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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Thymidine kinase 1, soluble

thymidine kinase
Top mentioned proteins: CAN, HAD, V1a, POLYMERASE, ACID
Papers using thymidine kinase antibodies
Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
Supplier
Aguila Marcia B., In PLoS ONE, 1998
... thymidine kinase (tk) promoter from pTKβ (Clontech, Mountain View, CA, USA) ...
Papers on thymidine kinase
Exome-wide single-base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse.
New
Huebner et al., Nagasaki, Japan. In Cancer Sci, Feb 2016
The increase in T>C mutations in -/- exomes may be due to dNTP imbalance, particularly in thymidine triphosphate, resulting from decreased expression of Thymidine Kinase 1 in Fhit-deficient cells.
An improved single-step cloning strategy simplifies the Agrobacterium tumefaciens-mediated transformation (ATMT)-based gene disruption method in Verticillium dahliae.
New
Zhang et al., Beijing, China. In Phytopathology, Feb 2016
Here, we generated a USER-ATMT-dual selection (DS) binary vector, which combines both the advantages of the USER single-step cloning technique and the efficiency of the herpes simplex virus thymidine kinase (HSVtk) negative selection marker.
Potential Prophylactic Properties of Apple and Characterization of Potent Bioactive from cv. "Granny Smith" Displaying Strong Antimutagenicity in Models Including Human Lymphoblast TK6(+/-) Cell Line.
New
Gautam et al., Mumbai, India. In J Food Sci, Feb 2016
The above observed antimutagenicity in bacterial assay system was well reproduced in Thymidine Kinase Mutation (TKM) assay performed using human lymphoblast cell line (TK6(+/-) ) cell line making the findings more prophylactically relevant.
Prognostic Factors for Chronic Lymphocytic Leukemia.
Review
New
Puvvada et al., Tucson, United States. In Curr Hematol Malig Rep, Feb 2016
The prognostic information can be categorized into three categories: genetic abnormalities which include 17p, 11q, and immunoglobulin heavy chain variable (IGHV) abnormalities; biochemical abnormalities and cell surface markers which include serum thymidine kinase, β-2-microglobulin, CD49d, CD38, and ZAP-70 levels; and patient characteristics which include sex, age, and performance status.
Evaluation of serum markers in the LRF CLL4 trial: β2m but not serum free light chains, is an independent marker of overall survival.
New
Oscier et al., Bournemouth, United Kingdom. In Leuk Lymphoma, Feb 2016
The current study evaluated the prognostic significance of serum free light chains (sFLC, kappa and lambda) and other serum markers (β2M, serum thymidine kinase (sTK), soluble CD23 and LDH) together with established biomarkers in 289 patients enrolled into the LRF CLL4 trial.
Prognostic Significance of Serum Tumor Markers in Patients with Advanced-stage NSCLC Treated with Pemetrexed-based Chemotherapy.
New
Topolcan et al., Praha, Czech Republic. In Anticancer Res, Jan 2016
We focused on evaluating the predictive and prognostic role of the seven following tumor biomarkers: carcinoembryonic antigen (CEA), cytokeratin-19 fragment (CYFRA 21-1), fragments of cytokeratin 8, 18 and 19 (MonoTotal), neuron-specific enolase (NSE), chromogranin A, thymidine kinase (TK) and squamous cell carcinoma antigen (SCCA) in patients with advanced-stage NSCLC treated with pemetrexed-based chemotherapy.
Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.
Review
New
Zell et al., Jena, Germany. In J Antimicrob Chemother, Jan 2016
However, an essential precondition is a broad knowledge of natural polymorphisms and resistance-associated mutations in the thymidine kinase (TK) and DNA polymerase (pol) genes, of which the DNA polymerase (Pol) enzyme is targeted by the highly effective antiviral drugs in clinical use.
(18)F-FLT PET imaging of cellular proliferation in pancreatic cancer.
Review
New
Valle et al., Manchester, United Kingdom. In Crit Rev Oncol Hematol, Jan 2016
Particularly, tumour proliferation may be assessed by measurement of intracellular thymidine kinase 1 (TK1) activity level using thymidine analogues radiolabelled with a positron emitter for use with PET.
Therapeutic potential of TAS-102 in the treatment of gastrointestinal malignancies.
Review
New
Peters, Amsterdam, Netherlands. In Ther Adv Med Oncol, Nov 2015
TAS-102 also follows an alternative activation pathway via thymidine kinase, and is not a substrate for dihydropyrimidine dehydrogenase.
Improving the safety of cell therapy with the TK-suicide gene.
Review
Ciceri et al., Milano, Italy. In Front Pharmacol, 2014
The herpes simplex virus thymidine kinase (HSV-TK) is the suicide gene most extensively tested in humans.
Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial.
Impact
ASPECT Study Group et al., Hamburg, Germany. In Lancet Oncol, 2013
We assessed the efficacy and safety of a locally applied adenovirus-mediated gene therapy with a prodrug converting enzyme (herpes-simplex-virus thymidine kinase; sitimagene ceradenovec) followed by intravenous ganciclovir in patients with newly diagnosed resectable glioblastoma.
High baseline serum thymidine kinase 1 level predicts unfavorable outcome in patients with follicular lymphoma.
GeneRIF
Papajík et al., Olomouc, Czech Republic. In Leuk Lymphoma, 2012
Data suggest that serum thymidine kinase 1 (TK1) levels may help to refine risk assessment in the modern immunotherapy era.
Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1.
GeneRIF
Munch-Petersen et al., Roskilde, Denmark. In Febs J, 2012
The crystal structure of the T163S-mutated HuTK1 reveals a less ordered conformation of the ligand thymidine triphosphate compared with the wild-type structure
High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma.
GeneRIF
Skog et al., Nanjing, China. In Tumour Biol, 2012
TK1 may be involved in poor survival in patients with pT1 of lung adenocarcinoma
Polymorphic mutations associated with the emergence of the multinucleoside/tide resistance mutations 69 insertion and Q151M.
GeneRIF
Swiss HIV Cohort Study et al., Zürich, Switzerland. In J Acquir Immune Defic Syndr, 2012
frequencies of polymorphic mutations in HIV-1 (subtype B) were compared between patients detected with the 69 insertion (n = 17), Q151M (n = 29), >/=2 thymidine analogue mutations (TAM) 1 (n = 400) or >/=2 TAM 2 (n = 249).
Quaternary structures of recombinant, cellular, and serum forms of thymidine kinase 1 from dogs and humans.
GeneRIF
Staffan et al., Uppsala, Sweden. In Bmc Biochem, 2011
results suggest that the serum TK1 protein differs from cellular or recombinant forms, is more active in high molecular weight complexes, and is sensitive to reducing agents
Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma.
Impact
New et al., Columbus, United States. In J Clin Oncol, 2011
AdV-tk, an adenoviral vector containing the herpes simplex virus thymidine kinase gene, plus prodrug synergizes with surgery and chemoradiotherapy, kills tumor cells, has not shown MGMT dependency, and elicits an antitumor vaccine effect.
A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography.
Impact
Gambhir et al., Cambridge, United Kingdom. In Nat Med, 2010
We molecularly engineered a positron emission tomography (PET)-based split reporter (herpes simplex virus type 1 thymidine kinase), cleaved between Thr265 and Ala266, and used this in a protein-fragment complementation assay (PCA) to quantify PPIs in mammalian cells and to microPET image them in living mice.
Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group.
Impact
German Chronic Lymphocytic Leukemia Study Group et al., Ulm, Germany. In J Clin Oncol, 2009
Efficacy did not vary significantly in subgroups defined by genetic parameters (in particular, in 17p deletion, 11q deletion, mutated TP53, and unmutated VH), but efficacy was inferior in patients with increased beta2-microglobulin (beta2-MG) and thymidine kinase (TK).
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study.
Impact
Bordignon et al., Milano, Italy. In Lancet Oncol, 2009
METHODS: In a phase I-II, multicentre, non-randomised trial of haploidentical stem-cell transplantation, we infused donor lymphocytes expressing herpes-simplex thymidine kinase suicide gene (TK-cells) after transplantation.
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