNA gyrase, ATP synthase, and thymidylate kinase enzymes, highlighting present challenges and new opportunities in TB drug design.
Thymidylate kinase: an old topic brings new perspectives.
Yin et al., Jinan, China. In Curr Med Chem, 2012
Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5'-diphosphate (dTDP), which is then converted to thymidine 5'-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK).
Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair.
Chang et al., Taipei, Taiwan. In Cancer Cell, 2012
The synthesis of dTDP is unique because there is a requirement for thymidylate kinase (TMPK).
Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status.
Chang et al., Taipei, Taiwan. In Cancer Res, 2008
Lentiviral delivery of small hairpin RNA targeting TMPK in combination with a low dose of doxorubicin as a new approach to kill colon cancer cells regardless of p53 status.
Mitotic control of dTTP pool: a necessity or coincidence?
Chang et al., Taipei, Taiwan. In J Biomed Sci, 2007
Intracellular thymidine is salvaged to dTTP by cytosolic thymidine kinase (TK1) and thymidylate kinase (TMPK), both of which expression increase in the G1/S transition and diminish in the mitotic phase via proteolytic destruction.
Structure-aided design of inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Van Calenbergh, Gent, Belgium. In Verh K Acad Geneeskd Belg, 2005
Antiviral chemotherapy often relies on nucleoside analogues, which, once phophorylated by intracellular kinases, target viral polymerases and preclude DNA synthesis.
Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase.
Konrad et al., Chicago, United States. In Mini Rev Med Chem, 2004
Human thymidylate kinase (TMPK), apart from its essential physiological role in the biosynthesis of TTP, is also required for the activation of thymidine analogs, such as the clinically used anti-HIV prodrugs AZT and d4T.
The bottleneck in AZT activation.
Goody et al., Dortmund, Germany. In Nat Med, 1997
Thus, for the most extensively used drug, 3'-azido-3'-deoxythymidine (AZT), whereas phosphorylation to the monophosphate is facile, the product is a very poor substrate for the next kinase in the cascade, thymidylate kinase.
HODAS et al., In Science, 1964
Hydroxyurea does not affect thymidine kinase, thymidylate kinase, or DNA polymerase reactions, but it does inhibit incorporation of cytidylic and guanylic acids into DNA in cell-free supernatants.
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