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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Thrombospondin 1

thrombospondin-1, TSP-1, Thrombospondin
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, CAN, V1a, HAD, CD47
Papers on thrombospondin-1
IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway.
New
Long et al., Wuhan, China. In J Oral Pathol Med, Feb 2016
METHODS: Expressions of vascular endothelial growth factor (VEGF), angiogenin-1 (Ang-1), chondromodulin-1 (ChM-1), and thrombospondins-1 (TSP-1) were compared between healthy and perforated TMJ disk cells with or without interleukin-1β (IL-1β) incubation.
Versican: a novel modulator of hepatic fibrosis.
New
Winwood et al., Prince George, Canada. In Lab Invest, Feb 2016
Expression of versican, A Disintegrin-like and Metalloproteinase with Thrombospondin-1 motifs (ADAMTS)-1, -4, -5, -8, -9, -15, and -20, and markers of fibrogenesis were studied using immunohistochemistry, real-time quantitative PCR, and western blotting.
Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.
New
Zhuang et al., Shiqi, China. In Oncotarget, Feb 2016
Previous studies have demonstrated that Thrombospondin-1 (TSP-1) is associated with neurogenesis, neovascularization and tumorigenesis.
Association of thrombogenic gene polymorphisms with hepatocellular carcinoma in HCV Egyptian patients.
New
Mohamed et al., Az Zaqāzīq, Egypt. In Gene, Feb 2016
We aimed to investigate the association between mutations in Factor V, prothrombin gene and thrombospondin 1 polymorphisms with hepatic fibrosis progression rate and development of HCC in patients infected with HCV and if they are potential markers for early prediction of disease progression.
The pituitary TGFβ1 system as a novel target for the treatment of resistant prolactinomas.
Review
New
Diaz-Torga et al., Buenos Aires, Argentina. In J Endocrinol, Jan 2016
TGFβ1 is secreted to the extracellular matrix as an inactive latent complex, and its bioavailability is tightly regulated by different components of the ´TGFβ1 system including latent binding proteins (LTBPs), local activators (Thrombospondin-1, matrix metalloproteases, integrins, among others), and TGFβ receptors.
Physiological capillary regression is not dependent on reducing VEGF expression.
Review
New
Olfert, Morgantown, United States. In Microcirculation, Jan 2016
Thrombospondin-1 (TSP-1), a negative angiogenic regulator, is increasingly being observed to temporally correlate with capillary regression, suggesting that increased TSP-1 (and not reduction in VEGF per se) is needed to initiate, and likely regulate, capillary regression.
Membranous nephropathy: A fairy tale for immunopathologists, nephrologists and patients.
Review
New
Debiec et al., Paris, France. In Mol Immunol, Nov 2015
It shows how experimental models developed more than 30 years ago have led to the identification of several human antigens including neutral endopeptidase in the neonate, phospholipase A2 receptor, and thrombospondin 1 domain 7A in the adult, and cationic bovine serum albumin in children.
Thrombospondin-1 as a Regulator of Corneal Inflammation and Lymphangiogenesis: Effects on Dry Eye Disease and Corneal Graft Immunology.
Review
New
Cursiefen et al., Köln, Germany. In J Ocul Pharmacol Ther, Sep 2015
Thrombospondin-1 (TSP-1) is a matricellular glycoprotein that belongs to a family of evolutionary highly conserved calcium-binding proteins consisting of 5 members (TSP-1-TSP-5).
Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
Impact
Lambeau et al., Antibes, France. In N Engl J Med, 2015
Mass spectrometry identified this antigen as thrombospondin type-1 domain-containing 7A (THSD7A).
Original insights on thrombospondin-1-related antireceptor strategies in cancer.
Review
Dedieu et al., Reims, France. In Front Pharmacol, 2014
Thrombospondin-1 (TSP-1) is a large matricellular glycoprotein known to be overexpressed within tumor stroma in several cancer types.
Thyroid Hormone, Hormone Analogs, and Angiogenesis.
Mousa et al., Albany, United States. In Compr Physiol, 2014
From αvβ3, Nanotetrac also downregulates expression of VEGFA and epidermal growth factor receptor (EGFR) genes, upregulates transcription of the angiogenesis suppressor gene, thrombospondin 1 (THBS1; TSP1) and decreases cellular abundance of Ang-2 protein and matrix metalloproteinase-9.
Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.
Impact
Kim et al., Boston, United States. In Cell, 2014
Gain- and loss-of-function experiments showed that BMP4-Bmpr1a signaling triggers calcineurin/NFATc1-dependent expression of thrombospondin-1 (Tsp1) in lung endothelial cells to drive alveolar lineage-specific BASC differentiation.
Ossifying fibroma tumor stem cells are maintained by epigenetic regulation of a TSP1/TGF-β/SMAD3 autocrine loop.
Impact
Shi et al., Los Angeles, United States. In Cell Stem Cell, 2013
The elevated TGF-β activity is tightly regulated by JHDM1D-mediated epigenetic regulation of thrombospondin-1 (TSP1), forming a JHDM1D/TSP1/TGF-β/SMAD3 autocrine loop.
The perivascular niche regulates breast tumour dormancy.
Impact
Bissell et al., Berkeley, United States. In Nat Cell Biol, 2013
These models demonstrated that endothelial-derived thrombospondin-1 induces sustained BCC quiescence.
Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.
GeneRIF
Bramlett et al., Miami, United States. In Neuroreport, 2012
Found that trauma-induced expression and release of TSP-1 involved purinergic signaling as both expression and release were significantly attenuated by a P2Y receptor antagonist.
Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.
GeneRIF
Raman et al., United States. In Am J Physiol Cell Physiol, 2012
Aortic smooth muscle cell migration and proliferation in response to leptin is significantly inhibited by a TSP-1 blocking antibody, revealing the physiological significance of leptin-TSP-1 crosstalk.
Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activation.
GeneRIF
Murphy-Ullrich et al., Birmingham, United States. In Biochem Biophys Res Commun, 2012
These studies show that TSP1 regulated TGF-beta activity is a critical determinant of osteoblast differentiation.
A thrombospondin-dependent pathway for a protective ER stress response.
Impact
Molkentin et al., Cincinnati, United States. In Cell, 2012
Thrombospondin (Thbs) proteins are induced in sites of tissue damage or active remodeling.
[Expression of thrombospondin-1 in the lung of hypoxic pulmonary hypertension rats].
GeneRIF
Yang et al., Yinchuan, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2012
The expression of TSP-1 appears to be increased in hypoxic pulmonary hypertension rats, which may contribute to the pathogenesis of hypoxic pulmonary vascular remodeling.
Thrombospondin-1 type 1 repeats in a model of inflammatory bowel disease: transcript profile and therapeutic effects.
GeneRIF
Gutierrez et al., Wilkes-Barre, United States. In Plos One, 2011
possible functions and potential therapeutic effects of type 1 repeats domain of thrombospondin-1 in inflammatory bowel disease
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