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Thymic stromal lymphopoietin

thymic stromal lymphopoietin, TSLP
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: TH2, CAN, IL-4, IL-13, IL-33
Papers using thymic stromal lymphopoietin antibodies
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
Supplier
Hummler Edith et al., In Nature Communications, 2003
... TSLP quantitative RT–PCR analyses of wild-type and transgenic skin in 2-day-old pups ...
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin
Supplier
Ziegler Steven F. et al., In The Journal of Experimental Medicine, 2001
... Generation of inducible skin-specific TSLP transgenic mice (K5-rtTA/tetO-TSLP). ...
Papers on thymic stromal lymphopoietin
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.
New
Impact
Locksley et al., San Francisco, United States. In Nature, Feb 2016
Experiments in mice and humans have demonstrated requirements for the epithelial cytokines IL-33, thymic stromal lymphopoietin (TSLP) and IL-25 in the activation of ILC2s, but the sources and regulation of these signals remain poorly defined.
Aspergillus fumigatus promotes T helper type 2 responses through thymic stromal lymphopoietin production by human corneal epithelial cells.
New
Wu et al., China. In Clin Experiment Ophthalmol, Feb 2016
Here, we explored the potential role of TSLP in adaptive immunity of fungal keratitis.
Inhibitory effects of nicotine derived from cigarette smoke on thymic stromal lymphopoietin production in epidermal keratinocytes.
New
Hirasawa et al., Sendai, Japan. In Cell Immunol, Feb 2016
UNASSIGNED: Thymic stromal lymphopoietin (TSLP) is regarded as the main factor responsible for the pathogenesis of atopic dermatitis (AD).
Airway inflammation in asthma: key players beyond the Th2 pathway.
Review
New
KleinJan, Rotterdam, Netherlands. In Curr Opin Pulm Med, Jan 2016
ILC2s respond to IL-25, IL-33, thymic stromal lymphopoietin, and leukotrienes by producing IL-4, IL-5, and IL-13.
Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model.
New
Tanaka et al., Fuchū, Japan. In J Invest Dermatol, Jan 2016
Alkalinization of the skin of asymptomatic NC/Tnd mice housed in specific pathogen-free conditions induced kallikrein 5 and activated protease-activated receptor 2, resulting in thymic stromal lymphopoietin secretion and a cutaneous T-helper 2 allergic response.
Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics.
New
Kasetty et al., Lund, Sweden. In Plos One, Dec 2015
In vitro, OPN bound lactoferrin, secretory leukocyte peptidase inhibitor (SLPI), midkine, human beta defensin-3 (hBD-3), and thymic stromal lymphopoietin (TSLP) but showed low or no affinity for lysozyme and LL-37.
Cordycepin Suppresses Thymic Stromal Lymphopoietin Expression via Blocking Caspase-1 and Receptor-Interacting Protein 2 Signaling Pathways in Mast Cells.
New
Jeong et al., In Biol Pharm Bull, Dec 2015
Mast cell-derived thymic stromal lymphopoietin (TSLP) plays an important role in the pathogenesis of allergic inflammatory reactions.
Drivers of chronic rhinosinusitis: Inflammation versus infection.
Review
New
Hamilos, Boston, United States. In J Allergy Clin Immunol, Dec 2015
Conversely, certain innate factors, namely IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), are elaborated by sinus epithelial cells in response to microbial stimulation or airway injury and promote local TH2 inflammation.
An allergist's perspective to the evaluation of Eosinophilic Esophagitis.
Review
New
Spergel, Philadelphia, United States. In Best Pract Res Clin Gastroenterol, Oct 2015
In addition, it shares atopic genetic risk factors including thymic stromal lymphopoietin (TSLP) loci as a risk factor in genome wide association studies.
Allergic mechanisms of Eosinophilic oesophagitis.
Review
New
Shen et al., Boston, United States. In Best Pract Res Clin Gastroenterol, Oct 2015
Th2-cytokines like IL-4, IL-5 and IL-13, and other cytokines like TGFβ and TSLP are involved, but perhaps no one cytokine is critically important for driving the disease.
Barrier Epithelial Cells and the Control of Type 2 Immunity.
Review
New
Impact
Lambrecht et al., Gent, Belgium. In Immunity, Aug 2015
These ECs mount a prototypical response made up of chemokines, innate cytokines such as interleukin-1 (IL-1), IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), as well as the alarmins uric acid, ATP, HMGB1, and S100 proteins.
Hypothetical Atopic Dermatitis-Myeloproliferative Neoplasm Syndrome.
Review
Kawakami et al., Los Angeles, United States. In Front Immunol, 2014
Common pathways for skin inflammation encompass overexpression of thymic stromal lymphopoietin and reduced signaling of epidermal growth factor receptor in the epidermis, while overproduction of granulocyte-colony-stimulating factor by keratinocytes and constitutive activation of Stat5 in hematopoietic stem cells are important for the development of MPN.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
Effects of an anti-TSLP antibody on allergen-induced asthmatic responses.
Impact
Parnes et al., Vancouver, Canada. In N Engl J Med, 2014
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an epithelial-cell-derived cytokine that may be important in initiating allergic inflammation.
Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
Impact
Locksley et al., San Francisco, United States. In Immunity, 2014
We show that inhaled chitin induced expression of three epithelial cytokines, interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP), which nonredundantly activated resident innate lymphoid type 2 cells (ILC2s) to express IL-5 and IL-13 necessary for accumulation of eosinophils and alternatively activated macrophages (AAMs).
Thymic stromal lymphopoietin is regulated by the intracellular calcium.
GeneRIF
Jeong et al., Seoul, South Korea. In Cytokine, 2012
Calcium regulates the level of TSLP through RIP2/caspase-1/NF-kappaB/IkappaBalpha signal.
DC-derived TSLP promotes Th2 polarization in LPS-primed allergic airway inflammation.
GeneRIF
Zhou et al., Hangzhou, China. In Eur J Immunol, 2012
Tslp released by dendritic cells in response to a low concentration of LPS plays a role in priming Th2 differentiation and may serve as a polarizing signal.
Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin.
GeneRIF
Kato et al., Chicago, United States. In J Allergy Clin Immunol, 2012
Pathogens producing dsRNA, such as respiratory viral infections, might amplify local T(H)2 inflammation in asthmatic patients through the production of TSLP and IL-1 by epithelial cells and activation of T(H)2 cytokine production by mast cells.
TSLP signaling network revealed by SILAC-based phosphoproteomics.
GeneRIF
Pandey et al., Baltimore, United States. In Mol Cell Proteomics, 2012
phosphoproteomic analysis of the TSLP signaling pathway that greatly expands the understanding of TSLP signaling
The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond.
Review
GeneRIF
Ziegler et al., Seattle, United States. In J Leukoc Biol, 2012
TSLP may impact multiple disease states within multiple organ systems, including the blockade of TH1/TH17 responses and the promotion of cancer and autoimmunity
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