gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Thyroid peroxidase

thrombopoietin, TPO, thyroid peroxidase
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: HAD, AGE, thyroglobulin, CAN, MPL
Papers using thrombopoietin antibodies
BAFF: a local and systemic target in autoimmune diseases
Supplier
Miyakawa Hiroshi et al., In Clinical and Developmental Immunology, 2008
... Serum anti-TPO antibody, TSH, and free T4 levels were examined prior to therapy and six months after the start of therapy using commercially available ECLIA kits (MBL, Nagoya, Japan and Eiken, ...
Papers on thrombopoietin
Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation.
New
Fukuda et al., Tokyo, Japan. In Biol Blood Marrow Transplant, Feb 2016
Eltrombopag is an oral thrombopoietin receptor agonist whose efficacy against persistent thrombocytopenia after allogeneic HCT has not been well characterized.
Evolving insights into the synergy between erythropoietin and thrombopoietin and the bipotent Erythroid/Megakaryocytic progenitor cell.
Review
New
Kaushansky et al., Seattle, United States. In Exp Hematol, Feb 2016
UNASSIGNED: Although the synergy between erythropoietin and thrombopoietin was previously pointed out , the clonal demonstration of a human bipotent Erythroid/Megakaryocytic progenitor (MEP) was first published in ExpHem (April 1996) and later in the same year by Debili et al in Blood.
Is ITP a thrombophilic disorder?
Review
New
Rodeghiero, Vicenza, Italy. In Am J Hematol, Jan 2016
Stemming from the interest for the safety of thrombopoietin-receptor agonists (TPO-ra) romiplostim and eltrombopag, recent data have investigated if thrombotic risk is also increased in this disorder.
Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions.
New
Segner et al., Bern, Switzerland. In Aquat Toxicol, Jan 2016
Both chemicals significantly altered transcript levels of thyroid system-related genes (TRα, TRβ, TPO, TSH, DIO1, DIO2 and DIO3) in a compound-specific way.
A Homozygous Nonsense Thyroid Peroxidase Mutation (R540X) Consistently Causes Congenital Hypothyroidism in Two Siblings Born to a Consanguineous Family.
New
Üstek et al., İstanbul, Turkey. In J Clin Res Pediatr Endocrinol, Jan 2016
OBJECTIVE: Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder, and mutations in the thyroid peroxidase (TPO) gene have been reported to cause the disease.
Novel functions of platelets in the liver.
Review
New
Ohkohchi et al., Tsukuba, Japan. In J Gastroenterol Hepatol, Jan 2016
Thrombocytopenia, which is frequently observed in patients with chronic liver disease (CLD) and cirrhosis, is due to various causes, such as decreased thrombopoietin production and accelerated platelet destruction caused by hypersplenism; however, the relationship between thrombocytopenia and hepatic pathogenesis and the role of platelets in CLD are poorly understood.
Pendulum swings from hypo- to hyperthyroidism: thyrotoxicosis after severe hypothyroidism following neck irradiation in a patient with a history of Hodgkin's lymphoma.
New
Lewiński et al., Łódź, Poland. In Thyroid Res, Dec 2015
At the age of 20 this was followed by severe hypothyrodism [TSH > 100 μIU/mL (reference range: 0.27-4.2)].
Thrombocytopenia in MDS: epidemiology, mechanisms, clinical consequences and novel therapeutic strategies.
Review
New
Verma et al., United States. In Leukemia, Nov 2015
Dysregulated thrombopoietin (TPO) signaling and increased platelet destruction through immune or nonimmune mechanisms are frequently observed in MDS.
Current Management of Primary Immune Thrombocytopenia.
Review
New
Newland et al., London, United Kingdom. In Adv Ther, Nov 2015
A new class of drugs, the thrombopoietin receptor agonists, has been developed for use in ITP.
Eltrombopag for children with chronic immune thrombocytopenia (PETIT2): a randomised, multicentre, placebo-controlled trial.
New
Impact
Bailey et al., Manchester, United Kingdom. In Lancet, Nov 2015
BACKGROUND: The thrombopoietin receptor agonist eltrombopag has been shown to be safe, tolerable, and effective for adults with chronic immune thrombocytopenia.
Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.
New
Impact
Plo et al., Villejuif, France. In Nat Genet, Oct 2015
Using induced pluripotent stem cells and primary cells, we demonstrate that overexpression of ATG2B and GSKIP enhances hematopoietic progenitor differentiation, including of megakaryocytes, by increasing progenitor sensitivity to thrombopoietin (TPO).
TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells.
New
Impact
Li et al., Shanghai, China. In Cell Stem Cell, Aug 2015
We previously found that colorectal cancer tumor-initiating cells (TICs) expressing CD110, the thrombopoietin (TPO)-binding receptor, mediate liver metastasis.
Use of a novel floxed mouse to characterise the cellular source of plasma coagulation FXIII-A.
New
Impact
Grant et al., Montréal, Canada. In Lancet, Mar 2015
The resultant mice were compared with a Mpl-/- (thrombopoietin receptor knockout) thrombocytopenic murine model.
A Novel Mutation in Thyroid Peroxidase Gene Causing Congenital Goitrous Hypothyroidism in a German-Thai Patient.
New
Trachoo et al., In J Clin Res Pediatr Endocrinol, Feb 2015
We report on a 26-year-old German-Thai male with congenital hypothyroidism caused by a compound heterozygous mutation in the thyroid peroxidase (TPO) gene.
The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.
Impact
Hoffmeister et al., Boston, United States. In Nat Med, 2015
Binding of desialylated platelets to the AMR induces hepatic expression of thrombopoietin (TPO) mRNA and protein, thereby regulating platelet production.
Mutation in the THPO gene is not associated with aplastic anaemia in Japanese children.
GeneRIF
Kojima et al., In Br J Haematol, 2012
Mutation in the THPO gene is not associated with aplastic anaemia in Japanese children.
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
Impact
GeneRIF
de Lange et al., New York City, United States. In Cell, 2012
Study documents the combinatorial action of Apollo, POT1b, CST, and the 5' exonuclease Exo1 in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
Hereditary thrombocythemia caused by a thrombopoietin (THPO) gain-of-function mutation associated with multiple myeloma and congenital limb defects.
GeneRIF
Kulozik et al., Heidelberg, Germany. In Ann Hematol, 2012
Overstimulation of the THPO pathway might therefore predispose to clonal hematopoietic disease and to congenital abnormalities.
Minimally invasive follicular thyroid carcinoma developed in dyshormonogenetic multinodular goiter due to thyroid peroxidase gene mutation.
GeneRIF
Tenenbaum-Rakover et al., Israel. In Thyroid, 2012
analysis of how minimally invasive follicular thyroid carcinoma developed in dyshormonogenetic multinodular goiter due to thyroid peroxidase gene mutation [case report]
Thrombopoietin as biomarker and mediator of cardiovascular damage in critical diseases.
Review
GeneRIF
Montrucchio et al., Torino, Italy. In Mediators Inflamm, 2011
Thrombopoietin is a biomarker and mediator of cardiovascular damage in critical diseases [review]
share on facebooktweetadd +1mail to friends