Versican: a novel modulator of hepatic fibrosis.
Prince George, Canada. In Lab Invest, Feb 2016
Expression of versican, A Disintegrin-like and Metalloproteinase with Thrombospondin-1 motifs (ADAMTS)-1, -4, -5, -8, -9, -15, and -20, and markers of fibrogenesis were studied using immunohistochemistry, real-time quantitative PCR, and western blotting.
The pituitary TGFβ1 system as a novel target for the treatment of resistant prolactinomas.
Buenos Aires, Argentina. In J Endocrinol, Jan 2016
TGFβ1 is secreted to the extracellular matrix as an inactive latent complex, and its bioavailability is tightly regulated by different components of the ´TGFβ1 system including latent binding proteins (LTBPs), local activators (Thrombospondin-1, matrix metalloproteases, integrins, among others), and TGFβ receptors.
Physiological capillary regression is not dependent on reducing VEGF expression.
Morgantown, United States. In Microcirculation, Jan 2016
Thrombospondin-1 (TSP-1), a negative angiogenic regulator, is increasingly being observed to temporally correlate with capillary regression, suggesting that increased TSP-1 (and not reduction in VEGF per se) is needed to initiate, and likely regulate, capillary regression.
Thyroid Hormone, Hormone Analogs, and Angiogenesis.
Albany, United States. In Compr Physiol, 2014
From αvβ3, Nanotetrac also downregulates expression of VEGFA and epidermal growth factor receptor (EGFR) genes, upregulates transcription of the angiogenesis suppressor gene, thrombospondin 1 (THBS1; TSP1) and decreases cellular abundance of Ang-2 protein and matrix metalloproteinase-9.